medigraphic.com
ISSN 1561-3011 (Digital)

2020, Número 1

<< Anterior Siguiente >>

Rev Cubana Invest Bioméd 2020; 39 (1)


Actividad biológica y toxicológica de los ácidos biliares en la actualidad

Piñol JFN, Ruiz TJF, Segura FN, Proaño TPS, Sánchez FEM

Idioma: Español
Referencias bibliográficas: 36
Paginas: 1-14
Archivo PDF: 598.28 Kb.


RESUMEN

Introducción: los ácidos biliares no solo tienen como actividad biológica regular la absorción de vitaminas liposolubles, colesterol y lípidos, sino actúan también como moléculas de señalización, moduladores de la proliferación celular intestinal, de la expresión de genes y del metabolismo energético según estudios in vitro e in vivo; en condiciones fisiológicas mantienen su homeostasis, que al ser interrumpida promueve suacción toxicológica.
Objetivo: describir la actualidad de los nuevos conocimientos sobre la actividad biológica y toxicológica de los ácidos biliares en el aparato digestivo, dirigido a cirujanos generales, gastroenterólogos, clínicos y fisiólogos que les permitan contextualizar el proceso inflamación-carcinogénesis relacionado con los efectos toxicológicos de los ácidos biliares.
Método: se realizó una revisión sistemática de la actividad biológica y toxicológica de los ácidos biliares para los cirujanos generales, gastroenterólogos, clínicos y fisiólogos, como herramienta útil en la compresión fisiopatológico del metabolismo de los ácidos biliares.
Conclusión: los ácidos biliares desempeñan una función clave como moléculas de señalización en la modulación de la proliferación de células epiteliales, la expresión de genes y el metabolismo energético, que cuando se interrumpe su homeostasis se promueve la acción tóxica de estos, lo que se traduce en el proceso inflamación-carcinogénesis digestiva.


REFERENCIAS (EN ESTE ARTÍCULO)

  1. Heaton KW. The importance of keeping bile salts in their place. Gut [Internet]. 1969[Consulted 2018 dec 13];10(10):857-63. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1552987/.

  2. Dawson PA, Lan T, Rao A. Bile acid transporters. J Lipid Res [Internet]. 2009 [Consulted 2018 dec 13]; 50(12):2340-57. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2781307/.

  3. Li T, Chiang JYL. Nuclear receptors in bile acid metabolism. Drug Metab Rev [Internet]. 2013 [Consulted 2018 dec 13]; 45(1):145-55. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3676171/.

  4. Jenkins G, Hardie JL. Bile Acids Toxicology and Bioactivity. Cambridge, UK: The Royal Society of Chemistry; 2008. p. 170. Available from: https://doi.org/10.1039/9781847558336

  5. Di Ciaula A, Garruti G, LunardiBaccetto R, Molina-Molina E, Bonfrate L, Wang DQH, et al. Bile Acid Physiology. Ann Hepatol [Internet].2017[Consulted 2018 dec 13];16:S4-S14.Availablefrom: http://www.sciencedirect.com/science/article/pii/S1665268119310385.

  6. De Aguiar Vallim Thomas Q, Tarling Elizabeth J, Edwards Peter A. Pleiotropic Roles of Bile Acids in Metabolism. Cell Metab [Internet].2013[Consulted 2018 dec 13]; 17(5):657-69. Available from: http://www.sciencedirect.com/science/article/pii/S1550413113001174.

  7. Boyer JL. Bile Formation and Secretion. ComprPhysiol [Internet].2013 Jul [Consulted 2019 jun 10];3(3):1035‐78. Available from: https://doi.org/10.1002/cphy.c120027.

  8. Reshetnyak VI. Physiological and molecular biochemical mechanisms of bile formation. World J Gastroenterol [Internet].2013[Consulted 2018 dec 13];19(42):7341-60. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3831216/.

  9. Hofmann AF, Hagey LR. Key discoveries in bile acid chemistry and biology and their clinical applications: history of the last eight decades. J Lipid Res [Internet]. 2014[Consulted 2018 dec 13];55(8):1553-95. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4109754/

  10. Zhou H, Hylemon PB. Bile acids are nutrient signaling hormones. Steroids [Internet]. 2014 [Consulted 2018 dec 13]; 86:62-8. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4073476/.

  11. Stenman LK, Holma R, Korpela R. High-fat-induced intestinal permeability dysfunction associated with altered fecal bile acids. World J Gastroenterol [Internet].2012[Consulted 2018 dec 13];18(9):923-9. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3297051/.

  12. Ridlon JM, Kang DJ, Hylemon PB, Bajaj JS. Bile acids and the gut microbiome. CurrOpinGastroenterol [Internet].2014[Consulted 2018 dec 13]; 30(3):332-8. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4215539/.

  13. Howles PN. Cholesterol Absorption and Metabolism. 2016[Consulted 2018 dec 13]. In: Mouse Models for Drug Discovery: Methods and Protocols [Internet]. New York, NY: Springer New York; p. 177-97. Available from: https://doi.org/10.1007/978-1-4939-3661-8_11.

  14. Molinaro A, Wahlström A, Marschall H-U. Role of Bile Acids in Metabolic Control. Trends EndocrinolMetab [Internet].2018[Consulted 2018 dec 13];29(1):31-41. Available from: http://www.sciencedirect.com/science/article/pii/S1043276017301510.

  15. Ridlon JM, Bajaj JS. The human gut sterolbiome: bile acid-microbiome endocrine aspects and therapeutics. Acta Pharm Sin B [Internet].2015[Consulted 2018 dec 13];5(2):99-105. Available from: http://www.sciencedirect.com/science/article/pii/S221138351500009X.

  16. Halilbasic E, Claudel T, Trauner M. Bile acid transporters and regulatory nuclear receptors in the liver and beyond. J Hepatol [Internet].2013 [Consulted 2018 dec 13];58(1):155-68. Available from: http://www.sciencedirect.com/science/article/pii/S0168827812006228.

  17. Paniagua M, Pinol F, Cendan A. Effect of microcrystalline cellulose on alkaline gastritis due to bile reflux. ActaGastroenterolLatinoam [Internet].1997[Consulted 2018 dec 13]; 27(2):75-9. Available from: https://www.ncbi.nlm.nih.gov/pubmed/9412131.

  18. Piñol Jiménez F, Paniagua Estévez M, Pérez Sánchez G, GraOramas B, CendánCordoví A, Borbolla Busquets E. Metaplasia intestinal en pacientes con reflujo duodenogástrico y ácidos biliares totales elevados. Rev Cubana Med [Internet]. 2010 [Consulted 2018 dec 13]; 49:17-32. Available from: http://scielo.sld.cu/scielo.php?script=sci_arttext&pid=S0034-75232010000100003&nrm=iso.

  19. Paniagua Estévez ME, Piñol Jiménez FN. Nueva terapéutica en la gastritis alcalina. Santa fe de Bogota, Colombia: Ediciones MTI; 1997.

  20. Mosińska P, Szczepaniak A, Fichna J. Bile acids and FXR in functional gastrointestinal disorders. Digest Liver Dis [Internet].2018 [Consulted 2018 dec 13];50(8):795-803. Available from: http://www.sciencedirect.com/science/article/pii/S1590865818307606.

  21. Schaap FG, Trauner M, Jansen PLM. Bile acid receptors as targets for drug development. Nat Rev GastroenterolHepatol[Internet].2013 [Consulted 2018 dec 13];11:55. Available from: https://doi.org/10.1038/nrgastro.2013.151.

  22. Burris TP, Solt LA, Wang Y, Crumbley C, Banerjee S, Griffett K, et al. Nuclear Receptors and Their Selective Pharmacologic Modulators. Pharmacol Rev [Internet].2013[Consulted 2018 dec 13];65(2):710. Available from: http://pharmrev.aspetjournals.org/content/65/2/710.abstract.

  23. Hofmann AF, Hagey LR. Bile Acids: Chemistry, Pathochemistry, Biology, Pathobiology, and Therapeutics. Cell Mol Life Sci [Internet].2008[Consulted 2018 dec 13];65(16):2461-83. Available from: https://doi.org/10.1007/s00018-008-7568-6.

  24. Ridlon JM, Wolf PG, Gaskins HR. Taurocholic acid metabolism by gut microbes and colon cancer. Gut Microbes [Internet].2016[Consulted 2018 dec 13];7(3):201-15. Available from: https://doi.org/10.1080/19490976.2016.1150414.

  25. Devkota S, Wang Y, Musch MW, Leone V, Fehlner-Peach H, Nadimpalli A, et al. Dietary-fat-induced taurocholic acid promotes pathobiont expansion and colitis in Il10-/- mice. Nature [Internet].2012[Consulted 2018 dec 13]; 487(7405):104-8. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3393783/.

  26. Chen ML, Takeda K, Sundrud MS. Emerging roles of bile acids in mucosal immunity and inflammation. Mucosal Immunol [Internet].2019[Consulted 2018 dec 13];12(4):851-61. Available from: https://doi.org/10.1038/s41385-019-0162-4.

  27. Dermadi D, Valo S, Ollila S, Soliymani R, Sipari N, Pussila M, et al. Western Diet Deregulates Bile Acid Homeostasis, Cell Proliferation, and Tumorigenesis in Colon. Cancer Res [Internet]. 2017 [Consulted 2018 dec 13]; 77(12):3352. Available from: http://cancerres.aacrjournals.org/content/77/12/3352.abstract.

  28. Nguyen TT, Ung TT, Kim NH, Jung YD. Role of bile acids in colon carcinogenesis. World J Clin Cases [Internet]. 2018 [Consulted 2018 dec 13]; 6(13):577-88. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6232560/.

  29. SawkatM A. Intracellular signaling by bile acids [Internet].2012[Consulted 2018 dec 13];20:1-23. Available from: https://dx.doi.org/10.3329/jbs.v20i0.17647.

  30. Zhu C, Fuchs CD, Halilbasic E, Trauner M. Bile acids in regulation of inflammation and immunity: friend or foe?ClinExpRheumatol. [Internet].2016[Consulted 2018 dic 11];34(4Suppl98):25-31. Available from: http://www.clinexprheumatol.org/pubmed/find-pii.asp?pii=27586800.

  31. Roos WP, Kaina B. DNA damage-induced cell death: from specific DNA lesions to the DNA damage response and apoptosis. Cancer lett [Internet].2013[Consulted 2018 dic 21];332(2):237-48. Available from: https://dx.doi.org/10.1016/j.canlet.2012.01.007.

  32. Palmeira CM, Rolo AP. Mitochondrially-mediated toxicity of bile acids. Toxicology [Internet].2004[Consulted 2015 dic 21];203(1-3):1-15. Available from: https://dx.doi.org/10.1016/j.tox.2004.06.001.

  33. Morgan MJ, y Liu ZG. Crosstalkof reactive oxygen species and NF-kapácidosbiliares signaling. Cell Res [Internet].2011[Consulted 2018 dic 21];21(1):103-15. Available from: https://dx.doi.org/10.1038/cr.2010.178.

  34. Lozano G. The Enigma of p53. Cold Spring HarbSymp Quant Biol [Internet].2016[Consulted 2018 dec 13];81:37-40. Available from: http://symposium.cshlp.org/content/81/37.full.pdf+html.

  35. López M, Anzola M, Cuevas-Salazar N, Aguirre JM, Martínez de Pancorbo M. p53, a tumor suppressor gene. Gaceta Med Bilbao [Internet].2001[Consulted 2015 dic 21];98(1):21-7. Available from: http://www.sciencedirect.com/science/article/pii/S0304485801743508.

  36. Mendoza-Rodríguez CA, Cerbón MA. Tumor suppressor gene p53: mechanisms of action in cell proliferation and death. Rev Invest Clin [Internet].2000[Consulted 2015 dic 21];53(3):266-73. Available from: http://europepmc.org/ácidosbiliarystract/med/11496714.




2020     |     www.medigraphic.com