Pérez CAE, Contreras SM, Valverde GYA, Hernández PF, Anides FAE, Lemini LA

Language: Spanish
References: 11
Page: 234-240
PDF size: 477.78 Kb.

ABSTRACT

Background: graft-versus-host disease (GVHD) is a complication in hematopoietic stem cell transplant. Clinical manifestations are varied so histopathology plays a main role.
Objective: to determine correlation between the clinical and histopathological classification of patients with acute and chronic cutaneous GVHD, at the Hospital de Especialidades del Centro Médico Nacional Siglo XXI, IMSS, from March 2016 to December 2019.
Material and methods: an observational, retrospective, analytical cohort-type study of 62 patients with suspected acute or chronic cutaneous gvhd was carried out. Routine skin biopsy sections were reviewed to establish the clinical-pathological correlation.
Results: the correlation coefficient (Spearman’s Rho) between the clinical classification and the histopathological study in acute GVHD was 0.549 (moderate), and for chronic GVHD it was 0.575 (moderate).
Conclusions: a lack of correlation between clinical and histological grade has been reported in cutaneous GVHD. Although there are histopathological criteria for the diagnosis of GVHD, their interpretation may vary between observers. The clinical and histopathological correlation in cutaneous GVHD in our study was moderate, as has been described in other studies.

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