García MKA, Chávez GRD, Peraza GFJ

Language: Spanish
References: 15
Page: 40-48
PDF size: 237.55 Kb.

ABSTRACT

Objective: To determine the changes in intraocular pressure and ganglion cell complex in the three trimesters of pregnancy and in nonpregnant control patients. Material and Methods: Both variables (intraocular pressure and retinal ganglion cell complex) were analyzed in a group of pregnant patients who underwent measurements each trimester of pregnancy to subsequently compare the results with those of healthy non-pregnant patients assessed. in three consecutive quarters. According to an equivalence of means test, a sample of size n=37 was required in the reference group and in the control group, with a power of 80% and a significance of 5%. The database of the SPSS program was used for the organization, coding and statistical analysis of the results. Results: the findings of this study differ from what is described in the literature in which a tendency towards a decrease in intraocular pressure is mentioned; In this study, there was no clinical or statistically significant variation during pregnancy compared to non-pregnant patients. Neither clinically nor statistically significant variation was observed in the retinal ganglion cell complex. Conclusions: The patients studied did not have a diagnosis of glaucoma, which means that the results cannot be extrapolated to a group with the pathology, but they allow us to know the evolution of the retinal ganglion cell complex and intraocular pressure during pregnancy, a question important since there are few studies that analyze this information.

REFERENCES

1. Hamilton WD, Henderson PA, Moran NA.The pathophysiology and treatment of glaucoma:a review. Nat Sel Soc Behav (Eds RD Alexander D W Tinkle), Chiron Press NewYork. 1981;311(18):363–81

2. American Academy of Ophthalmology. Glaucoma:Introduction to Glaucoma. Am AcadOphthalmol. 2011;24–7.

3. Addepalli UK, Jonnadula GB, Garudadri CS,Rao HL, Rani PK, Chakrabarti S, et al. LVPrasad eye institute glaucoma epidemiologyand molecular genetic study (LVPEIGLEAMS).Report 1: Study design and researchmethodology. Ophthalmic Epidemiol.2013;20(3):188–95.

4. Cook C, Foster P. Epidemiology of glaucoma:What’s new? Can J Ophthalmol [Internet].2012;47(3):223–6. Available from:http://dx.doi.org/10.1016/j.jcjo.2012.02.00.

5. Cohen LP, Pasquale LR. Clinical characteristicsand current treatment of glaucoma.Cold Spring Harb Perspect Med. 2014;4(6).

6. Shin YU, Hong EH, Kang MH, Cho H, SeongM. The Association between Female ReproductiveFactors and Open-Angle Glaucomain Korean Women : The Korean NationalHealth and Nutrition Examination Survey V.2018;2018.

7. Ahmad SS. Glaucoma suspect : A PraticalApproach. Taiwan J Ophthalmol. 2017;8:53–5.

8. Serna-Ojeda JC, Flores-Reyes EM, Hartleben-Matkin C. Glaucoma: Corrientes en estudiosobre su etiología. Gac Med Mex.2014;150:317–23.

9. Diez RC, Román JJ, Barbosab MJI. Conceptode sospecha de glaucoma de ánguloabierto: Definición, diagnóstico y tratamiento.Rev Mex Oftalmol. 2014;88(4):153–60.

10. Likhvantseva VG, Sokolov VA, LevanovaON K. Predicting the probability of developmentand progression of primary open angleglaucoma by regression modeling. Vestn Oftalmol.2018;134(3):35–41.

11. Hollands, H., Johnson, D., Hollands, S., Simel,D. L., Jinapriya, D., & Sharma, S.(2013). Do findings on routine examinationidentify patients at risk for primary open-angleglaucoma?: The rational clinical examinationsystematic review. JAMA, 309(19),2035-2042.

12. Guglielmi P, Carradori S, Campestre C,Poce G. Novel therapies for glaucoma: a patentreview (2013-2019). Expert Opin TherPat [Internet]. 2019;29(10):769–80.

13. Savino PJ, Johnson SM, Martinez M, FreedmanS. Management of Glaucoma in Pregnancyand Lactation. 2001;45(5).

14. Pasquale LR, Grosskreutz CL. The Courseof Glaucoma During Pregnancy. Arch Ophthalmol.2016;124(1):1089–94.

15. Drake, S. C., & Vajaranant, T. S. (2016). Evidence-based approaches to glaucoma managementduring pregnancy and lactation.Current ophthalmology reports, 4(4), 198-205.