González HM, Bastidas RBE, Ruiz MB, Godínez S, Panduro A

Language: Spanish
References: 10
Page: 140-146
PDF size: 90.04 Kb.

ABSTRACT

Adipose tissue is the largest energy reservoir in the organism. Adipocytes contain all the enzymes required for the processes of lipogenesis and lipolysis, both metabolic processes modulated by hormones, cytokines and other molecules involved in the fine regulation of energy metabolism. White adipocytes are very active in the synthesis and secretion of endocrine, paracrine and autocrine signals that act locally. Some of these signals are believed to be implicated in the metabolism of adipose tissue and several of them also participate in the network of signals involved in the regulation of functions in different cell types located in distant organs, such as hypothalamus, liver, pancreas, skeletal muscle, etc. Adipocytes function as endocrine secretory cells. Recently, extensive evidence supports the fact that several cytokines, hormones, growth factors and other polypeptides are expressed and secreted in human adipose tissue. In this review we present those factors that have already been identified as products of the adipose tissue and some of their known functions, especially those that are considered to play a role in the pathophysiology of insulin resistance, obesity and diabetes mellitus type 2.

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