medigraphic.com
SPANISH

Archivos de Medicina

Archivos de Medicina (Manizales)
  • Contents
  • View Archive
  • Information
    • General Information        
    • Directory
  • Publish
    • Instructions for authors        
  • medigraphic.com
    • Home
    • Journals index            
    • Register / Login
  • Mi perfil

2022, Number 2

<< Back Next >>

Arch Med 2022; 22 (2)

Work stress in residents of medical-surgical specialties and its relationship with the inflammatory state

Burbano-Obando JP, Sánchez-Sánchez JP, Álvarez-Soler JA, Dueñas-Cuellar RA, Niño-Castaño VE, Ávila-González GI, Merchán-Galvis ÁM
Full text How to cite this article

Language: Spanish
References: 40
Page: 230-241
PDF size: 376.87 Kb.


Key words:

Burnout, Cytokines, Medicine, Health Postgraduate Programs.

ABSTRACT

Introduction: residents of medical-surgical specialties are a population at risk of developing Burnout syndrome, which negatively affects their health and, consequently, triggers alterations in serum cytokine levels that lead to an inflammatory state. Objective: to assess work stress through the diagnosis of Burnout syndrome and pro and anti-inflammatory cytokine levels in first year residents of the Universidad del Cauca. Materials and Methods: a prospective longitudinal descriptive study was carried out in a population of 14 medical residents. It was used selfcompleted surveys to evaluate sociodemographic, clinical and residence variables; as well as, the Zung test and the Maslach Burnout Inventory to assess the presence of Burnout syndrome. Additionally, venous blood samples were taken to measure the production of pro- and anti-inflammatory cytokines using the ELISA technique, at the beginning, six months and one year (three samples) at the beginning of the medical residency. Results: he 100% of the population presented alterations in any of the dimensions associated with Burnout syndrome, among which predominated was emotional exhaustion. In the end of the follow-up, 14.3% of the residents presented Burnout and a significant decrease in TNF-α production was observed. Conclusion: this study evidences the possibility of the appearance of burnout syndrome in students of medical-surgical specialization due to exposure to chronic stressors associated with academic and emotional conditions. Similarly, this research demonstrates a disease in the inflammatory state of residents, which in the long term that could affect health.


REFERENCES

  1. Ali M, Asim H, Edhi AI, Hashmi MD, Khan MS, Naz F, et al. Does academic assessment system type affectlevels of academic stress in medical students? A cross-sectional study from Pakistan. Medical educationonline. Taylor & Francis. 2015;20:27706. https://doi.org/10.3402/meo.v20.27706

  2. Almeida DM, Wethington E, Kessler RC. The daily inventory of stressful events: An interview-based approachfor measuring daily stressors. Assessment. Sage Publications Sage CA: Thousand Oaks, CA. 2002;9:41-55.https://doi.org/10.1177/1073191102091006

  3. Griffiths A, Leka S, Cox T. La organización del trabajo y el estrés: estrategias sistemáticas de solución deproblemas para empleadores, personal directivo y representantes sindicales [Internet]. Ginebra: OrganizaciónMundial de la Salud; 2004 [citado 5 de mayo de 2022].Disponible en: https://apps.who.int/iris/bitstream/handle/10665/42756/9243590472.pdf

  4. Maslach C, Jackson SE, Cubero NS. MBI: Inventario” Burnout” de Maslach: Síndrome del quemado porestrés laboral asistencial: Manual. Tea; 1997.

  5. Córdoba L, Tamayo JA, González MA, Martínez MI, Rosales A, Barbato SH. Adaptation and validation of theMaslach Burnout inventory-human services survey in Cali, Colombia. Colombia Médica. 2011;42:286-293.

  6. Verweij H, van der Heijden FM, van Hooff ML, Prins JT, Lagro-Janssen AL, van Ravesteijn H, et al. The contributionof work characteristics, home characteristics and gender to burnout in medical residents. Advancesin Health Sciences Education. Springer. 2017;22:803-818. https://doi.org/10.1007/s10459-016-9710-9

  7. Nakata A. Psychosocial job stress and immunity: a systematic review. Psychoneuroimmunology. Springer.2012. p. 39-75.

  8. Gądek-Michalska A, Tadeusz J, Rachwalska P, Bugajski J. Cytokines, prostaglandins and nitric oxide in theregulation of stress-response systems. Pharmacological reports. 2013;65:1655-1662.https://doi.org/10.1016/S1734-1140(13)71527-5

  9. Segerstrom SC, Miller GE. Psychological stress and the human immune system: a meta-analytic study of30 years of inquiry. Psychological bulletin. American Psychological Association. 2004;130:601.

  10. Tian R, Hou G, Li D, Yuan T-F. A possible change process of inflammatory cytokines in the prolongedchronic stress and its ultimate implications for health. The Scientific World Journal. Hindawi; 2014:780616.https://doi.org/10.1155/2014/780616

  11. Penz M, Kirschbaum C, Buske-Kirschbaum A, Wekenborg MK, Miller R. Stressful life events predict one-yearchange of leukocyte composition in peripheral blood. Psychoneuroendocrinology. 2018;94:17-24.https://doi.org/10.1016/j.psyneuen.2018.05.006

  12. Campo-Arias A, Díaz-Martínez LA, Rueda-Jaimes GE, Barros-Bermúdez JA. Validación de la escala de Zungpara depresión en universitarias de Bucaramanga, Colombia. Revista Colombiana de Psiquiatría. AsociaciónColombiana de Psiquiatría; 2005;34:54-62.

  13. Antonelli A, Ferri C, Ferrari SM, Ghiri E, Goglia F, Pampana A, et al. Serum levels of proinflammatory cytokinesinterleukin-1β, interleukin-6, and tumor necrosis factor α in mixed cryoglobulinemia. Arthritis & Rheumatism:Official Journal of the American College of Rheumatology. 2009;60:3841-3847. https://doi.org/10.1002/art.25003

  14. O’Brien SM, Scully P, Fitzgerald P, Scott LV, Dinan TG. Plasma cytokine profiles in depressed patients whofail to respond to selective serotonin reuptake inhibitor therapy. Journal of psychiatric research. 2007;41:326-331. https://doi.org/10.1016/j.jpsychires.2006.05.013

  15. Sarmiento PJ, Chico AP. Calidad de vida en médicos en formación de posgrado. Persona y bioética.2015;19:290-302.

  16. Burbano Obando JP, Sánchez Sánchez JP, Mera Mamian AY. Biomarcadores de estrés laboral en residentes: artículode revisión. Revista de la Facultad de Ciencias de la Salud de la Universidad del Cauca. 2019;21(2):24-31.

  17. Berdejo Pacheco HL. Síndrome de desgaste laboral (burnout) en los médicos residentes de especialidadesmedico quirúrgicas de la universidad nacional de Colombia, sede Bogotá [Internet]. [Bogotá]: UniversidadNacional de Colombia; 2014 [citado 5 de mayo de 2020]. Disponible en:https://repositorio.unal.edu.co/bitstream/handle/unal/51658/05599120.2014.pdf?sequence=1&isAllowed=y

  18. Paredes OL, Sanabria-Ferrand PA. Prevalencia del síndrome de burnout en residentes de especialidadesmédico quirúrgicas, su relación con el bienestar psicológico y con variables sociodemográficas y laborales.Revista Med. Universidad Militar Nueva Granada. 2008;16:25-32.

  19. Elmore LC, Jeffe DB, Jin L, Awad MM, Turnbull IR. National survey of burnout among US general surgeryresidents. Journal of the American College of Surgeons. 2016;223:440-51.https://doi.org/10.1016/j.jamcollsurg.2016.05.014

  20. Hameed TK, Masuadi E, Al Asmary NA, Al-Anzi FG, Al Dubayee MS. A study of resident duty hours and burnoutin a sample of Saudi residents. BMC medical education. 2018;18:180. https://doi.org/10.1186/s12909-018-1300-5

  21. Waldman SV, Diez JCL, Arazi HC, Linetzky B, Guinjoan S, Grancelli H. Burnout, perceived stress, and depressionamong cardiology residents in Argentina. Academic Psychiatry. 2009;33:296-301.https://doi.org/10.1176/appi.ap.33.4.296

  22. Reyes Duque G, Ortiz Monsalve LC. Sistema de Residencias Médicas en Colombia: Marco conceptual parauna propuesta de regulación [Internet]. 2013 [citado 5 de mayo de 2022]. Disponible en:https://www.minsalud.gov.co/salud/Documents/Observatorio%20Talento%20Humano%20en%20Salud/Documento%20de%20Residencias%20M%C3%A9dicas_versi%C3%B3n%206%20(2).pdf

  23. Congreso de la República de Colombia. Ley 1616 por medio de la cual se expide la ley de Salud Mental y sedictan otras disposiciones. [Internet]. 2013 [citado 8 de julio de 2022]. Disponible en: http://wsp.presidencia.gov.co/Normativa/Leyes/Documents/2013/LEY%201616%20DEL%2021%20DE%20ENERO%20DE%202013.pdf

  24. Garcia Lourencao L, Camacho Moscardini A, Geraldes Soler ZAS. Health and quality of life of medical residents.Rev Assoc Med Bras. 2010;56:81-90. https://doi.org/10.1590/S0104-42302010000100021

  25. Pérez Cruz E. Síndrome de burnout como factor de riesgo de depresión en médicos residentes. MedicinaInterna de México. 2006;22:282-286.

  26. Butterfield PS. The stress of residency: a review of the literature. Archives of internal medicine. 1988;148:1428-1435.

  27. Merchán-Galvis ÁM, Albino Matiz AY, Bolaños-López JE, Millán N, Arias-Pinzón AA. Síndrome de Burnout yfactores asociados en estudiantes de Medicina. Educación Médica Superior. 2018;32:172-180.

  28. Borda Pérez M, Navarro Lechuga E, Aun Aun E, Berdejo Pacheco H, Racedo Rolón K, Ruiz Sará J. Síndromede Burnout en estudiantes de internado del Hospital Universidad del Norte. Revista Salud Uninorte.2007;23:43-51.

  29. Pantaleoni JL, Augustine EM, Sourkes BM, Bachrach LK. Burnout in pediatric residents over a 2-year period:a longitudinal study. Academic pediatrics. 2014;14:167-172. https://doi.org/10.1016/j.acap.2013.12.001

  30. Kopp MS, Thege BK, Balog P, Stauder A, Salavecz G, Rózsa S, et al. Measures of stress in epidemiologicalresearch. Journal of psychosomatic research. 2010;69:211-225. https://doi.org/10.1016/j.jpsychores.2009.09.006

  31. Kuebler U, Zuccarella-Hackl C, Arpagaus A, Wolf JM, Farahmand F, von Känel R, et al. Stress-induced modulationof NF-κB activation, inflammation-associated gene expression, and cytokine levels in blood ofhealthy men. Brain, behavior, and immunity. 2015;46:87-95. https://doi.org/10.1016/j.bbi.2014.12.024

  32. Fredericks CA, Drabant EM, Edge MD, Tillie JM, Hallmayer J, Ramel W, et al. Healthy young women with serotonintransporter SS polymorphism show a pro-inflammatory bias under resting and stress conditions.Brain, Behavior, and Immunity. 2010;24(3):350-357. https://doi.org/10.1016/j.bbi.2009.10.014

  33. Chandrashekara S, Jayashree K, Veeranna HB, Vadiraj HS, Ramesh MN, Shobha A, et al. Effects of anxietyon TNF-α levels during psychological stress. Journal of psychosomatic research. 2007;63:65-69.https://doi.org/10.1016/j.jpsychores.2007.03.001

  34. Lee JG. Diagnosis and management of acute cholangitis. Nature Reviews Gastroenterology and Hepatology.2009;6:533-541. https://doi.org/10.1038/nrgastro.2009.126

  35. von Känel R, Bellingrath S, Kudielka BM. Association between burnout and circulating levels of pro-andanti-inflammatory cytokines in schoolteachers. Journal of psychosomatic research. 2008;65(1):51-59.https://doi.org/10.1016/j.jpsychores.2008.02.007

  36. Aktas E, Sener E, Zengin O, Gocun PU, Deveci MA. Serum TNF-alpha levels: potential use to indicateosteoarthritis progression in a mechanically induced model. European Journal of Orthopaedic Surgery &Traumatology. 2012;22:119-22. https://doi.org/10.1007/s00590-011-0803-0

  37. Jordán AJ, Esteban Á, García M, Monmeneu JV, Espinosa D, Reyes F, et al. Prognostic value of serum levelsof tumor necrosis factor-alpha in patients with heart failure. Revista Española de Cardiología, 2003;56:160-7.https://doi.org/10.1016/s0300-8932(03)76840-7

  38. Wei S-T, Sun Y-H, Zong S-H, Xiang Y-B. Serum levels of IL-6 and TNF-α may correlate with activity andseverity of rheumatoid arthritis. Medical science monitor: international medical journal of experimental and clinicalresearch. International Scientific Information, Inc.; 2015;21:4030-4038. https://doi.org/10.12659/MSM.895116

  39. Carpenter LL, Gawuga CE, Tyrka AR, Lee JK, Anderson GM, Price LH. Association between plasma IL-6 responseto acute stress and early-life adversity in healthy adults. Neuropsychopharmacology. 2010;35:2617-2623. https://doi.org/10.1038/npp.2010.159

  40. Rohleder N, Aringer M, Boentert M. Role of interleukin-6 in stress, sleep, and fatigue. Annals of the New YorkAcademy of Sciences. 2012;1261:88-96. https://doi.org/10.1111/j.1749-6632.2012.06634.x




2020     |     www.medigraphic.com

Mi perfil

C?MO CITAR (Vancouver)

Arch Med. 2022;22