medigraphic.com
SPANISH

Ginecología y Obstetricia de México

Federación Mexicana de Ginecología y Obstetricia, A.C.
  • Contents
  • View Archive
  • Information
    • General Information        
    • Directory
  • Publish
    • Instructions for authors        
  • medigraphic.com
    • Home
    • Journals index            
    • Register / Login
  • Mi perfil

2023, Number 06

<< Back

Ginecol Obstet Mex 2023; 91 (06)

Partial hydatidiform mole with healthy live fetus reaching term

Porras-Ibarra GD, Santiago-Sanabria L, Martínez-Villafaña E, Porras-Zaragoza JL, Martínez-Olivares J
Full text How to cite this article

Language: Spanish
References: 23
Page: 462-467
PDF size: 347.85 Kb.


Key words:

Hydatidiform mole, High-risk pregnancy, Pregnancy complications.

ABSTRACT

Background: Partial molar pregnancy with coexisting healthy living fetus is a rare form of hydatidiform molas. Due to the few reported cases, there is a lack of guidelines for the medical care of these patients. Although the risk of obstetric complications in these cases is high, a large percentage of patients may go on to have a healthy newborn.
Clinical case: A 29-year-old primigravida patient with a spontaneous pregnancy. At 23.3 weeks, the placenta was detected by ultrasound to have multiple anechoic images in its interior, a "cluster of grapes" pattern suggesting a possible molar pregnancy. The patient decided to continue with the pregnancy after the obstetric risks were explained to her. During the remainder of the pregnancy she presented with gestational hypertension and thrombocytopenia, perhaps gestational. It was decided to terminate the pregnancy by abdominal approach at 38 weeks. The histopathological report corroborated the diagnosis of partial hydatidiform mole.
Conclusion: The timing of termination of pregnancy is determined based on maternal or fetal complications. Adequate communication with the patient is important.


REFERENCES

  1. Braga A, Obeica B, et al. A twin pregnancy with a hydatidiformmole and a coexisting live fetus. J Ultrason. 2017;17(71):229–305. doi: 10.15557/JoU.2017.0044

  2. Candelier Jean-Jacques. The hydatidiform mole.Cell Adh Migr. 2016;10(1–2):226–35. doi: 10.1080/19336918.2015.1093275.

  3. Rahamni M, Parviz S. A case report of partial molar pregnancyassociated with a normal appearing dizygotic fetus.Asian Pacific J Reprod. 2016;5(2):171–3. doi: 10.1016/j.apjr.2016.01.015

  4. McDonald T, Ruffolo E. Modern management of gestationaltrophoblastic disease. Obstet Gynecol Surv. 1983;38(2):67–83. doi: 10.1097/00006254-198302000-00001.

  5. Vejerslev L. Clinical management and diagnostic possibilitiesin hydatidiform mole with coexistent fetus. ObstetGynecol Surv. 1991;46(9):577–88. doi: 10.1097/00006254-199109000-00001

  6. Camacho A, Niño R. Partial molar pregnancy with live fetuscomplicated by intrauterine growth restriction and severepreeclampsia. Case reporta and review of the literature.Rev Colomb Obstet Ginecol. 2020;71(3):286–96. doi:10.18597/rcog.3461.

  7. Beischer N. Hydatidiform Mole with Coexistent Foetus. AustNZJ Obs Gynaec. 1966;6(2):127–41. doi: 10.1111/j.1479-828x.1966.tb00358.x.

  8. Villarreal C, Olvera L, et al. Mola with partial live fetus 20weeks pregnancy case report. Int J Fam Community Med.2020;4(2):44–6. doi: 10.15406/ijfcm.2020.04.00181

  9. Sánchez M, Ferri B, et al. Partial Mole with a Diploid Fetus:Case Study and Literature Review. Fetal Diagn Ther.2009;25:354–8. doi: 10.1159/000235885.

  10. Guvendag E, Ozturk N, et al. Partial molar pregnancyand coexisting fetus with diploid karyotype. J Maternfetal neonatal Med. 2007;20(2):175–81. doi:10.1080/14767050601134991.

  11. Kawasaki K, Kondoh E, et al. Live-born diploid fetus complicatedwith partial molar pregnancy presenting withpre-eclampsia, maternal anemia, and seemingly hugeplacenta: A rare case of confined placental mosaicism andliterature review. J Obstet Gynaecol Res. 2016;42(8):911–7.doi: 10.1111/jog.13025

  12. Hojberg K, Aagaard J, et al. Placental vascular malformationwith mesenchymal hyperplasia and a localized chorioangioma.A rarity simulating partial mole. Pathol Res Pr.1994;190(8):808–13. doi: 10.1016/S0344-0338(11)80429-2.

  13. Sarno A, Moorman A, et al. Partial molar pregnancy with fetalsurvival: an unusual example of confined placental mosaicism.Obs Gynecol. 1993;82(4):716–9. PMID: 8378025.

  14. Pollio F, Daniele F, et al. Hydatidiform mole with coexistentfetus. Cytogenetic features, diagnosis, and management.Minerva Ginecol. 2000;52(6):253–7. PMID: 11085049.

  15. Uemura N, Takai Y, et al. Molecular cytogenetic analysis of ahydatidiform mole with coexistent fetus: a case report. J MedCase Rep. 2019;13(256):1–5. doi: 10.1186/s13256-019-2180-y

  16. Petignat P, Billieux M, et al. Is genetic analysis useful in theroutine management of hydatidiform mole? Hum Reprod.2003;18(2):243–9. doi: 10.1093/humrep/deg091.

  17. Kumar S, Saikat M, et al. Expression of p57 immunomarkerin the classification and differential diagnosis ofpartial and complete hydatidiform moles. J Lab Physicians.2019;11(3):270–4. doi: 10.4103/JLP.JLP_130_19.

  18. Braga A, Mora P, et al. Challenges in the diagnosis andtreatment of gestational trophoblastic neoplasia worldwide.World J Clin Oncol. 2019;10(2):28–37. doi: 10.5306/wjco.v10.i2.28.

  19. Sebire N, Foskett M, et al. Outcome of twin pregnancieswith complete hydatidiform mole and healthy co-twin.Lancet. 2002;359(9324):2165–6. doi: 10.1016/S0140-6736(02)09085-2.

  20. Mangla M, Kaur H, et al. Partial mole with coexistentlive fetus: A systematic review of case reports. J Turk GerGynecol Assoc. 2022;23(2):83–94. doi: 10.4274/jtgga.galenos.2022.2021-9-11

  21. Gajewska M, Zygula A, et al. Twin pregnancy with a partialhydatidiform mole and a coexistent live fetus. Diagnosticand therapeutic dilemmas. A case report and the review ofliterature. Ginekol Pol. 2020;91(10):589–94. doi: 10.5603/GP.a2020.0109

  22. Gezahegn M. Singleton Partial Molar Pregnancy Deliveredin Third Trimester: A Case Report. J patiente care.2019;5(1):1-4. doi:10.35248/2573-4598.19.5.147

  23. Zeng C, Chen Y, et al. Partial hydatidiform mole and coexistentlive fetus: a case report and review of the literature.Open Med. 2019;14:843–6. doi: 10.1515/med-2019-0098




2020     |     www.medigraphic.com

Mi perfil

C?MO CITAR (Vancouver)

Ginecol Obstet Mex. 2023;91