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2023, Number 6

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Med Int Mex 2023; 39 (6)

Uncommon dermal manifestations of malignant diseases

García FRLF, Chía VNG
Full text How to cite this article

Language: Spanish
References: 7
Page: 936--939
PDF size: 202.59 Kb.


Key words:

Bazex syndrome, Acrokeratosis, Neoplasms, Prostate specific antigen.

ABSTRACT

Background: Bazex paraneoplastic acrokeratosis (Bazex syndrome) is a rare paraneoplastic skin disease defined by scald, erythematous, violaceous plaques on the hands and feet or in other acral locations, such as the nose or ears. The syndrome is related to a variety of malignancies. Related neoplasms are predominantly oropharyngeal or gastrointestinal, but other malignancies have been reported. The diagnosis of Bazex syndrome should be considered in the presence of atypical psoriasiform lesions, since the diagnosis can substantially change the prognosis of patients.
Clinical case: An 86-year-old male patient who began his condition approximately two months ago with generalized itching and the appearance of a lesion on the back of the left foot, evaluated and treated by dermatology and angiology without improvement. Physical examination revealed macular lesions on the thoracic limbs and neck with scratching stigmata, with edema of the lower limbs ++ / +++, with evidence of venous insufficiency and a lesion on the dorsum of the left ankle in plaque shapes, raised, red and covered with scales accompanied by itching. Determination of prostate specific antigen done in 2019 was of 06.04 ng/mL.
Conclusions: Bazex syndrome is a rare dermatological paraneoplastic condition, which frequently, but not always, precedes the appearance of the malignant disease.


REFERENCES

  1. Räßler F, Goetze S, Elsne P. Acrokeratosis paraneoplastica(Bazex syndrome) a systematic review on risk factors,diagnosis, prognosis and management. JEADV 2017; 31(7): 1119-1136. DOI: 10.1111/jdv.14199.

  2. Rodrigues IA Jr, Gresta LT, Cruz RC, Gomes G, et al. Bazexsyndrome. An Bras Dermatología 2013; 88 (6 Suppl 1):209-211. doi: 10.1590/abd1806-4841.20132488.

  3. Iwanami K, Nakai M, Kitamura K. Bazex syndrome. InternMed 2018; 57: 1501-1502. doi: 10.2169/internalmedicine.9771-17.

  4. Shikino K, Ikusaka M. Bazex syndrome. CMAJ 2017; 189(17): E639. doi: 10.1503/cmaj.160912.

  5. Dabas G, De D, Handa S, Chatterjee D, Radotra BD. Acrokeratosisparaneoplastica (Bazex syndrome). QJM 2018; 111(1): 63-64. doi: 10.1093/qjmed/hcx187.

  6. Eckstein J, Healy E, Jain A, Hawkins D, et al. A series oftypical and atypical cases of Bazex syndrome: Identifyingthe red herring to avoid delaying cancer treatment. ClinCase Rep 2020; 8: 2259-2264. doi: 10.1002/ccr3.3133.

  7. Figueroa O, Espasandín M, García FJ, Fernández V, et al. Isit just a psoriasiform dermatitis? Dermatol Online J 2017;23 (11): 13030/qt77k9w4c0.




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Med Int Mex. 2023;39