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2021, Number 3

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Rev Cubana Plant Med 2021; 26 (3)

The protective effect of Descurainia sophia seed extract on oxidative stress and nephrotoxicity induced by acetaminophen in mice

Pourmahdi O, Gholami-Ahangaran M, Karimi-Dehkordi M, Ostadpoor M

Language: English
References: 39
Page:
PDF size: 199.59 Kb.


ABSTRACT

Introduction: Acetaminophen is the most common known agent which leads to hepatic and renal toxicity at an over dose in human and experimental animals.
Objective: The purpose of the current study was to investigate the protective effect of Descurainia Sophia seed extract on oxidative stress and nephrotoxicity induced by acetaminophen in mice.
Methods: In this study, 60 male albino mice were randomly assigned into six groups of ten mice, and DS seed extract was administered to mice for seven days in doses of (50,100,200 and 400 mg/kg) respectively. Toxicity was induced by acetaminophen (i.p. 500 mg/kg) for 7 days. 24 hours after the acetaminophen administration the mice were sacrificed under mild anesthesia and their blood was collected to estimate blood urea nitrogen (BUN), Creatinine, Uric acid and malondialdehyde (MDA) levels also, kidneys were removed for histopathological examination.
Results: Administration of acetaminophen significantly increased the BUN, creatinine, uric acid and MDA levels as compared to control group(p<0.05). DS seed extract pre-treatment significantly decreased serum BUN, Creatinine, Uric acid and MDA levels as compared to acetaminophen group (p<0.05). In histopathological examination DS extract restored the damage that cause by acetaminophen especially in dose of 400 mg/kg.
Conclusions: Our result demonstrate that the oral administration of DS seed extract has protective effect against acetaminophen nephropathy.


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