2021, Number 1
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Rev Mex Patol Clin Med Lab 2021; 68 (1)
Variations in plasma and salivary glucose concentration in healthy subjects
Flores MCE, Ramírez AD, Valdez CP, Gallardo JM
Language: Spanish
References: 42
Page: 11-17
PDF size: 246.81 Kb.
ABSTRACT
Introduction: Saliva is a fluid composed of several elements including glucose and it is possible that it can be used to detect changes in this and other analytes, its use as a means of diagnosis has an increasing trend.
Objective: The purpose of this study was to compare the concentrations of proteins, glucose, and glycosylation end products (AGEs) in saliva and plasma in apparently healthy young men and women.
Material and methods: Unstimulated saliva and plasma samples were obtained from 91 subjects (46 women and 45 men) in apparent good health and after an 8-hour fast. The concentrations of proteins, glucose, and AGEs in saliva and plasma were measured by standardized procedures.
Results: We found that the unstimulated salivary flow velocity was different between both sexes (p = 0.078). There are no differences between proteins (p = 0.3173), glucose (p = 0.6636) or AGEs (p = 0.1082). Regarding plasma values, there are no differences between the sexes of the following: proteins (p = 0.4718), glucose (p = 0.3404) or HbA1c (p = 0.6871), however there is a difference in AGEs (p = 0.0162) which was higher in women. Regarding the differences between saliva and plasma, we found that the proteins are 100 times lower, the glucose concentration was 5.6 times lower, both in women and in men, and the AGEs concentration was 5.6 times lower in the saliva for women and 6.7 times less in saliva for men.
Conclusions: The results suggested that the concentrations of related analytes in glucose metabolism in saliva might be a good method to non-invasively assess both the diagnosis and the progression of carbohydrate metabolic disorders.
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