medigraphic.com
ISSN 2007-6800 (Print)

2023, Number 1

<< Back

Rev Mex Traspl 2023; 12 (1)

Endothelial corneal rejection in a patient with penetrating keratoplasty, two non-simultaneous episodes following messenger ARN immunization against SARS-CoV-2 in San Luis Potosí

Guevara-Venzor LF, González-González JF, Ramírez-Villagrán B, Tello-Medina RI

Language: Spanish
References: 20
Page: 50-58
PDF size: 293.97 Kb.


ABSTRACT

The SARS-CoV-2 pandemic decreased the corneal transplants performed annually. Since 2020, health organizations have developed campaigns against the virus, promote vaccination and the guidelines have been adjusting for the reactivation of transplant programs. Several ophthalmologic manifestations have been associated to the different types of vaccines against SARS-CoV-2. We report a case of a 28-year-old male patient with bilateral penetrating keratoplasty; the patient had two doses of BNT162b2 mRNA SARS-CoV-2 vaccine, 3 months later of the left eye surgery. After two days of each vaccine, he presented the following signs and symptoms: decrease in visual acuity of 4 lines in Snellen test and in anterior segment, Khodadoust line was found in the cornea, this feature is characteristic of acute endothelial rejection of the allograft in the left eye. The treatment with corticosteroids was successful in both episodes. This is the first case of two episodes of acute endothelial rejection in a patient with penetrating keratoplasty in the same eye, associated with immunization with BNT162b2 mRNA SARS-CoV-2. Doctors and patients with corneal transplant should know the secondary effects of the vaccination of SARS-CoV-2 to receive a treatment in a timely manner and guarantee the corneal graft survival and preserve life quality of the patient.


REFERENCES

  1. Boletín Estadístico Informativo Centro Nacional de Trasplantes (BEI-CENATRA) Derecho a la protección de la salud y los trasplantes de órganos y tejidos. [Internet]. Vol. IV. Romero-Méndez, Josefina; 2019. p. 1-72. Disponible en: https://twitter.com/landsteinermx/status/1092839443743064064?lang=nl

  2. Reporte Anual 2019 de donación y trasplante en México. San Luis Potosí; 2020.

  3. Sachdeva GS, Cabada JP, Karim SS, Kahandawa DL, Thomas KA, Kumar A et al. Effectiveness of matching human leukocyte antigens (HLA) in corneal transplantation: a systematic review protocol. Syst Rev. 2021; 10 (1): 150.

  4. Tello-Medina RI, Monsiváis-Santoyo TG, Gámez-Gómez E. Procuración de tejido corneal y banco de ojos en época de COVID-19 en el estado de San Luis Potosí, México. Rev Mex Traspl. 2021; 10 (1): 29-33.

  5. Centro Nacional de Trasplantes. Boletín Estadístico- Informativo del Centro Nacional de TrasplantesFinal Bei Cenatra 2022 [Internet]. Ciudad de México; 2022 [Citado 06 Septiembre 2022]. Disponible en: https://es.calameo.com/read/0064851944a2da272ea10

  6. Luisa Ruiz-Morales M, Verdiguel-Sotelo K, Hernández-López A. Frecuencia del queratocono y trasplante de córnea Práctica Clínico-Quirúrgica Resumen. Rev Med Inst Mex Seguro Soc. 2010; 48 (3): 309-312.

  7. Rasik V. Trasplante de córnea. Panamá: Highlights of Ophthalmology International; 2002.

  8. Parmar D, Garde P, Shah S, Bhole P. Acute graft rejection in a high-risk corneal transplant following COVID-19 vaccination: a case report. Indian J Ophthalmol. 2021; 69 (12): 3757-3758.

  9. Niederkorn JY. Corneal transplantation and immune privilege. Int Rev Immunol. 2013; 32 (1): 57-67.

  10. Major J, Foroncewicz B, Szaflik JP, Mucha K. Immunology and donor-specific antibodies in corneal transplantation. Arch Immunol Ther Exp (Warsz). 2021; 69 (1): 1-10.

  11. Lin TPH, Ko CN, Zheng K, Lai KHW, Wong RLM, Lee A et al. COVID-19: Update on Its Ocular Involvements, and Complications From Its Treatments and Vaccinations. Vol. 10, Asia-Pacific journal of ophthalmology (Philadelphia, Pa.). NLM (Medline); 2021. p. 521-529.

  12. Phylactou M, Li JPO, Larkin DFP. Characteristics of endothelial corneal transplant rejection following immunisation with SARS-CoV-2 messenger RNA vaccine. Br J Ophthalmol. 2021; 105 (7): 893-896.

  13. Molero-Senosiain M, Houben I, Savant S, Savant V. Five cases of corneal graft rejection after recent COVID-19 vaccinations and a review of the literature. Cornea. 2022; 41 (5): 669-672. Available from: www.corneajrnl.com

  14. Centro D, de Trasplantes N. Boletín Estadístico-Informativo BEI-CENATRA Quinto Aniversario.

  15. Sen M, Honavar S. After the storm: ophthalmic manifestations of COVID-19 vaccines. Indian J Ophthalmol. 2021; 69 (12): 3398-3420.

  16. Ravichandran S, Natarajan R. Corneal graft rejection after COVID-19 vaccination. Indian J Ophthalmol. 2021; 69 (7): 1953-1954.

  17. Rallis KI, Ting DSJ, Said DG, Dua HS. Corneal graft rejection following COVID-19 vaccine. Eye (Lond). 2022; 36 (6): 1319-1320.

  18. Rajagopal R, Priyanka T. Stromal rejection in penetrating keratoplasty following COVID-19 vector vaccine (Covishield) - A case report and review of literature. Indian J Ophthalmol. 2022; 70 (1): 319-321.

  19. Crnej A, Khoueir Z, Cherfan G, Saad A. Acute corneal endothelial graft rejection following COVID-19 vaccination. J Fr Ophtalmol. 2021; 44 (8): e445-e447.

  20. Wasser LM, Roditi E, Zadok D, Berkowitz L, Weill Y. Keratoplasty rejection after the BNT162b2 messenger RNA vaccine. Cornea. 2021; 40 (8): 1070-1072. Available in: ncbi.nlm.nih.gov/pmc/articles/PMC8244807/




2020     |     www.medigraphic.com