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Asociación Colombiana de Otorrinolaringología y Cirugía de Cabeza y cuello, Maxilofacial y Estética Facial (ACORL)

2021, Number 1

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Acta de Otorrinolaringología CCC 2021; 49 (1)

Relevant mechanisms and pathways in the transmission of SARS-CoV-2 infection

Vanegas BN, Ariza AAT, González-Marín NR

Language: Spanish
References: 31
Page: 28-35
PDF size: 250.45 Kb.


ABSTRACT

Introduction: The type of betacoronavirus that causes the disease COVID-19 is called SARS-CoV-2, it has presented a rapid expansion worldwide, currently generating a public health emergency. Different causes can explain this behavior, such as the type of transmission, which has been debated, with different positions regarding the involvement of aerosol and extrapulmonary pathways. Objective: Consolidate information of the different mechanisms and transmission routes of SARS-CoV-2. Methodology: A narrative review of the literature was carried out with a systematic search in databases such as Pubmed, Embase, ScienceDirect, MEDLINE, CENTRAL and Literatura Latinoamericana y del Caribe en Ciencias de la Salud (LILACS). With MeSH terms “Transmission”, “Aerosol”, “Betacoronavirus” applying inclusion and exclusion criteria, as well as critical reading with the CASPe tool, 31 articles were selected. Results: The transmission of the virus occurs by contact with drops, fomites and aerosolization, favoring air infection and its permanence even up to 8 hours, being a propagator of the disease. The transmission by blood and fecal contact, is not frequent, but in cases such as performing procedures or requiring a transfusion, are relevant and measures must be taken. Conclusions: All patients should be considered potential transmitting and both mechanical and self-induced aerosol induction should be considered, without requiring an important manipulation of the airway for virus aerosolization and transmission. The measures for the management of the environment must be considered, as well as the possibility of transmission by extrapulmonary route, such as blood and orofecal route.


REFERENCES

  1. Shereen M, Khan S, Kazmi A, Bashir N, Siddique R. COVID-19infection: Origin, transmission, and characteristics of humancoronaviruses. Journal of Advanced Research. 2020;24:91-8.doi: 10.1016/j.jare.2020.03.005

  2. Li X, Xu S, Yu M, Wang K, Tao Y, Zhou Y, et al. Risk factors forseverity and mortality in adult COVID-19 inpatients in Wuhan.J Allergy Clin Immunol. 2020;146(1):110-8. doi: 10.1016/j.jaci.2020.04.006.

  3. Wu Z, McGoogan JM. Characteristics of and ImportantLessons From the Coronavirus Disease 2019 (COVID-19)Outbreak in China: Summary of a Report of 72 314 Cases Fromthe Chinese Center for Disease Control and Prevention. JAMA.2020;323(13):1239-42. doi: 10.1001/jama.2020.2648

  4. Xu K, Lai XQ, Liu Z. [Suggestions for prevention of 2019novel coronavirus infection in otolaryngology head andneck surgery medical staff]. Zhonghua Er Bi Yan HouTou Jing Wai Ke Za Zhi. 2020;55(0):E001. doi: 10.3760/cma.j.issn.1673-0860.2020.0001

  5. Kowalski LP, Sanabria A, Ridge JA, Ng WT, de Bree R,Rinaldo A, et al. COVID-19 pandemic: Effects and evidencebasedrecommendations for otolaryngology and head andneck surgery practice. Head Neck. 2020;42(6):1259-67. doi:10.1002/hed.26164

  6. Han Y, Yang H. The transmission and diagnosis of 2019novel coronavirus infection disease (COVID‐19): A Chineseperspective. J Med Virol. 2020;92:639-44. doi: 10.1002/jmv.25749.

  7. Chan JYK, Wong EWY, Lam W. Practical Aspects ofOtolaryngologic Clinical Services During the 2019 NovelCoronavirus Epidemic: An Experience in Hong Kong. JAMAOtolaryngol Head Neck Surg. 2020;146(6):519-20. doi:10.1001/jamaoto.2020.0488

  8. Javid B, Weekes MP, Matheson NJ. Covid-19: should thepublic wear face masks? BMJ. 2020;369:m1442. doi: 10.1136/bmj.m1442

  9. Terpos E, Ntanasis-Stathopoulos I, Elalamy I, Kastritis E,Sergentanis TN, Politou M, et al. Hematological findings andcomplications of COVID-19. Am J Hematol. 2020;95(7):834-47. doi: 10.1002/ajh.25829

  10. Li LQ, Huang T, Wang YQ, Wang ZP, Liang Y, Huang TB, et al.COVID-19 patients’ clinical characteristics, discharge rate, andfatality rate of meta-analysis. J Med Virol. 2020;92(6):577-83.doi: 10.1002/jmv.25757

  11. World Health Organization [Internet]. WHO; 2020. Report ofthe WHO-China Joint Mission on Coronavirus Disease 2019(COVID-19). [actualizado 24 de febrero de 2020]. Disponibleen: https://www.who.int/docs/default-source/coronaviruse/who-china-joint-mission-on-covid-19-final-report.pdf

  12. World Health Organization [Internet]. Infection preventionand control during health care when novel coronavirus (nCoV)infection is suspected. WHO; 2020. [actualizado 19 de marzo de2020]. Disponible en: https://www.who.int/publications-detail/infection-prevention-and-control-during-health-care-whennovel-coronavirus-(ncov)-infection-is-suspected-20200125

  13. Vukkadala, N., Qian, Z., Holsinger, F., Patel, Z., & Rosenthal,E. (2020). COVID-19 and the Otolaryngologist: PreliminaryEvidence Based Review. The Laryngoscope, 130(11), 2537-2543. doi: 10.1002/lary.28672

  14. Workman AD, Welling DB, Carter BS, Curry WT, Holbrook EH,Gray ST, et al. Endonasal instrumentation and aerosolizationrisk in the era of COVID-19: simulation, literature review,and proposed mitigation strategies. Int Forum Allergy Rhinol.2020;10(7):798-05. doi: 10.1002/alr.22577

  15. Lüers J, Klußmann J, Guntinas-Lichius O. Die COVID-19-Pandemie und das HNO-Fachgebiet: Worauf kommt es aktuellan? Laryngo-Rhino-Otologie. 2020;99(5):1-5. doi: 10.1055/a-1095-2344

  16. van Doremalen N, Bushmaker T, Morris DH, Holbrook MG,Gamble A, Williamson BN, et al. Aerosol and Surface Stabilityof SARS-CoV-2 as Compared with SARS-CoV-1. N Engl JMed. 2020;382(16):1564-67. doi: 10.1056/NEJMc2004973

  17. Wang J, Du G. COVID-19 may transmit through aerosol. IrJ Med Sci. 2020;189(4):1143-44. doi: 10.1007/s11845-020-02218-2

  18. Peng X, Xu X, Li Y, Cheng L, Zhou X, Ren B. Transmissionroutes of 2019-nCoV and controls in dental practice.International Journal of Oral Science. 2020;12(9):1-6. doi:10.1038/s41368-020-0075-9

  19. Ong SWX, Tan YK, Chia PY, Lee TH, Ng OT, Wong MSY, et al.Air, Surface Environmental, and Personal Protective EquipmentContamination by Severe Acute Respiratory SyndromeCoronavirus 2 (SARS-CoV-2) From a Symptomatic Patient.JAMA. 2020;323(16):1610-12. doi: 10.1001/jama.2020.3227

  20. Lavinsky, J., Kosugi, E., Baptistella, E., Roithmann, R., Dolci,E., & Ribeiro, T. et al. (2020). An update on COVID-19for the otorhinolaryngologist – a Brazilian Association ofOtolaryngology and Cervicofacial Surgery (ABORL-CCF)Position Statement. Brazilian Journal Of Otorhinolaryngology,86(3), 273-280. doi: 10.1016/j.bjorl.2020.04.002

  21. McIntosh K, Hirsh MS, Bloom A. Coronavirus disease 2019(COVID-19): Epidemiology, virology, clinical features,diagnosis, and prevention. [Actualizada 18 de febrerode 2021]. UpToDate; 2021. Disponible en: https://www.uptodate.com/contents/coronavirus-disease-2019-covid-19-epidemiology-virology-clinical-features-diagnosis-andprevention?search=COVID%2019&source=search_result&selectedTitle=1~150&usage_type=default&display_rank=1

  22. Guo YR, Cao QD, Hong ZS, Tan YY, Chen SD, Jin HJ, et al.The origin, transmission and clinical therapies on coronavirusdisease 2019 (COVID-19) outbreak - an update on the status.Mil Med Res. 2020;7(1):11. doi: 10.1186/s40779-020-00240-0

  23. Chang L, Yan Y, Wang L. Coronavirus Disease 2019:Coronaviruses and Blood Safety. Transfus Med Rev.2020;34(2):75-80. doi: 10.1016/j.tmrv.2020.02.003

  24. Meng X, Huang X, Zhou P, Li C, Wu A. Alert for SARS-CoV-2infection caused by fecal aerosols in rural areas in China.Infect Control Hosp Epidemiol. 2020;41(8):987. doi: 10.1017/ice.2020.114

  25. Wang W, Xu Y, Gao R, Lu R, Han K, Wu G, et al. Detectionof SARS-CoV-2 in Different Types of Clinical Specimens.JAMA. 2020;323(18):1843-44. doi: 10.1001/jama.2020.3786

  26. Zou L, Ruan F, Huang M, Liang L, Huang H, Hong Z, et al.SARS-CoV-2 Viral Load in Upper Respiratory Specimens ofInfected Patients. N Engl J Med. 2020;382(12):1177-79. doi:10.1056/NEJMc2001737

  27. Boccalatte LA, Larrañaga JJ, Perez Raffo GM, TeijidoCA, García Fornari G, Staneloni MI, et al. Brief guidelinefor the prevention of COVID-19 infection in head andneck and otolaryngology surgeons. Am J Otolaryngol.2020;41(3):102484. doi: 10.1016/j.amjoto.2020.102484

  28. Balibrea JM, Badia JM, Rubio Pérez I, Martín Antona E,Álvarez Peña E, García Botella S, et al. Surgical Managementof Patients With COVID-19 Infection. Recommendations ofthe Spanish Association of Surgeons. Cir Esp. 2020;98(5):251-259. doi: 10.1016/j.ciresp.2020.03.001

  29. Government of Canada [Internet]. Infection prevention andcontrol for coronavirus disease (COVID-19): Interim guidancefor acute healthcare settings. Canada.ca; 2020. [Acceso 24de febrero de 2020]. Disponible en: https://www.canada.ca/en/public-health/services/diseases/2019-novel-coronavirusinfection/health-professionals/interim-guidance-acutehealthcare-settings.html

  30. Wax RS, Christian MD. Practical recommendations for criticalcare and anesthesiology teams caring for novel coronavirus(2019-nCoV) patients. Can J Anaesth. 2020;67(5):568-76. doi:10.1007/s12630-020-01591-x

  31. Zhang, H., Kang, Z., Gong, H., Xu, D., Wang, J., & Li, Z. etal. (2020). The digestive system is a potential route of 2019-nCov infection: a bioinformatics analysis based on single-celltranscriptomes. doi: 10.1101/2020.01.30.927806




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