Erge U, Arslan E, Büsra DE, Kaya O, Sapmaz MM, Gündüz O

Language: English
References: 25
Page: 199-207
PDF size: 367.50 Kb.

ABSTRACT

Aim: Acute kidney injury is an important public health problem worldwide due to the significant morbidities and the economic burden it causes. We aimed to investigate the effects of cannabinoid receptor agonists and antagonists on biochemical and histopathological parameters in myoglobinuric acute kidney injury (MAKI). Methods: Wistar rats were divided into seven groups. Six groups underwent a 50% glycerol injection to establish kidney injury, while one group received 200 physiological saline (PS) injection to serve as a control. Agonist (WIN55,212-2) and antagonist (AM251 or SR144528) injections were administered intraperitoneally at 60- and 75 minutes following glycerol injection. Serum and urine samples were collected, and kidney tissues were removed. Glutathione, malondialdehyde, urea, creatinine, and sodium levels were assayed. Histopathological evaluation was performed semi-quantitatively on the hematoxylin eosinstained sections. Results: Serum creatinine and urea levels were significantly higher in all kidney injury groups compared to control. Serum creatinine level was significantly lower in the WIN+SR144528 group compared to the AKI group. Histological damage score was significantly lower in the WIN and WIN+SR144528 groups compared to the AKI group. Conclusions: Blockade of cannabinoid 2 receptors improved kidney function and histology against MAKI, while blockade of cannabinoid 1 receptors caused negative results.

REFERENCES

1. Abebe A, Kumela K, Belay M, Kebede B, Wobie Y.Mortality and predictors of acute kidney injury inadults: a hospital-based prospective observationalstudy. Sci Rep. 2021;11(1):15672.

2. Ostermann M, Cerdá J. The Burden of AcuteKidney Injury and Related Financial Issues. ContribNephrol. 2018;193:100-12.

3. Hoste EAJ, Kellum JA, Selby NM, ZarbockA, Palevsky PM, Bagshaw SM, et al. Globalepidemiology and outcomes of acute kidney injury.Nat Rev Nephrol. 2018;14(10):607-25.

4. Kolhe NV, Eldehni MT, Selby NM, McIntyre CW.The reimbursement and cost of acute kidney injury:a UK hospital perspective. Nephron Clin Pract.2014;126(1):51-6.

5. Basile DP, Anderson MD, Sutton TA. Pathophysiologyof acute kidney injury. Comprehensive Physiology.2012;2(2):1303-53.

6. Vanholder R, Sever MS, Erek E, Lameire N.Rhabdomyolysis. J Am Soc Nephrol. 2000;11(8):1553-61.

7. Kaya O., Aydogdu N., Tastekin E., Karadag Ch.,Gunduz O., Sut N. Effects of Losartan on GlycerolinducedMyoglobinuric Acute Renal Failure in Rats.Kafkas Univ Vet Fak Derg 2013; 19(2):253-258.

8. Zou S, Kumar U. Cannabinoid Receptors and theEndocannabinoid System: Signaling and Functionin the Central Nervous System. Int J Mol Sci.2018;19(3):833.

9. Aghazadeh Tabrizi M, Baraldi PG, Borea PA,Varani K. Medicinal Chemistry, Pharmacology, andPotential Therapeutic Benefits of Cannabinoid CB2Receptor Agonists. Chem Rev. 2016;116(2):519-560.

10. 10) Pressly JD, Mustafa SM, Adibi AH, Alghamdi S,Pandey P, Roy KK, et al. Selective Cannabinoid 2Receptor Stimulation Reduces Tubular EpithelialCell Damage after Renal Ischemia-ReperfusionInjury. J Pharmacol Exp Ther. 2018;364(2):287-99.

11. 11) Barutta F, Corbelli A, Mastrocola R, Gambino R,Di Marzo V, Pinach S, et al. Cannabinoid receptor1 blockade ameliorates albuminuria in experimentaldiabetic nephropathy. Diabetes. 2010;59(4):1046-54.

12. Feizi A, Jafari MR, Hamedivafa F, Tabrizian P,Djahanguiri B. The preventive effect of cannabinoidson reperfusion-induced ischemia of mouse kidney.Exp Toxicol Pathol. 2008;60(4-5):405-10.

13. Chua JT, Argueta DA, DiPatrizio NV, KovesdyCP, Vaziri ND, Kalantar-Zadeh K, et al.Endocannabinoid System and the Kidneys: FromRenal Physiology to Injury and Disease. CannabisCannabinoid Res. 2019;4(1):10-20.

14. Ellman GL. Tissue sulfhydryl groups. Arch BiochemBiophys. 1959;82(1):70-7.

15. Heyman SN, Rosen S, Fuchs S, Epstein FH, BrezisM. Myoglobinuric acute renal failure in the rat: a rolefor medullary hypoperfusion, hypoxia, and tubularobstruction. J Am Soc Nephrol. 1996;7(7):1066-74.

16. Al Asmari AK, Al Sadoon KT, Obaid AA,Yesunayagam D, Tariq M. Protective effect ofquinacrine against glycerol-induced acute kidneyinjury in rats. BMC Nephrol. 2017;18(1):41.

17. Li XH, Liu YQ, Gong DY, Hai KR, Ke BW, ZuoYX. The Critical Role of Cannabinoid Receptor 2 inURB602-Induced Protective Effects Against RenalIschemia-Reperfusion Injury in the Rat. Shock.2020;54(4):520-30.

18. Mukhopadhyay P, Pan H, Rajesh M, Bátkai S, PatelV, Harvey-White J, et al. CB1 cannabinoid receptorspromote oxidative/nitrosative stress, inflammation,and cell death in a murine nephropathy model. Br JPharmacol. 2010;160(3):657-68.

19. Mukhopadhyay P, Baggelaar M, Erdelyi K,Cao Z, Cinar R, Fezza F, et al. The novel, orallyavailable, and peripherally restricted selectivecannabinoid CB2 receptor agonist LEI-101 preventscisplatin-induced nephrotoxicity. Br J Pharmacol.

20. 2016;173(3):446-58.20) Heyman SN, Lieberthal W, Rogiers P, BonventreJV. Animal models of acute tubular necrosis. CurrOpin Crit Care. 2002;8(6):526-34.

21. Tam J. The emerging role of the endocannabinoidsystem in the pathogenesis and treatment ofkidney diseases. J Basic Clin Physiol Pharmacol.2016;27(3):267-76.

22. Ritter JK, Li G, Xia M, Boini K. Anandamide andits metabolites: what are their roles in the kidney?Front Biosci (Schol Ed). 2016;8(2):264-77.

23. Gallelli CA, Calcagnini S, Romano A, KoczwaraJB, de Ceglia M, Dante D, et al. Modulation ofthe Oxidative Stress and Lipid Peroxidation byEndocannabinoids and Their Lipid Analogues.Antioxidants (Basel). 2018;7(7).

24. Zhou L, Zhou S, Yang P, Tian Y, Feng Z, Xie XQ,et al. Targeted inhibition of the type 2 cannabinoidreceptor is a novel approach to reduce renal fibrosis.Kidney Int. 2018;94(4):756-72.

25. Mukhopadhyay P, Rajesh M, Pan H, Patel V,Mukhopadhyay B, Bátkai S, et al. Cannabinoid-2receptor limits inflammation, oxidative/nitrosativestress, and cell death in nephropathy. Free Radic BiolMed. 2010;48(3):457-67.