medigraphic.com
SPANISH

Revista Biomédica

Centro de Investigaciones Regionales Dr. Hideyo Noguchi, Universidad Autónoma de Yucatán
  • Contents
  • View Archive
  • Information
    • General Information        
    • Directory
  • Publish
    • Instructions for authors        
  • medigraphic.com
    • Home
    • Journals index            
    • Register / Login
  • Mi perfil

2024, Number 1

<< Back Next >>

Rev Biomed 2024; 35 (1)

Effects of cinnamon and ginger on supraclavicular skin temperature and health parameters in young men

García-Torres E, Reyes-Meza V, Pérez-Flores GA
Full text How to cite this article

Language: English
References: 39
Page: 28-35
PDF size: 486.14 Kb.


Key words:

Cinnamon, ginger, thermogenic spices.

ABSTRACT

Introduction. Brown adipose tissue in humans is located in different areas of the body, mainly in the supraclavicular area and its activation with different thermogenic molecules could be reflected in this site. Active brown adipose tissue could be a strategy against obesity considering its participation in energy balance.
Objective. To evaluate the effect of cinnamon and ginger on supraclavicular skin temperature and health parameters in young men.
Material and methods. An experimental study was carried out among 36 young men who were assigned to one of three treatment groups: ginger drink, cinnamon drink, and potable water as a placebo group. The supraclavicular skin temperature, blood pressure, heart rate, glucose level, and triglycerides were recorded before and after ingesting the drink.
Results. An increase in supraclavicular skin temperature was observed after the ingestion of the cinnamon (0.62 °C), ginger (0.54 °C), and placebo (0.64 °C) drinks. In the group that ingested ginger, there was also a decrease in glucose (6.3 %), an increase in triglycerides (34.4 %), and a decrease in heart rate (13.3 %), but not significant in the cinnamon group or the placebo group.
Conclusion. Our results suggest that cinnamon and ginger both have thermogenic effects on the supraclavicular area in young men adults.


REFERENCES

  1. Astrup A, Breumand L, Toubro S. Pharmacologicaland clinical studies of ephedrine and other thermogenicagonists. Obes Res. 1995 Nov; 3:537–540.doi:10.1002/j.1550-8528.1995.tb00224.x

  2. Robinson L, Ojha S, Symonds ME, Budge H. Body massindex as a determinant of brown adipose tissue functionin healthy children. J Pediatr. 2014 Feb; 164: 318–322.doi:10.1016/j.jpeds.2013.10.005

  3. Sánchez-Delgado G, Martinez-Tellez B, Olza J, AguileraCM, Gil A, Ruiz JR. Role of exercise in the activationof brown adipose tissue. Ann Nutr Metab. 2015 Jul; 67:21–32. doi:10.1159/000437173

  4. Kajimura S, Spiegelman BM, Seale P. Brown andbeige fat: physiological roles beyond heat generation.Cell Metab. 2015 Oct; 22(4): 546-59. doi:10.1016/j.cmet.2015.09.007

  5. Chondronikola M, Sidossis LS. Brown and beige fat:from molecules to physiology. BBA - Molecular andCell Biology of Lipids. 2019 Jan; 1864(1): 91-103.doi:10.1016/j.bbalip.2018.05.014

  6. Cypess AM, Weiner LS, Roberts-Toler C, Elía EF,Kessler SH, Kahn PA, et al. Activation of human brownadipose tissue by a β3-adrenergic receptor agonist.Cell Metab. 2015 Jan; 21(1): 33–38. doi: 10.1016/j.cmet.2014.12.009

  7. Westerterp-Plantenga M, Diepvens K, Joosen AM,Bérubé-Parent S, Tremblay A. Metabolic effects ofspices, teas, and caffeine. Physiol Behav. 2006 Aug; 89:

  8. 85–91. doi:10.1016/j.physbeh.2006.01.0278. Tinsley GM, Urbina S, Mullins J, Outlaw J, HaywardS, Stone M, et al. Influence of a thermogenic dietarysupplement on safety markers, body composition,energy expenditure, muscular performance and hormoneconcentrations: a randomized, placebo-controlled,double-blind trial. J Sports Sci Med. 2017 Dec; 16: 459–467.

  9. Saito M, Yoneshiro T, Matsushita M. Activation andrecruitment of brown adipose tissue by cold exposure andfood ingredients in humans. Best Practice & ResearchClinical Endocrinology & Metabolism. 2016 Aug; 30:537e547. doi:10.1016/j.beem.2016.08.003

  10. Vogel RM, Joy JM, Falcone PH, Mosman MM, Kim MP,Moon JR. Consuming a multi-ingredient thermogenicsupplement for 28 days is apparently safe in healthyadults. Food Nutr Res. 2015 Jul; 59: 27999. doi:10.3402/fnr.v59.27999

  11. Stohs SJ, Badmaev V. A review of natural stimulant andnon-stimulant thermogenic agents. Phytother Res. 2016Feb; 30: 732–740. doi:10.1002/ptr.5583

  12. Ebrahimzadeh Attari V, Malek Mahdavi A, Javadivala Z,Mahluji S, Zununi Vahed S, Ostadrahimi A. A systematicreview of the anti-obesity and weight lowering effect ofginger (Zingiber officinale Roscoe) and its mechanismsof action. Phytother Res. 2018 Nov; 32: 577–585.doi:10.1002/ptr.5986

  13. Mansour MS, Ni YM, Roberts AL, Kelleman M, RoyChoudhury A, St-Onge MP. Ginger consumptionenhances the thermic effect of food and promotesfeelings of satiety without affecting metabolic andhormonal parameters in overweight men: A pilot study.Metabolism. 2012 Oct; 61: 1347–1352. doi:10.1016/j.metabol.2012.03.016

  14. Fujisawa F, Nadamoto T, Fushiki T. Effect of intake ofginger on peripheral body temperature. J Jpn Soc NutrFood Sci. 2005; 58: 3–9.

  15. Mozaffari-Khosravi H, Talaei B, Jalali BA, NajarzadehA, Mozayan MR. The effect of ginger powdersupplementation on insulin resistance and glycemicindices in patients with type 2 diabetes: A randomized,double-blind, placebo-controlled trial. ComplementTher Med. 2014 Feb; 22: 9–16. doi:10.1016/j.ctim.2013.12.017

  16. Attari VE, Ostadrahimi A, Jafarabadi MA, MehralizadehS, Mahluji S. Changes of serum adipocytokines and bodyweight following Zingiber officinale supplementation inobese women: a RCT. Eur J Nutr. 2016 Aug; 55: 2129–2136. doi.org/10.1007/s00394-015-1027-6

  17. Sheng X, Zhang Y, Gong Z, Huang C, Zang YQ.Improved insulin resistance and lipid metabolism bycinnamon extract through activation of peroxisomeproliferator-activated receptors. PPAR Res. 2008 Nov;2008: 581348–9. doi:10.1155/2008/581348

  18. Ranasinghe P, Jayawardena R, Pigera S, WathurapathaWS, Weeratunga HD, Premakumara GAS, et al.Evaluation of pharmacodynamic properties and safety ofCinnamomum zeylanicum (Ceylon cinnamon) in healthyadults: a phase I clinical trial. BBC Complement AlternMed. 2017 Dec; 17: 550. doi:10.1186/s12906-017-2067-7

  19. Shen Y, Honma N, Kobayashi K, Jia LN, Hosono T,Shindo K, et al. Cinnamon extract enhances glucoseuptake in 3T3-L1 adipocytes and C2C12 myocytes byinducing LKB1-AMP-activated protein kinase signaling.PLoS One. 2014 Feb; 9: e87894. doi:10.1371/journal.pone.0087894

  20. Kwan HY, Wu J, Su T, Chao XJ, Liu B, Fu X, et al.Cinnamon induces browning in subcutaneous adipocytes.Sci Rep. 2017 May; 7: 2447. doi:10.1038/s41598-017-02263-5

  21. Borzoei A, Rafraf M, Asghari-Jafarabadi M. Cinnamonimproves metabolic factors without detectable effects onadiponectin in women with polycystic ovary síndrome.Asia Pac J Clin Nutr. 2018 May; 27(3): 556-563.doi:10.6133/apjcn.062017.13

  22. Solomon TP, Blannin AK. Effects of short-term cinnamoningestion on in vivo glucose tolerance. Diabetes ObesMetab. 2007 Feb; 9: 895–901. doi:10.1111/j.1463-1326.2006.00694.x

  23. Wang JG, Anderson RA, Graham GM, Chu MC, SauerMV, Guarnaccia MM, et al. The effect of cinnamonextract on insulin resistance parameters in polycysticovary syndrome: a pilot study. Fertil Steril. 2007 Jul; 88:

  24. 240–243. doi:10.1016/j.fertnstert.2006.11.08224. Khan A, Safdar M, Khan MMA, Khattak KN, AndersonRA. Cinnamon improves glucose and lipids of peoplewith type 2 diabetes. Diabetes Care. 2003 Dec; 26:3215–8. doi:10.2337/diacare.26.12.3215

  25. Ziegenfuss TN, Hofheins JE, Mendel RW, Landis J,Anderson RA. Effects of a water-soluble cinnamonextract on body composition and features of the metabolicsyndrome in pre-diabetic men and women. J Int SocSports Nutr. 2006 May; 3: 45–53. doi.org/10.1186/1550-2783-3-2-45

  26. Hasanein MA, Gawad SHA, El-Megeid AAA. Effectof water extract prepared from green tea, black tea andcinnamon on obese rats suffering from diabetes. WorldAppl Sci J. 2012; 20: 976–987. doi: 10.5829/idosi.wasj.2012.20.07.2834

  27. van Marken Lichtenbelt WD, Vanhommerig JW,Smulders NM, Drossaerts JM, Kemerink GJ, BouvyND, et al. Cold-activated brown adipose tissue in healthymen. N Engl J Med. 2009 Apr 9;360(15):1500-8. doi:10.1056/NEJMoa0808718

  28. Saito M, Matsushita M, Yoneshiro T, Okamatsu-OguraY. Brown adipose tissue, diet-induced thermogenesis,and thermogenic food ingredients: from mice to men.Front Endocrinol. 2020 Apr 21;11:222. doi:10.3389/fendo.2020.00222

  29. SaitoM, Yoneshiro T. Capsinoids and related foodingredients activating brown fat thermogenesis andreducing body fat in humans. Curr Opin Lipidol. 2013 Feb1;24(1):71–77. doi:10.1097/MOL.0b013e32835a4f40

  30. Iwasaki Y, Tanabe M, Kobata K, Watanabe T. TRPA1agonists--allyl isothiocyanate and cinnamaldehyde--induce adrenaline secretion. Biosci Biotechnol Biochem.2008 Jun; 72: 2608–2614. doi:10.1271/bbb.80289

  31. Camacho S, Michlig S, de Senarclens-Bezençon C,Meylan J, Meystre J, Pezzoli M, et al. Anti-obesityand anti-hyperglycemic effects of cinnamaldehyde viaaltered ghrelin secretion and functional impact on foodintake and gastric emptying. Sci Rep. 2015 Jan; 21:7919. doi:10.1038/srep07919

  32. Iwasaki Y, Morita A, Iwasawa T, Kobata K, Sekiwa Y,Morimitsu Y, et al. A nonpungent component of steamedginger--[10]-shogaol--increases adrenaline secretion viathe activation of TRPV1. Nutr Neurosci. 2006 Aug; 9:169–78. doi:10.1080/110284150600955164

  33. Miyamoto M, Matsuzaki K, Katakura M, Hara T, TanabeY, Shido O. Oral intake of encapsulated dried ginger rootpowder hardly affects human thermoregulatory function,but appears to facilitate fat utilization. Int J Biometeorol.2015 Jan; 59: 1461–1474. doi:10.1007/s00484-015-0957-2

  34. Sugimoto K, Takeuchi H, Nakagawa K, MatsuokaY. Hyperthermic effect of ginger (Zingiberofficinale) extract-containing beverage on peripheralskin surface temperature in women. Evid BasedComplement Alternat Med. 2018 Oct; 2018: 3207623.doi:10.1155/2018/3207623

  35. Bartelt A, Bruns OT, Reimer R, Hohenberg H, IttrichH, Peldschus K, Kaul MG, Tromsdorf UI, Weller H,Waurisch C, Eychmüller A. Brown adipose tissueactivity controls triglyceride clearance. Nat Med. 2011Feb;17(2):200-5. doi:10.1038/nm.2297

  36. Nedergaard J, Bengtsson T, Cannon B. New powersof brown fat: fighting the metabolic syndrome. CellMetab. 2011 Mar 2;13(3):238-40. doi:10.1016/j.cmet.2011.02.009

  37. Brandão BB, Poojari A, Rabiee A. Thermogenic fat:development, physiological function, and therapeuticpotential. Int J Mol Sci. 2021 May 31;22(11):5906.doi:10.3390/ijms22115906

  38. Anderson RA, Zhan Z, Luo R, Guo X, Guo Q, ZhouJ, et al. Cinnamon extract lowers glucose, insulin andcholesterol in people with elevated serum glucose.J Tradit Complement Med. 2016 Oct; 6: 332–336.doi:10.1016/j.jtcme.2015.03.005

  39. Cannon B, Nedergaard J. Metabolic consequences ofthe presence or absence of the thermogenic capacity ofbrown adipose tissue in mice (and probably in humans).Int J Obesity. 2010 Oct; 34: S7–S16. doi:10.1038/ijo.2010.177




2020     |     www.medigraphic.com

Mi perfil

C?MO CITAR (Vancouver)

Rev Biomed. 2024;35