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2024, Number 2

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Sal Jal 2024; 11 (2)

Berger disease in an adolescent. The importance of urinary microscopy. Report of a clinical case

Trujillo-Sánchez AU, Vega-Ramírez JR, Del CAP, Lara-López A, Rosas-Trujillo LB, García-Castañeda FA, Del CMA
Full text How to cite this article 10.35366/115692

DOI

DOI: 10.35366/115692
URL: https://dx.doi.org/10.35366/115692

Language: Spanish
References: 10
Page: 108-111
PDF size: 219.06 Kb.


Key words:

Berger´s disease, hematuria, urinary sediment, nephrolithiasis, glomerulonephritis, dysmorphic erythrocytes.

ABSTRACT

We present the clinical case of a 17-year-old patient diagnosed with nephrolithiasis and Berger's disease, confirmed by UroTac and renal biopsy, respectively. Berger's disease, also known as IgA nephropathy, is the most common glomerulonephritis and is characterized by the deposition of immunoglobulin A in the renal glomerulus, which can lead to chronic renal failure. The patient presented with proteinuria and hematuria, both macroscopic and microscopic, which was confirmed by the analysis of urinary sediment where dysmorphic erythrocytes were found. The publication of this clinical case is of great importance, as the diagnosis can be challenging. This is especially true in Mexico, where access to certain studies such as renal biopsy may be limited, making this study an economical and accessible tool to guide diagnosis and early detection of any renal disorder.


REFERENCES

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  2. Shin DH, Lim BJ, Han IM, Han SG, Kwon YE, Park KS, et al. Glomerular IgG deposition predicts renal outcome in patients with IgA nephropathy. Mod Pathol. 2016;29(7):743-752.

  3. Bellur SS, Troyanov S, Cook HT, Roberts IS; Working Group of International IgA Nephropathy Network and Renal Pathology Society. Immunostaining findings in IgA nephropathy: correlation with histology and clinical outcome in the Oxford classification patient cohort. Nephrol Dial Transplant. 2011;26(8):2533-2536.

  4. Lv J, Shi S, Xu D, Zhang H, Troyanov S, Cattran DC, et al. Evaluation of the Oxford Classification of IgA nephropathy: a systematic review and meta-analysis. Am J Kidney Dis. 2013;62(5):891-899.

  5. Selewski DT, Ambruzs JM, Appel GB, et al. Clinical Characteristics and treatment patterns of children and adults with IgA nephropathy or IgA vasculitis: findings from the CureGN study. Kidney Int Rep. 2018 Aug 1;3(6): 1373-1385.

  6. Avgustin Rotar N, Jerman A, Skoberne A, Borstnar S, Kojc N, Lindic J. The predictive value of urinary erythrocyte morphology for proliferative glomerular kidney disease. Clin Nephrol. 2021 Suppl;96(1):49-55.

  7. Perazella MA. The urine sediment as a biomarker of kidney disease. Am J Kidney Dis. 2015;66(5):748-755.

  8. Yu GZ, Guo L, Dong JF, Shi SF, Liu LJ, Wang JW, et al. Persistent Hematuria and Kidney Disease Progression in IgA Nephropathy: A Cohort Study. Am J Kidney Dis. 2020;76(1):90-99.

  9. Saha MK, Massicotte-Azarniouch D, Reynolds ML, Mottl AK, Falk RJ, Jennette JC, et al. Glomerular hematuria and the utility of urine microscopy: a review. Am J Kidney Dis. 2022;80(3):383-392.

  10. Cavanaugh C, Perazella MA. Urine sediment examination in the diagnosis and management of kidney disease: core curriculum 2019. Am J Kidney Dis. 2019;73(2):258-272.




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Sal Jal. 2024;11