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Revista Cubana de Cardiología y Cirugía Cardiovascular

ISSN 1561-2937 (Print)
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2022, Number 1

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Rev Cubana Cardiol Cir Cardiovasc 2022; 28 (1)

Third-degree atrioventricular block associated with the use of timolol

Borges LJS, Castaño GRJ, Ayala HE, Rosas ME, Barón CJL, Cuevas CA
Full text How to cite this article

Language: Spanish
References: 6
Page: 1-4
PDF size: 303.32 Kb.


Key words:

atrioventricular block, pacemaker, glaucoma, timolol, brimonidine.

ABSTRACT

Topical beta-blockers for the treatment of glaucoma have greater absorption by the conjunctival vascular system than previously thought. These drugs avoid hepatic metabolism, and can cause adverse systemic effects such as conduction system disorders, which are more frequent in patients with cardiac disorders and the elderly. Therefore, when treating any patient with evidence of conduction disorders and a history of glaucoma, one should intentionally find out about the use of beta-blocking drugs such as thymol, since this is often not considered part of their treatment. This is the case of a 62-year-old patient who presented third-degree atrioventricular block, secondary to the chronic use of timolol in eye drops. Likewise, a review of the subject is made, in order to learn about the cardiovascular complications associated with this group of drugs, their diagnosis and treatment.


REFERENCES

  1. Hermida J, Bermejo A. Colirio de timolol como posible causa de un bloqueo aurículo-ventricular de tercer grado. Med Gen Fam [Internet]. 2012 [acceso 13/06/2021];1(5):240-43. Disponible en: http://mgyf.org/wp-content/uploads/2017/revistas_antes/V1N5/V1N5_240_243.pdf

  2. Wang Z, Denys I, Chen F, Cai L, Wang X, Kapusta DR, et al. Complete atrioventricular block due to timolol eye drops: a case report and literature review. BMC Pharmacol Toxicol [Internet]. 2019;20(1):73. Doi: https://doi.org/10.1186/s40360-019-0370-2

  3. Abbas SA, Hamadani SM, Ahmad U. Ophthalmic Timolol and Hospitalization for Symptomatic Bradycardia and Syncope: A Case Series. Cureus [Internet]. 2020;12(3):e7270. Doi: https://doi.org/10.7759/cureus.7270

  4. Rubín JM, Hevia S, Veganzones Bayón A, Barriales Á. Bloqueos atrioventriculares secundarios a betabloqueantes tópicos oftálmicos. Rev Esp Cardiol [Internet]. 1999 [acceso: 13/06/2021];52:532. Disponible en: https://www.revespcardiol.org/es-estudio-del-bloqueo-auriculoventricular-secundario-articulo-resumen-X0300893299001399?redirect=true

  5. Özcan KS, Güngör B, Osmonov D, Tekkeşin AI, Altay S, Ekmekçi A, et al. Management and outcome of topical beta-blocker-induced atrioventricular block. Cardiovasc J Afr [Internet]. 2015;26(6):210-3. Doi: https://doi.org/10.5830/CVJA-2015-030

  6. Sharifi M, Koch JM, Steele RJ, Adler D, Pompili VJ, Sopko J. Third degree AC block due to ophthalmic timilol solution. Intern J Cardiol [Internet]. 2021;80(2-3):257-9. Doi: https://doi.org/10.1016/s0167-5273(01)00489-2




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C?MO CITAR (Vancouver)

Rev Cubana Cardiol Cir Cardiovasc. 2022;28