2022, Number 2
Chemical study of Annona scleroderma and Annona globiflora plants as a source of cytotoxic compounds
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Language: Spanish
References: 26
Page: 25-39
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ABSTRACT
Introduction: cancer is one of the most frequent causes of death in the world population of the 21st century. In Mexico, since 1995 it became the second cause of death, with an incidence of 12%; given this scenario, various strategies are being addressed for the design of drugs that allow establishing an effective treatment against this pathology. One of these strategies is the search for natural molecules that can be developed as anticancer drugs. Objective: to evaluate the anticancer activity of the Kupchan fractions of Annona scleroderma and Annona globiflora on human cancer cell lines, HBL-100, HeLa, SW1573, T-47D and WiDr, and to purify their main compounds. Materials and methods: A. scleroderma and A. globiflora seeds were extracted with methanol. The methanolic extract was fractionated by the Kupchan method and these fractions were tested against five cancer cell lines using the XTT assay. Various chromatographic techniques were used for the purification of the active fractions. Results: evaluations of the Kupchan fractions against five cancer lines indicate that the hex ane and dichloromethane fractions of both species have remarkable activity against all cell lines, while the other Kupchan fractions showed little activity (‹50% inhibition). The phytochemical study of these plants allowed the isolation of the compounds, squamins C-F (1-4), rolliniastatin 2 (5) and bullatacinone (6). Conclusions: Based on the results obtained, it is clear that the A. scleroderma and A. globiflora plants have great potential as a source of cytotoxic compounds that could lay the groundwork for the development of new anticancer drugs. Thus, for example, the compounds isolated from these plants, squamins C-F (1-4), rolliniastatin 2 (5) and bullatacinone (6) have marked activity against several cancer cell lines.REFERENCES
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