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Colegio de Medicina Interna de México.
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2021, Number 4

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Med Int Mex 2021; 37 (4)

Deep venous thrombosis following treatment with intravenous immunoglobulin

Rodríguez-Quintero JR, Andrade-Castellanos CA
Full text How to cite this article

Language: Spanish
References: 10
Page: 623-626
PDF size: 206.79 Kb.


Key words:

Intravenous immunoglobulins, Thrombosis, Deep vein thrombosis.

ABSTRACT

Background: Thrombosis resulting from intravenous immunoglobulin infusion is an uncommon complication.
Clinical case: A 22-year-old male patient with X-linked agammaglobulinemia who developed deep venous thrombosis soon after intravenous immunoglobulin (IVIG) administration.
Conclusions: We consider the case of interest due to the low frequency of deep vein thrombosis secondary to IVIG treatment in clinical practice, especially in patients with primary immunodeficiencies.


REFERENCES

  1. Goodacre S, Sampson F, Thomas S, van Beek E, et al. Systematic review and meta-analysis of the diagnostic accuracy of ultrasonography for deep vein thrombosis. BMC Med Imaging 2005; 5: 6. doi. 10.1186/1471-2342-5-6.

  2. Espinosa-Rosales FJ, Bergés-García A, Coronado-Zarco IA, Dávila-Gutiérrez G, et al. Consenso Mexicano para la prescripción de inmunoglobulina G como tratamiento de reemplazo e inmunomodulación. Acta Pediatr Mex 2018; 39 (2): 134-171. https://doi.org/10.18233/apm- 39no2pp134-1711574.

  3. FDA Safety Communication. New boxed warning for thrombosis related to human immune globulin products. https://primaryimmune.org/fda-safety-communicationnew- boxed-warning-for-thrombosis-related-to-humanimmune- globulin-products. Accesado el 6 de Septiembre de 2019.

  4. Marie I, Maurey G, Hervé F, Hellot MF, et al. Intravenous immunoglobulin-associated arterial and venous thrombosis; report of a series and review of the literature. Br J Dermatol 2006; 155 (4): 714-721. doi. 10.1111/j.1365- 2133.2006.07390.x.

  5. Flannery MT, Humphrey D. Deep venous thrombosis with pulmonary embolism related to IVIg treatment: A case report and literature review. Case Rep Med 2015; 2015: 971321. doi. 10.1155/2015/971321.

  6. Paran D, Herishanu Y, Elkayam O, Shopin L, et al. Venous and arterial thrombosis following administration of intravenous immunoglobulins. Blood Coagul Fibrinolysis 2005; 16 (5): 313-318. doi. 10.1097/01.mbc.0000172694.85233.a8.

  7. Woodruff RK, Grigg AP, Firkin FC, Smith IL. Fatal thrombotic events during treatment of autoimmune thrombocytopenia with intravenous immunoglobulin in elderly patients. Lancet 1986; 2 (8500): 217-218. doi. 10.1016/s0140- 6736(86)92511-0.

  8. Zaidan R, Al Moallem M, Wani BA, Shameena AR, et al. Thrombosis complicating high dose intravenous immunoglobulin: report of three cases and review of the literature. Eur J Neurol 2003; 10 (4): 367-372. doi. 10.1046/j.1468- 1331.2003.00542.x.

  9. Ammann EM, Haskins CB, Fillman KM, Ritter RL, et al. Intravenous immune globulin and thromboembolic adverse events: A systematic review and meta-analysis of RCTs. Am J Hematol 2016; 91 (6): 594-605. doi. 10.1002/ajh.24358.

  10. Stiehm ER. Adverse effects of human immunoglobulin therapy. Transfus Med Rev 2013; 27 (3): 171-178. doi. 10.1016/j.tmrv.2013.05.004.




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Med Int Mex. 2021;37