Suárez-Cuenca JA, Toledo-Lozano CG, Alcaraz-Estrada SL, Mondragón-Terán P, Montiel-López L, De la Vega-Bravo AH, García S

Language: Spanish
References: 0
Page: 67-74
PDF size: 204.14 Kb.

ABSTRACT

Objective: To explored whether initial laboratory data and symptoms predict further clinical outcome.
Materials and Methods: Retrospective cohort study. Clinical records from March to September 2020 were revised to extract clinical-demographic characteristics, laboratory data and outcomes from patients with SARS-CoV-2 pneumonia, admitted to Centro Médico Nacional 20 de Noviembre, ISSSTE, Mexico City.
Results: One thousand three patients were evaluated at the Emergency-Triage, diagnosed with SARS-CoV-2 and received further in-hospital medical attention. Most of the patients were younger than 65 years-old, male and showed co-morbid conditions, such as obesity, hypertension or diabetes mellitus. After standard therapy, 389 cases (39%) required mechanical ventilation, vasopressor agents or showed fatal outcome. Higher values of C-reactive protein, D-dimer, procalcitonin and low O₂2 saturation at triage significantly predicted mechanical ventilation (p ‹ 0.05) and mortality (p ‹ 0.05); while presenting symptoms like fever, myalgia, cough and ageusia showed a particular association with longer hospital stage (p ‹ 0.05).
Conclusions: Laboratory values and presenting symptoms, both evaluated at hospital admission, showed different ability to predict clinical severity, mortality and longer hospitalization time in patients with COVID-19 pneumonia. These results could be useful in possible future pandemic waves of SARS-CoV-2.