Sánchez GAA, Avila PMD, Bravo VJ, Gómez PMG

Language: Spanish
References: 2
Page: 65-68
PDF size: 259.52 Kb.

ABSTRACT

Myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD) is a rare, recently described disorder that covers a broad spectrum of manifestations and is defined by the presence of myelin oligodendrocyte glycoprotein (MOG) seropositivity that occurs mainly in children and young adults, which constitutes an entity within the spectrum of inflammatory diseases. In a proportion of patients, there may be an overlap in some of the clinical and radiological manifestations between MOGAD, multiple sclerosis (MS) and other demyelinating diseases. It affects the entire nervous system with a predilection for the optic nerve and spinal cord, with manifestations such as optic neuritis, transverse myelitis and acute disseminated encephalomyelitis, among others. The presence of specific clinical and paraclinical characteristics of this entity are of great help in early diagnosis, confirmed with the detection of anti-MOG antibodies in a cell-based assay, and allow to establish an adequate treatment as soon as possible with prognostic implication of the disease. We present a case of a young male with representative symptoms, the most relevant radiological findings, a discussion and review of the current literature.

REFERENCES

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2. Ambrosius W, Michalak S, Kozubski W, Kalinowska A. Myelin oligodendrocyte glycoprotein antibody-associated disease: current insights into the disease pathophysiology, diagnosis and management. Int J Mol Sci. 2020; 22 (1): 100. doi: 10.3390/ijms22010100.