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Colegio de Medicina Interna de México.
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2022, Number 4

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Med Int Mex 2022; 38 (4)

Medullar damage in posterior horns, initial manifestation of multiple myeloma

Rodríguez-Ojeda A, Aguas-Arce F, García-González J, Banda-García L
Full text How to cite this article

Language: Spanish
References: 6
Page: 942-947
PDF size: 440.10 Kb.


Key words:

Multiple myeloma, Bone disease.

ABSTRACT

Background: Multiple myeloma is a severe hematologic malignancy characterized by the presence of plasma cells producing a monoclonal immunoglobulin with bone marrow infiltration. The most common presentation symptom (67%) was bone pain. The most common complications present in the diagnosis were anemia (54%), bone disease (45%) and renal failure (36%); although the affectations at the level of the central nervous system have been considered infrequent but not non-existent variables. The clinical presentation found in the variants associated with infiltration of the central nervous system is characterized by presenting paresis and dysesthesias directly proportional to the percentage of nervous disorders.
Clinical case: A 39-year-old female patient with medullar affection in posterior horns as initial manifestation of multiple myeloma.
Conclusions: In Mexico, the statistics of this type of disease have been deficient; however, it is sought to guide in a timely manner and make a differential diagnosis to avoid complications derived from the underlying disease.


REFERENCES

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  2. Xiao-Yan Q, Wei-Jun F, Xao X, Fan X, et al. Clinical featuresof multiple myeloma invasion of the central nervous systemin Chinese patients. Chin Med J 2010; 123 (11): 1402-1406.

  3. Jurczyszyn A, Grzasko N, Gozzetti A, Czepiel J, et al. Centralnervous system involvement by multiple myeloma: Amulti-institutional retrospective study of 172 patients indaily clinical practice. Am J Hematol 2016; 91: 575-580.doi: 10.1002/ajh.24351.

  4. Ruiz-Argüelles GJ, Gomez-Rangel JD, Ruiz- Delgado GJ,Aguilar-Romero L. Multiple myeloma in Mexico: a 20-yearexperience at a single institution. Arch Med Res 2004; 35:163-167. doi: 10.1016/j.arcmed.2003.09.013.

  5. Rodríguez-Nava MA, Soto-Rivas I, Hernández-Meraz O.Síndrome de compresión medular y mieloma múltiple inicialmentemal diagnosticados. Med Int Mex 2013; 29: 318-323.

  6. Varettoni M, Corso A, Zappasodi P, Calliada F, Castagnola C,Mangiacavalli S, Lazzarino M. Infiltration of the spinal cordin a patient with multiple myeloma. J Clin Oncol 2008; 26(25): 4207-4209. doi: 10.1200/JCO.2008.16.8476.




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Med Int Mex. 2022;38