medigraphic.com
Federación Mexicana de Ginecología y Obstetricia, A.C.

2022, Number 05

<< Back Next >>

Ginecol Obstet Mex 2022; 90 (05)

Perception of menstrual cycle changes following SARS-CoV-2 vaccination

Martínez-Schulte A, Sánchez-Aranda A, Olavarría-Guadarrama MY, González CSA, Trujillo-Rangel WÁ, Kably-Ambe A

Language: Spanish
References: 15
Page: 407-416
PDF size: 230.93 Kb.


ABSTRACT

Objective: Identify whether vaccination against COVID-19 is associated with changes in menstrual pattern.
Materiales and Methods: An anonymous observational, cross-sectional to be held from October 4 to 29, 2021 was conducted in a group of women who completed a questionnaire designed to inquire about changes in the menstrual cycle following vaccination. The survey was administered over a four-week period. SPSS software was used for statistical analysis. Changes before and after the application of the first and second doses of COVID-19 vaccine were evaluated with a paired samples t-test and 2.
Results: 4501 patients were collected of whom 1815 were excluded because they did not meet the inclusion criteria; in the end 2686 remained for analysis. Of these, 37.9% (n = 1018) had changes in the menstrual cycle following COVID-19 vaccination; in 61.8% (n = 630) it was in the amount of bleeding. Of the women who reported menstrual cycle changes, 64.34% (n = 655) were after application of messenger RNA vaccines (35.06%; p = 0.19, 95%CI: -0.35-0.19). In relation to the number of doses applied 72.10% (n = 734) reported modifications in the menstrual cycle after l second vaccine (p = 0.01, CI95%: 0.58-0.98).
Conclusions: Vaccination against COVID-19 is associated with small changes in the menstrual cycle, without statistical significance. Women receiving two doses of vaccine had changes in the amount of bleeding.


REFERENCES

  1. Li K, Chen G, Hou H, Liao Q, Chen J, Bai H, et al. Analysis of sex hormones and menstruation in COVID-19 women of child-bearing age. Reprod Biomed Online 2021; 42 (1): 260-7. http://dx.doi.org/10.1016/j.rbmo.2020.09.020

  2. Rabin RC. Los ciclos menstruales pueden haber cambiado tras la vacunación, según un estudio. nytimes. 7 de enero de 2022. https://www.nytimes.com/es/2022/01/07/espanol/ vacunas-covid-menstruacion.html

  3. Xiong J, Lipsitz O, Nasri F, Lui LMW, Gill H, Phan L, et al. Impact of COVID-19 pandemic on mental health in the general population: A systematic review. J Affect Disord 2020; 277: 55-64. https://www.sciencedirect.com/science/ article/pii/S0165032720325891

  4. Ansong E, Arhin SK, Cai Y, Xu X, Wu X. Menstrual characteristics, disorders and associated risk factors among female international students in Zhejiang Province, China: a cross-sectional survey. BMC Womens Health 2019 Feb; 19 (1): 35. http://dx.doi.org/10.1186/s12905-019-0730-5

  5. Sharp GC, Fraser A, Sawyer G, Kountourides G, Easey KE, Ford G, et al. The COVID-19 pandemic and the menstrual cycle: research gaps and opportunities. Int J Epidemiol 2021; http://dx.doi.org/10.1093/ije/dyab239

  6. Edelman A, Boniface ER, Benhar E, Han L, Matteson KA, Favaro C, et al. Association Between Menstrual Cycle Length and Coronavirus Disease 2019 (COVID-19) Vaccination: A US Cohort. Obstet Gynecol 2022. http://dx.doi. org/10.1097/AOG.0000000000004695

  7. CDC. Selected adverse events reported after COVID-19 vaccination . Centers for Disease Control and Prevention 2022. https://www.cdc.gov/coronavirus/2019-ncov/vaccines/ safety/adverse-events.html

  8. WHO. WHO Coronavirus disease (COVID-19) dashboard . https://covid19.who.int/. Bangladesh Physiotherapy Association (BPA); 2020. https://covid19.who.int/

  9. Ndwandwe D, Wiysonge CS. COVID-19 vaccines. Curr Opin Immunol 2021; 71: 111-6. http://dx.doi.org/10.1016/j. coi.2021.07.003

  10. MHRA. Coronavirus vaccine - weekly summary of Yellow Card reporting . https://www.gov.uk/government/publications/ coronavirus-covid-19-vaccine-adverse-reactions/coronavirus- vaccine-summary-of-yellow-card-reporting#annex- 1-vaccine-analysis-print 2022. https://www.gov.uk/ government/publications/coronavirus-covid-19-vaccineadverse- reactions/coronavirus-vaccine-summary-of-yellowcard- reporting#annex-1-vaccine-analysis-print.

  11. NIH. Notice of Special Interest (NOSI) to Encourage Administrative Supplement Applications to Investigate COVID-19 Vaccination and Menstruation (Admin Supp – Clinical Trial Optional). https://grants.nih.gov/grants/guide/noticefiles/ NOT-HD-21-035.html. 2021

  12. Munro MG, Critchley HOD, Fraser IS, FIGO Menstrual Disorders Committee. The two FIGO systems for normal and abnormal uterine bleeding symptoms and classification of causes of abnormal uterine bleeding in the reproductive years: 2018 revisions. Int J Gynaecol Obstet 2018; 143 (3): 393- 408. https://onlinelibrary.wiley.com/doi/10.1002/ijgo.12666

  13. Prado RCR, Silveira R, Asano RY. SARS-CoV-2 (COVID-19) pandemic and a possible impact in the future of menstrual cycle research. Health Sci Rep 2021; 4 (2): e276. http:// dx.doi.org/10.1002/hsr2.276

  14. Girardi G, Bremer AA. Scientific Evidence Supporting Coronavirus Disease 2019 (COVID-19) Vaccine efficacy and safety in people planning to conceive or who are pregnant or lactating. Obstet Gynecol 2022; 139 (1): 3-8. http:// dx.doi.org/10.1097/AOG.0000000000004636

  15. Male V. Menstrual changes after covid-19 vaccination. BMJ 2021; 374: n2211. http://dx.doi.org/10.1136/bmj. n2211




2020     |     www.medigraphic.com