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Cirugía Cardiaca en México

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Diario Oficial de la Sociedad Mexicana de Cirugía Cardiaca, A.C., y del Colegio Mexicano de Cirugía Cardiovascular y Torácica, A.C.
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2023, Number 3

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Cir Card Mex 2023; 8 (3)

Risk factors for low cardiac output syndrome after congenital heart surgery

Loredo-Medina J, Celis-Jasso JS, Saldaña-Becerra MA, Castro-Roblina LE
Full text How to cite this article

Language: English
References: 28
Page: 64-69
PDF size: 126.60 Kb.


Key words:

Cardiac surgery, Congenital heart disease, Low cardiac output syndrome.

ABSTRACT

Background. Congenital Heart Disease (CHD) is the most frequent malformation at birth. Although Mexico does not have accurate statistics, the prevalence is estimated at 8 per 1,000 live births. Additionally, 5 to 20% of the patients will present heart failure, increasing even more after a surgical procedure. Objective. Identify risk factors for heart failure after congenital heart disease surgery in which Del Nido cardioplegia was used. Material. Longitudinal and observational study. Patients admitted to the intensive pediatric cardiovascular unit after cardiac surgery from January to August 2021 were included. Low cardiac output syndrome was diagnosed by clinical, echocardiographic and blood gas parameters. Results. Sixty-nine patients were included; the median age was 9 months, 60.9% were male, and the most frequent surgical risk was RACHS 2 and 3 (50.8 and 27%, respectively); 92% of the patient had biventricular physiology. The most frequent diagnoses were ventricular septal defect (VSD) (30.4%) and Tetralogy of Fallot (TOF) (13%). Cardiopulmonary bypass (CPB) and aortic cross-clamping times were 111.58 minutes ± 53.74 minutes and 64.87 minutes ± 34.99 minutes, respectively. The identify risk factors were preoperative characteristics, age, weight, and height (p ‹0.05); intraoperative risk factors, CBP, aortic cross-clamping, selective cerebral perfusion, minimum temperature, and maximum lactate (p‹ 0.05); postoperative factor, arrhythmias (OR 13.6; 95%CI 3.741 - 49.801; p=0.000). Low cardiac output syndrome (LCOS) increased mortality (OR 2.3; 95%CI 1.270 - 2.304; p=0.005). Conclusions. LCOS was present in 49.3% of the patients with a 2.3- fold increase in mortality. We identified several risk factors and documented a 14.3% mortality rate.


REFERENCES

  1. Calderón-Colmenero J, Cervates-Salazar JL, Curi-Curi PJ, Ramírez-MarroquínS. Problemática de las cardiopatías congénitas en México. Propuestade regionalización. Arch Cardiol Mex. 2010;80(2):133–140. DOI: S1405-99402010000200012.

  2. Pérez-Navero JL, de la Torre-Aguilar MJ, Ibarra de la Rosa I, et al. Cardiac Biomarkersof Low Cardiac Output Syndrome in the Postoperative Period After CongenitalHeart Disease Surgery in Children. Rev Esp Cardiol (English Edition).2017;70(4):267–274. DOI: 10.1016/j.rec.2016.09.011.

  3. Du X, Chen H, Song X, et al. Risk factors for low cardiac output syndrome in childrenwith congenital heart disease undergoing cardiac surgery: A retrospective cohortstudy. BMC Pediatrics. 2020;20(1):1–10. DOI: 10.1186/s12887-020-1972-y.

  4. Baño-Rodrigo A, Domínguez-Pérez F, Fernández-Pineda L, Gómez-GonzálezR. Guías de práctica clínica de la Sociedad Española de Cardiología en el postoperadode cardiopatía congénita. Rev Esp Cardiol. 2000;53:1496–526. DOI:X0300893200120813.

  5. Cassalett-Bustillo G. Falla cardíaca en pacientes pediátricos. Fisiopatología ymanejo. Parte I. Rev Colomb Cardiol. 2018;25(4) 286–294. DOI: 10.1016/j.rccar.2018.02.003.

  6. Chambers DJ, Fallouh HB. Cardioplegia and cardiac surgery: Pharmacologicalarrest and cardioprotection during global ischemia and reperfusion. Pharmacologyand Therapeutics 127. 2010: 41–52. DOI: 10.1016/j.pharmthera.2010.04.001.

  7. Buckberg GD, Athanasuleas CL. Cardioplegia: Solutions or strategies?. Eu J CardiothoracSurg. 2016; 50:787–91. DOI: 10.1093/ejcts/ezw228.

  8. Suleiman MS, Hancock M, Shukla R, Rajakaruna C, Angelini GD. Cardioplegicstrategies to protect the hypertrophic heart during cardiac surgery. Perfusion.2011; 26: 48–56. DOI: 10.1177/0267659111420607.

  9. Doenst T, Schlensak C, Beyersdorf F. Cardioplegia in pediatric cardiac surgery:Do we believe in magic? Ann Thorac Surg. 2003; 75(5): 1668 - 77. DOI: 10.1016/S0003-4975(02)04829-4.

  10. Drury NE, Yim I, Patel AJ, et al. Cardioplegia in paediatric cardiac surgery: A systematicreview of randomized controlled trials. Interac CardioVasc Thorac Surg.2019; 28:144–50. DOI: 10.1093/icvts/ivy199.

  11. Kotani Y, Tweddell J, Gruber P, et al. Current cardioplegia practice in pediatriccardiac surgery: A North American multiinstitutional survey. Ann Thorac Surg.2013;96:923–9. DOI: 10.1016/j.athoracsur.2013.05.052.

  12. Jonas RA, DiNardo J, Laussen PC, Howe R, LaPierre R, Matte G. ComprehensiveSurgical Management of Congenital Heart Disease. 2nd ed. New York: Taylor &Francis Group; 2014; Chapter 11: 207-218.

  13. Ginther RM, Gorney R, Forbess JM. Use of del Nido Cardioplegia Solution anda Low-Prime Recirculating Cardioplegia Circuit in Pediatrics. JECT. 2013; 45:46–50. DOI: PMC4557463.

  14. Matte GS, del Nido PJ. History and use of del Nido Cardioplegia Solution atBoston Children’s Hospital. J Extra Corpor Technol. 2012; 44: 98–103. DOI:PMC4557532.

  15. Sanetra K, Pawlak I, Cisowski M. Del Nido Cardioplegia – What is the currentevidence? Kardiochirugia i Torakochirugia Polska. 2018; 15 (2): 114-118. DOI:10.5114/kitp.2018.76477.

  16. Jenkins KJ et all. Consensus-based method for risk adjustment for surgery for congenitalheart disease. J Thorac Cardiovasc Surg. 2002; 123: 110-8. DOI: 10.1067/mtc.2002.119064.

  17. Song B, Dang H, Dong R. Analysis of risk factors of low cardiac output syndromeafter congenital heart disease operation: what can we do. J Cardiothorac Surg.2021; 135(16): 1-6. DOI: 10.1186/s13019-021-01518-7.

  18. Sinha P, Zurakowski D, Jonas RA. Comparison of Two Cardioplegia SolutionsUsing Thermodilution Cardiac Output in Neonates and Infants. Ann Thorac Surg2008; 86: 1613-9. DOI: 10.1016/j.athoracsur.2008.07.031.

  19. Lomivorotov VV, Efremov SM, Kirov MY, Fominskiy EV, Karaskov AM.Low-Cardiac-Output Syndrome After Cardiac Surgery. J Cardiothorac VascAnesth. 2017;31(1):291-308. doi: 10.1053/j.jvca.2016.05.029.

  20. Cui Y, Qu J, Liang H, Li Z. Relationship between perioperative N-terminal probrainnatriuretic peptide and maximum inotropic score in children after cardiacsurgery. J Thorac Cardiovasc Surg. 2018;155(6):2619-2621. doi: 10.1016/j.jtcvs.2018.02.074.

  21. Qu J, Liang H, Zhou N, Li L, Wang Y, Li J, Cui Y. Perioperative NT-proBNPlevel: Potential prognostic markers in children undergoing congenital heart diseasesurgery. J Thorac Cardiovasc Surg. 2017;154(2):631-640. doi: 10.1016/j.jtcvs.2016.12.056.

  22. Butts RJ, Scheurer MA, Atz AM, Zyblewski SC. Comparison of Maximum VasoactiveInotropic Score and Low Cardiac Output Syndrome as Markers of EarlyPostoperative Outcomes After Neonatal Cardiac Surgery. Padiatr Cardiol. 2012;33(4): 633-638. DOI: 10.1007/s00246-012-0193-z.

  23. Davidson J, Tong S, Hancock H, Hauck A, da Cruz E, Kaufman J. Prospectivevalidation of the vasoactive-inotropic score and correlation to short-term outcomesin neonates and infants after cardiothoracic surgery. Intensive Care Med.2012;38(7):1184-90. doi: 10.1007/s00134-012-2544-x.

  24. Froese NR, Sett SS, Mock T, Krahn GE. Does troponin-I measurement predict lowcardiac output syndrome following cardiac surgery in children? Crit Care Resusc.2009; 11:116-121. DOI: 10.3316/INFORMIT.513680419450212.

  25. Pawlak J. Clinical Impact of Del Nido versus Custodiol HTK Cardioplegia Solutionsin the Postoperative Period in Pediatric Cardiac Surgery Patients. Thesisat Faculty of the Milwaukee School of Engineering. 2018: 22-28. Available at:https://milwaukee.ent.sirsi.net/client/en_US/search/asset/1481. Last Access: 27December, 2022.

  26. Lacour-Gayet F, Clarke D, Jacobs J, et al; Aristotle Committee. The Aristotlescore: a complexity-adjusted method to evaluate surgical results. Eur J CardiothoracSurg. 2004;25(6):911-24. doi: 10.1016/j.ejcts.2004.03.027.

  27. Maganti M, Badiwala M, Sheikh A, et al. Predictors of low cardiac output syndromeafter isolated mitral valve surgery. J Thorac Cardiovasc Surg. 2010;140(4):790-6.doi: 10.1016/j.jtcvs.2009.11.022.

  28. Yuerek M, Rossano JW, Mascio CE, Shaddy RE. Postoperative management ofheart failure in pediatric patients. Expert Rev Cardiovasc Ther. 2016;14(2):201-15. doi: 10.1586/14779072.2016.1117388.




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Cir Card Mex. 2023;8