Quirós CK, Ching CA, Rosales VM

Language: Spanish
References: 17
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ABSTRACT

Meningiomas are the most common primary intracranial tumor of the central nervous system. For the most part, they´re benign, appearing typically in adulthood and the female population. Meningiomas arise from meningothelial (arachnoid) cells, with tendency locate at the level of the skull´s base. The World Health Organization classification for meningiomas, commonly known as “WHO” classification, represents a fundamental tool for determining prognosis, recurrence rate, and decision-making, regarding the overall management of these patients. This classification is based on the histopathological characteristics of the tumor, classifying them into three grades; the greater the Grade, the fewer therapeutic options and less favorable outcome. A series of molecular profiles and genetic aberrations have been correlated with these degrees; allowing stratification based on cytogenetic findings. However, these profiles have yet to be considered in the latest update of the classification. Definitive diagnosis is based on histopathology, but initially magnetic resonance imaging (MRI) represents the study of choice for identification and follow-up of meningiomas. The clinical presentation of meningiomas is often non-specific, and the physical exam tends to be unremarkable in most cases. Treatment for meningiomas is essentially determined by the meningiomas grade and is highly individualized. It includes a combination of observation, surgical resection, and radiotherapy (RT). Prognosis is predominantly determined by gross total resection and histopathology. The Simpson Grade System, correlates these elements in order to estimate the rate of recurrence after surgery. Advances in fields such as neuroimaging, radiology and neurosurgery; have allowed a higher degree of gross total resection to be achieved, improving the prognosis and survival rates of these patients. This review provides an overview of the genetic basis, general evaluation, and treatment for these tumors.

REFERENCES

1. Pérez Castro y Vázquez JA, Díaz Echevarría A, Barrios Calyecac DY, Lara Moctezuma L. Presentación de un meningioma con síntomas iniciales oftalmológicos. Rev. Fac. Med. (Méx.) [Internet]. Octubre, 2018. [Citado el 27 de abril del 2022]; 61(5):32-43. Disponible a partir de:http://www.scielo.org.mx/scielo.php?script=sci_arttext&pid=S0026-17422018000500032&lng=es

2. Ogasawara C, Philbrick BD, Adamson DC. Meningioma: A Review of Epidemiology, Pathology, Diagnosis, Treatment, and Future Directions. Biomedicines 2021. [Internet] [cited Apr 05, 2022] Doi: https://doi.org/10.3390/ biomedicines9030319

3. Park K. Epidemiology, Pathology, clinical features, and diagnosis of meningioma. Post TW, ed. UpToDate. Waltham, MA: UpToDate Inc. [Internet] June, 2022 [cited Apr 24, 2022]. Available from: https://www.uptodate.com/contents/epidemiology-pathology-clinical-features-and-diagnosis-of-meningioma

4. Goldbrunner R, Stavrinou P, Jenkinson MD, Sahm F, Mawrin C, Weber DC, et al. EANO guideline on the diagnosis and management of meningiomas. Neuro Oncol [Internet]. 2021[cited May 03, 22];23(11):1821–34. Doi: http://dx.doi.org/10.1093/neuonc/noab150

5. Buerki RA, Horbinski CM, Kruser T, Horowitz PM, James CD, Lukas RV. An overview of meningiomas. Future Oncol [Internet]. 2018[cited Apr 20, 2022];14(21):2161–77. Doi: http://dx.doi.org/10.2217/fon-2018-0006

6. Álvarez Pinzón AM. Evaluación clínica de meningioma intraventricular: reporte de caso paciente pediátrico y paciente adulto. Rev Med [Internet]. 2017 [cited Apr 24, 2022];25(1):78–86. Doi: http://dx.doi.org/10.18359/rmed.2923

7. DiGiorgio AM, Virk MS, Mummaneni PV. Spinal meningiomas. Handb Clin Neurol [Internet]. 2020 [citado el 24 de abril del 22];170:251–6. Doi: http://dx.doi.org/10.1016/B978-0-12-822198-3.00045-8

8. Nowosielski M, Galldiks N, Iglseder S, Kickingereder P, von Deimling A, Bendszus M, et al. Diagnostic challenges in meningioma. Neuro Oncol [Internet]. 2017 [cited Apr 01, 2022];19(12):1588–98. Doi: http://dx.doi.org/10.1093/neuonc/nox101

9. Lee YS, Lee YS. Molecular characteristics of meningiomas. J Pathol Transl Med [Internet]. 2020 [cited May 02, 2022];54(1):45–63. Doi: http://dx.doi.org/10.4132/jptm.2019.11.05

10. Shih H, Park K. Management of atypical and malignant (WHO Grade 2 and 3) meningioma.UpToDate, Post, TW (Ed), UpToDate, Waltham, MA, 2021. [Internet]. Oct 01, 2021 [cited Apr 01, 2022]. Available from : https://www.uptodate.com/contents/management-of-atypical-and-malignant-who-grade-2-and-3-meningioma

11. Eric T Wong, Julian K Wu, Overview of the clinical features and diagnosis of braintumors in adults. UpToDate, Post, TW (Ed), UpToDate, Waltham, MA, 2020. [Internet]. Dec 07, 2021 [cited Apr 29 2022). Available from: https://www.uptodate.com/contents/overview-of-the-clinical-features-and-diagnosis-of-brain-tumors-in-adults

12. Apostolov G, Kehayov I, Kitov B. Clinical aspects of spinal meningiomas: A review. Folia Med (Plovdiv) [Internet]. 2021 [cited May 02, 2022];63(1):249. Doi: http://dx.doi.org/10.3897/folmed.63.e52967

13. Pinzi V, Bisogno I, Prada F, Ciusani E, Fariselli L. Radiotherapy of meningioma: a treatment in need of radiobiological research. Int J Radiat Biol [Internet]. 2018 [cited May 02, 2022];94(7):621–7. Doi: http://dx.doi.org/10.1080/09553002.2018.1478157

14. Park JK, Shih H. Management of known or presumed benign (WHO grade 1) meningioma. UpToDate, Post, TW (Ed), UpToDate Waltham, MA, 2021. [Internet] [cited Apr 01, 2022]. Available from: https://www.uptodate.com/contents/management-of-known-or-presumed-benign-who-grade-1-meningioma

15. Pikis S, Bunevicius A, Sheehan J. Outcomes from treatment of asymptomatic skull base meningioma with stereotactic radiosurgery. Acta Neurochir (Wien) [Internet]. 2021 [cited May 03, 2022];163(1):83–8. Doi: http://dx.doi.org/10.1007/s00701-020-04648-4

16. Ajler P, Beltrame S, Massa D, Tramontano J, Baccanelli M, Yampolsky C. Relevancia de los grados de Simpson en la resección de meningiomas grado I. Surg Neurol Int [Internet]. 2017;8(3):5 [citado el 02 de mayo, 2022]. Doi: http://dx.doi.org/10.4103/sni.sni_84_17

17. Rae-Grant A, Erlich Alan MD. Meningiomas, Complications and Prognosis. EBSCO Information Services, Dynamed. [Internet]. June, 2021 [cited May 04, 2022]. Available from: https://www.dynamed.com/condition/meningioma