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2022, Number 283

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16 de abril 2022; 61 (283)

Structural proteins as the molecular basis of SARSCoV- 2 infection

Jiménez-Franco LE
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Language: Spanish
References: 10
Page: 1-2
PDF size: 324.49 Kb.


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The new coronavirus named SARS-CoV-2, which causes zoonotic COVID-19 disease, emerged in the city of China, Wuhan and spread worldwide with a record of alarming numbers. The World Health Organization declared it an international health emergency in January 2020 and despite countless efforts to contain its rapid spread, it was classified as a pandemic.
SARS-CoV-2 belongs to a diverse family of single-stranded positive-sense RNA viruses. In humans, four endemic coronaviruses (HCoV-229E, HCoV-OC43, HCoV-NL63 and HCoV-HKU1) are known to cause mild respiratory symptoms in most cases; a picture that is in contrast to the manifestations caused by the new strain, which is characterized by a febrile state, general symptoms, intense cough and dyspnea. Twenty-five percent of cases develop an acute respiratory syndrome due to pneumonia, leading to multiorgan failure.


REFERENCES

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  3. Serra Valdés MA. Infección respiratoriaaguda por COVID-19: unaamenaza evidente. Rev habancienc méd [Internet]. 2020 [citado28/02/2021]; 19(1):1-5. Disponibleen: http://www.revhabanera.sld.cu/index.php/rhab/article/view/3171

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  9. Andersen K, Rambaut A, LipkinI, Holmes E, Garry R. The proximalorigin of SARS-CoV-2. Nat Med [Internet].2020 [citado 28/02/2021];15(3):1-3. Disponible en: https://doi.org/10.1038/s41591-020-0820-9

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16 de abril. 2022;61