Alcántara-Ramírez VD, Gutiérrez-Ayala D, Gutiérrez-Ávila SA, López-Carrillo MY, Arenas R

Language: Spanish
References: 13
Page: 53-57
PDF size: 406.72 Kb.

ABSTRACT

According to the World Health Organization (WHO), in the classification of cutaneous lymphomas, T/NK cell lymphoma is divided into two categories: extranodal T/NK nasal type (Lenktn), and aggressive NK cell leukemia. As such, the extranasal type includes the skin, gastrointestinal system, spleen, testes, salivary glands, lungs, and bone marrow. Although the etiology is unknown, most of the time an association with the Epstein-Barr virus has been seen. These lymphomas generally present in an advanced stage at diagnosis, with multisystemic involvement, so the most important prognostic factor is the extension of the disease at the time of diagnosis and the early establishment of appropriate treatment. We present the case of a 65-yearold patient with extranasal T-cytotoxic phenotype T/NK cell lymphoma who developed mainly cutaneous manifestations, received chemotherapy with good initial response, however, due to the associated infectious complications, it had a fatal outcome.

REFERENCES

1. Young LS y Rickinson AB, Epstein-Barr virus: 40 years on, Nat Rev Cancer 2004; 4:757-68.

2. Wilcox RA, Cutaneous t-cell lymphoma: 2017 update on diagnosis, risk-stratification, and management, Am J Hematol 2017; 92(10):1085- 102.

3. Van Santen S, Roach RE, Van Doorn R, Horváth B, Bruijn MS, Sanders CJ, De Pooter JC, Van Rossum MM, De Haas ER, Veraart JC, Bekkenk MW, Vermeer MH y Willemze R, Clinical staging and prognostic factors in folliculotropic mycosis fungoides, jama Dermatol 2016; 152(9):992-1000.

4. Swerdlow SH, Campo E, Pileri SA, et al., The 2016 revision of the World Health Organization (who) classification of lymphoid neoplasms, Blood 2016; 127:2375-90.

5. Hamada T, Nakamura S, Young-Hyeh K, Yoshino T et al., Epstein-Barr virus-associated t/natural killer-cell lymphomas in the elderly: the first consensus meeting in Kofu 2013, J Dermatol 2014; 41(1):40-42.

6. Juárez Navarrete L y Rincón-Pérez C. Linfomas cutáneos: fisiopatología y clasificación (primera parte), Dermatol Rev Mex 2005; 49:109-22.

7. Kimura H, Ito Y, Kawabe S, Gotoh K, Takahashi Y, Kojima S et al., ebv-associated t/nk-cell lymphoproliferative diseases in nonimmunocompromised hosts: prospective analysis of 108 cases, Blood 2012; 119:673-86.

8. Rodríguez-Pinilla SM, Barrionuevo C, García J, Martínez MT, Pajares R, Montes-Moreno S et al., ebv-associated cutaneous nk/t-cell lymphoma: review of a series of 14 cases from Peru in children and young adults, Am J Surg Pathol 2010; 34:1773-82.

9. Barrionuevo C, Zaharia M, Martínez MT et al., Extranodal nk/t-cell lymphoma, nasal type: study of clinic pathologic and prognosis factors in a series of 78 cases from Peru, Applimmunohistochem Mol Morphol 2007; 15(1):38-44.

10. Lan MX, Zhen ZX y Ming WH, cd56-negative extranodal nasal type of natural killer/t-cell lymphoma with extranasal skin involvement, Leuk Lymphoma 2009; 50(10):1715-7.

11. Herrera Ariza JL y Villamor Rojas P, Linfoma de células t/natural killer extranodal, tipo nasal extranodal natural killer/t-cell lymphoma, nasal type, Acta Otorrinolaringol Cir Cabeza Cuello 2015; 43(3):216-21.

12. Moreno MS, Pierzchalski JL, Ivanov ML, Verea MA y Torchiari F, Linfoma extraganglionar de células t/nk: presentación de un caso clínico y revisión de la literatura, Arch Argent Dermatol 2014; 64:57-60.

13. Varshney AN, Patidar R, Malhotra M, Behera M, Nagar M y Kataria SP, Extranodal nk/t-cell lymphoma of the nasal type with predominant t-cell markers: a rare subtype of rare disease entity, Int J Med Public Health 2015; 5(4):378-80.