García FRLF, Chía VNG, Severo HV, Monraz PS, Soto NG, Coronel AO, López OA

Language: Spanish
References: 3
Page: 940-947
PDF size: 302.24 Kb.

ABSTRACT

Background: Primary hyperparathyroidism is the most common cause of hypercalcemia and is most frequently identified in early postmenopausal women with hypercalcemia and abnormal parathyroid hormone concentrations.
Clinical case: A 62-year-old female patient who presented to the emergency room in a state of septic shock secondary to pyelonephritis due to extensive renal calcifications, antimicrobial and amine treatment was started, parathyroid hormone was requested, which was very high, and left nephrectomy was performed after exclusion by scintigraphy, with improvement but persistence of leukocytosis, procedures were performed for the study and treatment of pleural effusions, and a diagnosis of overlap syndrome was integrated with right ureterolithotripsy and later, parathyroidectomy.
Conclusions: There are no established treatment guidelines for overlap syndrome. High-risk patients suitable for intensive treatment should be considered for allogeneic transplantation.

REFERENCES

1. Silva BC, Cusano NE, Bilezikian JP. Primary hyperparathyroidism.Best Pract Res Clin Endocrinol Metab 2018. doi:10.1016/j.beem.2018.09.004.

2. Insogna K. Primary hyperparathyroidism. N Engl J Med2018; 379: 1050-9. doi: 10.1056/NEJMcp1714213.

3. Gonzalez J, Vijnovich Baron, Varela AI. Desafíos diagnósticosy terapéuticos en las neoplasias mieloproliferativas/mielodisplásicas: dudas y certezas clínicopatológicas.Hematologia 2019; 23 (Congreso Argentino de Hematología):221-229.