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ISSN 1659-1046 (Print)
Odovtos - International Journal of Dental Sciences

2022, Number 2

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Odovtos-Int J Dent Sc 2022; 24 (2)

Oral Manifestations of Histiocytosis of Langerhans Cells: a Pediatric Case Involving Mandible Bone

Montero-Sánchez RA, Velázquez-Martínez JA, Lecourtois-Amézquita MG

Language: Spanish
References: 23
Page: 212-220
PDF size: 649.18 Kb.


ABSTRACT

Langerhans cells histiocytosis is a rare disease characterized by monoclonal proliferation and migration of special dendritic cells in a variety of organs, most commonly appears eosinophilic granuloma localized, often solitary, and bone lesions that occurs predominantly in pediatric patients. Although is most prevalent in children under the age of 15, this disorder presents in all ages and occurs at a rate of 2 to 5 cases per million per year. LCH is a complex entity; the clinic manifestations can mimic other common conditions and therefore a comprehensive evaluation is indicated. Since oral manifestations are frequent, the early diagnose of this pathology could be detected by dental professionals. The aim of this case report is to describe a case of LCH who initially was misdiagnosed and treated for a dental infection. This disease requires accurate histopathological diagnosis and timely treatment; hence it is necessary to raise awareness among dentists to avoid misdiagnose of oral manifestations of LCH.


REFERENCES

  1. Margo C.E., Goldman D.R. Langerhanscell histiocytosis. Surv Ophthalmol.

  2. 2008; 53: 332-58. doi:10.1016/j.survophthal.2008.04.0072. Satter E.K., High W.A. Langerhans cellhistiocytosis: a review of the current recommendationsof the Histiocyte Society. PediatrDermatol. 2008; 25: 291-5. doi:10.1111/j.1525-1470.2008.00669.x

  3. Allen C.E., Merad M., McClain K.L.Langerhans-cell histiocytosis. N Eng JMed. 2018, 379 (9), 856-868. doi: 10.1056/NEJMra1607548

  4. Krooks J., Minkov M., Weatherall A.G.Langerhans cell histiocytosis in children:History, classification, pathobiology, clinicalmanifestations, and prognosis. J Am AcadDermatol. 2018 Jun; 78 (6): 1035-1044. doi:10.1016/j.jaad.2017.05.059. PMID: 29754885

  5. Guyot-Goubin A., Donadieu J., Barkaoui M.,Bellec S., Thomas C., Clavel J. Descriptiveepidemiology of childhood Langerhans cellhistiocytosis in France, 2000-2004. PediatrBlood Cancer 2008; 51: 71-5. doi:10.1002/pbc.21498

  6. Stålemark H., Laurencikas E., Karis J.,Gavhed D., Fadeel B., Henter J-I. Incidenceof Langerhans cell histiocytosis in children: apopulation-based study. Pediatr Blood Cancer.2008; 51: 76-81. doi:10.1002/pbc.21504

  7. Peckham-Gregory E.C., McClain K.L.,Allen C.E., Scheurer M.E., Lupo P.J. Therole of parental and perinatal characteristicson Langerhans cell histiocytosis: characterizingincreased risk among Hispanics. AnnEpidemiol. 2018; 28: 521-8. https://doi.org/10.1016/j.annepidem.2018.04.005

  8. Venkatramani R., Rosenberg S., IndramohanG., Jeng M., Jubran R. An exploratoryepidemiological study of Langerhans cellhistiocytosis. Pediatr Blood Cancer 2012; 59:1324-6. doi:10.1002/pbc.24136

  9. Haupt R., Minkov M., Astigarraga I., SchäferE., Nanduri V., Jubran R., et al. Langerhanscell histiocytosis (LCH): guidelines fordiagnosis, clinical work-up, and treatment forpatients till the age of 18 years. Pediatr BloodCancer. 2013; 60: 175-184. doi:10.1002/pbc.24367

  10. Su M., Gao Y-J, Pan C., Chen J., Tang J-Y.Outcome of children with Langerhans cellhistiocytosis and single-system involvement:A retrospective study at a single center inShanghai, China. Pediatr Hematol Oncol.2018; 35: 385-92. doi:10.1080/08880018.2018.1545814

  11. Eden P., Abeyasinghe, Mufeesc M.B.M.,Jayasooriya P.R. A series of 13 new casesof langerhans cell histiocytosis of the oralcavity: a master of disguise. Oral Health Care2. 2017. DOI: 10.15761/OHC.1000110

  12. Li Z., Yanqiu L., Yan W., Xiaoying Q.,Hamze F., Siyuan C., et al. Two case reportstudies of Langerhans cell histiocytosis withan analysis of 918 patients of Langerhanscell histiocytosis in literatures published inChina. Int J Dermatol. 2010; 49: 1169-1174.doi:10.1111/j.1365-4632.2009.04360.x

  13. Varga E., Korom I., Polyánka H., SzabóK., Széll M., Baltás E., et al. BRAFV600Emutation in cutaneous lesions of patientswith adult Langerhans cell histiocytosis.J Eur Acad Dermatol Venereol. 2015;29:1205-1211. doi:10.1111/jdv.12792

  14. Rigaud C., Barkaoui M.A., Thomas C.,Bertrand Y., Lambilliotte A., Miron J., et al.Langerhans cell histiocytosis: therapeuticstrategy and outcome in a 30-year nationwidecohort of 1478 patients under 18 years ofage. Br J Haematol. 2016; 174 (6): 887-898.doi:10.1111/bjh.14140

  15. Emile J.F., Abla O., Fraitag S., Horne A.,Haroche J., Donadieu J., et al. HistiocyteSociety. Revised classification of histiocytosesand neoplasms of the macrophagedendriticcell lineages. Blood. 2016 Jun 2;127 (22): 2672-81. doi: 10.1182/blood-2016-01-690636

  16. Leung A.K., Lam J.M., Leong K.F. ChildhoodLangerhans cell histiocytosis: a diseasewith many faces. World Journal of Pediatrics,2019; 1-10. doi: https://doi.org/10.1007/s12519-019-00304-9

  17. Thacker N.H., Abla O. Pediatric Langerhanscell histiocytosis: state of the science andfuture directions. Clin Adv Hematol Oncol.2019;17: 122-31.

  18. Rodriguez G.C., Allen C.E. Langerhanscell histiocytosis. Blood 2020; 135 (16):1319-1331. doi: 10.1182/blood.2019CM0000

  19. Neves-Silva R., Fernandes D.T., Fonseca F.P.,Rebelo P.H.A., Ferreira B.B., Santos-SilvaR.A., et al. Oral manifestations of Langerhanscell histiocytosis: A case series. SpecCare Dentist. 2018; 38: 426-433. https://doi.org/10.1111/scd.12330

  20. Goyal G., Shah M.V., Hook C.C., et al. Adultdisseminated Langerhans cell histiocytosis:incidence, racial disparities and long-termoutcomes. Br J Haematol. 2018; 182 (4):579-581. doi:10.1111/bjh.14818

  21. Ribeiro K.B., Degar B., Antoneli C.B.G.,Rollins B., Rodriguez-Galindo C. Ethnicity,race, and socioeconomic status influenceincidence of Langerhans cell histiocytosis.Pediatr Blood Cancer. 2015; 62 (6): 982-987.doi:10.1002/pbc.25404

  22. Chow T.W., Leung W.K., Cheng F.W.T.,Kumta S.M., Chu W.C.W., Lee V., Li C.K.,et al. Late outcomes in children with Langerhanscell histiocytosis. Arch Dis Child. 2017;102 (9): 830-835.

  23. Merglová V., Hrušák D., Boudova L.,Mukenšnabl P., Valentová E., HostičkaL. Langerhans cell histiocytosis in childhood–Review, symptoms in the oralcavity, differential diagnosis and report oftwo cases.J Craniomaxillofac Surg. 2014;42 (2), 93-100. http://dx.doi.org/10.1016/j.jcms.2013.03.005




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