Sanjurjo GJL, Pérez MJ, Hidalgo LH, Geyne A

Language: Spanish
References: 7
Page: 172-175
PDF size: 43.03 Kb.

ABSTRACT

The efficacy and safety of nitazoxanide + bismuth subcitrate (SCBi) + lansoprazole, in the treatment of 90 episodes of dyspepsia, ulcerative and non ulcerative due to Helicobacter pylori infection, were studied. Patients were treated orally with nitazoxanide 1,000 mg + SCBi 240 mg + lansoprazole 30 mg BID during 7 days (Group 1, n = 29); nitazoxanide 500 mg + SCBi 120 mg + lanzoprazole 30 mg BID during 14 days, (Group II, n = 28); and nitazoxanide 1000 mg + SCBi 240 mg + lansoprazole 30 mg BID during 14 days (Group III, n = 29). The diagnosis of patients at the start of the therapy was done by endoscopy, and CLO test, for identification of H. pylori. In 12 of the 29 patients of the Group I, H. pylori was eradicated (41.37%), in the remaining 17 there were clinical improvement. In the Group II, 21 of the 28 patients (75%) had H. pylori eradication, 7 patients showed clinical improvement. In 25 of the 29 patients (83%) H. pylori was eradicated and clinical improvement was assessment in 5. The most common diagnosis was gastritis (86% of H. pylori eradication) follow by duodenitis 83% of H. pylori eradication and peptic ulcer (100% of H. pylori eradication in duodenal ulcer in the group 2). There were not serious adverse effects. The most common were nausea, headache, yellow color of the urine and epigastric pain. Those results support the usefulness, efficacy and safety of nitazoxanide + bismuth subcitrate + lansoprazole, in the treatment of Helicobacter pylori infection.

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