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2021, Number 1

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Revista Cubana de Cirugía 2021; 60 (1)

Characterization of patients with stromal gastrointestinal tumors in ''Arnaldo Milián Castro'' clinical-surgical Hospital

Artiles CMA, Portal BLN, Duarte LY, de la Cruz FDA
Full text How to cite this article

Language: Spanish
References: 22
Page: 1-17
PDF size: 587.79 Kb.


Key words:

gastrointestinal stromal tumors, gastrointestinal neoplasms, sarcoma.

ABSTRACT

Introduction: Gastrointestinal stromal tumor is the most frequent mesenchymal neoplasm in the digestive tract, its diagnosis and treatment is still controversial because it is infrequent.
Objective: To characterize the patients with gastrointestinal stromal tumors treated in our service.
Methods: A longitudinal descriptive observational study was carried out in patients with gastrointestinal stromal tumors treated in the surgery service of the “Arnaldo Milián Castro” Clinical-Surgical Hospital from 2015 to 2018. The sample consisted of 17 patients.
Results: Female patients between 60 and 69 years old (35.3%) predominated (58.82%). Abdominal pain as the most frequent symptom (58.82%). Tumors (47.1%) measured more than 10 cm, spindle cell cellularity (58.8%), mitotic index less than 5 (70.6%), and no infiltrative growth pattern (70.6%). Metastasis absent in (82.4%). Present with equal frequency in the stomach and small intestine (N = 8), the presence of low and high aggressive behavior (35.3%) was the same. The markers CD.117 (41.2%) and CD.34 (35.3%) predominated. Segmental recession of the small intestine with end-to-end anastomosis was the most widely used surgical technique (35.3%).
Conclusions: Despite being mostly large and found in high portions of the digestive tract, many presented a low mitotic index, however, a considerable group presented aggressive behavior. Although it is true that almost all the patients were discharged alive, there is a lack of follow-up at the center, which would be interesting to evaluate in future studies.


REFERENCES

  1. Ferrer Robaina H, Rodríguez Cruz Y, Mesa Izquierdo O, Zayas Díaz L, Blanco Amaro E. Tumor de estroma gastrointestinal en intestino delgado. Revista Cubana de Cirugía. 2017 [acceso 20/01/2020];56:88-94. Disponible en: http://scielo.sld.cu/pdf/cir/v56n2/cir09217.pdf

  2. Estepa Pérez J, Santana Pedraza T, Llamas Fuentes M, Estepa Ramos J. Tumor de estroma gastrointestinal de intestino delgado. Presentación de un caso y revisión de la literatura. MediSur. 2017 [acceso 20/01/2020];15(6):878-83. Disponible en: https://www.redalyc.org/service/redalyc/downloadPdf/1800/180054696017/6

  3. Joensuu H, Rutkowski P, Nishida T, Steigen SE, Brabec P, Plank L, et al. KIT and PDGFRA mutations and the risk of GI stromal tumor recurrence. Journal of Clinical Oncology. 2015 [acceso 20/02/2020];33(6):634-42. Disponible en: https://www.researchgate.net/profile/Piotr_Rutkowski/publication/271334742_KIT_and_PDGFRA_mutations_and_the_risk_of_GI_stromal_tumor_recurrence/links/54f0dcd90cf24eb879416193.pdf

  4. Wood DE. National Comprehensive Cancer Network (NCCN) clinical practice guidelines for lung cancer screening. Thoracic surgery clinics. 2015 [acceso 20/02/2020];25(2):185-97. Disponible en: https://www.nccn.org/professionals/physician_gls/PDF/sarcoma.pdf

  5. Guerra Mesa JL, Lamadrid García J, Ruíz Calderón I. Adenocarcinoma gástrico y tumor estromal del estómago sincrónico incidental. Revista Cubana de Cirugía. 2017 [acceso 20/02/2020];56(4):1-11. Disponible en: http://scielo.sld.cu/scielo.php?script=sci_arttext&pid=S0034-74932017000400011&lng=es

  6. Pasarin MA, Cervet MR, Lerda F, Lopez Vinuesa F. GIST de intestino delgado. Rev argent cir. 2017 [acceso 20/02/2020];109(1):1-10. Disponible en: http://www.scielo.org.ar/pdf/racir/v109n1/v109n1a05.pdf

  7. Navarini D, Albuquerque AB, Rovani ALB, Rohden TB, Reffatti D, de Oliveira AEL, et al. Treatment of posterior gastric wall gastrointestinal stromal tumor with gastric sleeve: A case report. Clinical & Biomedical Research. 2018 [acceso 20/01/2020];38(3):297-300. Disponible en: https://www.seer.ufrgs.br/hcpa/article/download/80239/pdf

  8. Peralta AM, Valenzuela LOM, Espinoza GC, Ruíz VGG, García CGR, Farak TCL, et al. Tumor de GIST pediátrico. Presentación de dos casos y revisión de la literatura. Bol Clin Hosp Infant Edo Son. 2017 [acceso 20/01/2020];34(2):127-35. Disponible en: http://www.medigraphic.com/pdfs/bolclinhosinfson/bis-2017/bis172h.pdf

  9. Ogata K, Kimura A, Nakazawa N, Suzuki M, Yanoma T, Ubukata Y, et al. Long-Term Imatinib Treatment for Patients with Unresectable or Recurrent Gastrointestinal Stromal Tumors. Digestion [Internet]. 2018 [citado 20 ene 2020]; 97(1): [20-5]. Disponible en: https://www.karger.com/Article/Pdf/484102

  10. Tumores del estroma gastrointestinal: guías de práctica clínica ESMO-2018 para diagnóstico, tratamiento y seguimiento. Sociedad Europea de Oncología Médica (ESMO). 2018 [acceso 20/01/2020]. Disponible en: https://colectivogist.files.wordpress.com/2018/06/guiaesmo_gist_2018_castellano.pdf

  11. Bauer S, Rutkowski P, Hohenberger P, Miceli R, Fumagalli E, Siedlecki J, et al. Long-term follow-up of patients with GIST undergoing metastasectomy in the era of imatinib-analysis of prognostic factors (EORTC-STBSG collaborative study). European Journal of Surgical Oncology (EJSO). 2014 [acceso 20/01/2020];40(4):412-9. Disponible en: https://www.sciencedirect.com/science/article/pii/S0748798314000031

  12. Ben-Ami E, Barysauskas CM, von Mehren M. Long-term follow-up results of the multicenter phase II trial of regorafenib in patients with metastatic and/or unresectable GI stromal tumor after failure of standard tyrosine kinase inhibitor therapy. Ann Oncol. 2016 [acceso 20/01/2020];27:1794-99. Disponible en: https://www.sciencedirect.com/science/article/pii/S092375341935865X

  13. Wilches RO, Castañeda ADB, Navia HF, Pedraza RS. Tumor del estroma gastrointestinal (TEGI): terapia adyuvante ¿Cuánto tiempo? Revista Colombiana de Gastroenterología. 2016 [acceso 20/01/2020];31(4):424-32. Disponible en: https://www.revistagastrocol.com/index.php/rcg/article/view/118

  14. Pérez-Calvo J, Castellví-Valls J, Viso-Pons L, Zárate LO-d, González-Santin V, Petrone P, et al. Tratamiento neoadyuvante con imatinib de un tumor gigante del estroma gastrointestinal rectal. Revista Colombiana de Cirugía. 2018 [acceso 20/01/2020];33(4):428- 32. Disponible en: http://www.scielo.org.co/scielo.php?script=sci_arttext&pid=S2011-75822018000400428&lng=en

  15. Medina-Medina JA, Nava-Gutiérrez W, Barrón-Reyes JE, Miranda-Hernández A, Valdes JCL. Incidencia de los tumores del estroma gastrointestinal en la población mexicana. Revisión sistemática. Gaceta Mexicana de Oncología. 2018 [acceso 22/01/2020];17:40-7. Disponible en: https://biblat.unam.mx/hevila/Gacetamexicanadeoncologia/2018/vol17/no1/5.pdf

  16. Estepa-Pérez J, Santana-Pedraza T, Llamas-Fuentes M, Estepa-Ramos J. Tumor de estroma gastrointestinal de intestino delgado. Presentación de un caso y revisión de la literatura. Medisur. 2017 [acceso 24/01/2020];15(6):[aprox. 5 p.]. Disponible en: http://www.medisur.sld.cu/index.php/medisur/article/view/3777

  17. Søreide K, Sandvik OM, Søreide JA, Giljaca V, Jureckova A, Bulusu VR, et al. Global epidemiology of gastrointestinal stromal tumours (GIST): a systematic review of population-based cohort studies. Cancer epidemiology. 2016 [acceso 24/01/2020];40:39-46. Disponible en: https://scholar.google.es/scholar?hl=es&as_sdt=0%2C5&q=Soreide+K%2C+Sandvik+O%2C+S%C3%B8reide+J%2C+Giljaca+V%2CJureckova+A%2C+Bulusu+V.+Global+epidemiology+of+gastrointestinal+stromal+tumours+%28GIST%29%3A+A+systematic+review+of+population-based+cohort+studies.+CancerEpidemiology&btnG=

  18. Acosta Hernández Y, Lantigua Hernández O, Escaig Olivares RL, Vega Somonte MV. Tumor del estroma gastrointestinal de localización gástrica. Presentación de un caso. Rev Méd Electrón. 2017 [acceso 24/01/2020];39(1):S781-90. Disponible en: http://www.revmedicaelectronica.sld.cu/index.php/rme/article/view/1747/3529

  19. Poveda A, Martinez V, Serrano C, Sevilla I, Lecumberri M, De Beveridge R, et al. SEOM Clinical Guideline for gastrointestinal sarcomas (GIST). Clinical and Translational Oncology. 2016 [acceso 24/01/2020];18(12):1221-8. Disponible en: https://link.springer.com/content/pdf/10.1007/s12094-016-1579-9.pdf

  20. Mate PM, López JT, Domínguez JD. Nota científica: tumor del estroma gastrointestinal (GIST) de intestino delgado complicado como causa de abdomen agudo. Revista Asociación de Cirujanos de Castilla y León. 2018 [acceso 24/01/2020];5(1):81-93. Disponible en: http://www.acircal.net/revista/files/12/07_Nota2_GIST_ID_HULP.pdf

  21. D de Wit D, van Erp NP, Khosravan R, Wiltshire R, Allred R, Demetri GD, et al. Effect of gastrointestinal resection on sunitinib exposure in patients with GIST. BMC cancer. 2014 [acceso 23/01/2020];14(1):575. Disponible en: https://link.springer.com/article/10.1186/1471-2407-14-575

  22. García B, Ibarra J, Sola A, Diumenjo M, Binia S, Fader E, et al. Tumores del estroma gastrointestinal: Análisis de 40 casos. Medicina (B. Aires). 2017 [acceso 24/01/2020];77(5):370-2. Disponible en: http://www.scielo.org.ar/scielo.php?script=sci_arttext&pid=S0025-76802017000500004&lng=es




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Revista Cubana de Cirugía. 2021;60