medigraphic.com
Organo Oficial de la Sociedad Mexicana de Urología

2024, Number 1

<< Back Next >>

Rev Mex Urol 2024; 84 (1)

Systematic review of Zinner syndrome

Palacios-Rosas E, Torres-Razo A, Enríquez-González EA

Language: Spanish
References: 40
Page: 1-10
PDF size: 251.76 Kb.


ABSTRACT

Zinner syndrome is characterized as a pathology of congenital origin in which there is a unilateral absence of the kidney, presence of cysts and obstruction in the ejaculatory ducts. Being diagnosed in the stage of sexual activity of patients, it can cause problems in the person’s sexuality or reproduction. The objective of this work was to carry out a systematic review of clinical cases reported in the literature between 2013 and 2023. 42 reports of clinical cases with Zinner syndrome were evaluated, with a total of 49 patients with a mean age of 22.5 years, the 77.55 % of the patients presented cysts, absence of the right kidney in 44.90 % of the patients, and 91.84 % presented pain. The most common treatment for this pathology was laparoscopy (16.33 %) and in the reviewed cases there were no complications or deaths. Identifying the different presentations of this syndrome could improve the speed of diagnosis and guarantee effective management, thereby improving the quality of life of patients.


REFERENCES

  1. Kumar S, G KI, Khalil-Khan A, Arul PitchaiADP, Sathiamoorthy R, Raju E. ZinnerSyndrome. Cureus. 2022 Nov 9;14(11):e31308.https://doi.org/10.7759/cureus.31308

  2. Abakar D, Badi FE, Sabiri M, El Manjra S,Lezar S, Essodegui F. Zinner Syndrome.European Journal of Case Reports in InternalMedicine. 2021; 8(7):002628. https://doi.org/10.12890/2021_002628

  3. Randhawa JS, Shankaran R, NagamahendranR, Upadhye MA, Deepak H. Zinner Syndromewith Papillary Neoplasm: A Rare Case Report.Journal of Indian Association of PediatricSurgeons. 2022 Jul-Aug;27(4):473-475. https://doi.org/10.4103/jiaps.jiaps_84_21

  4. Regmi AR, Mishra S, Gurung A, Acharya A,Paneru LD, Ghimire A. Zinner’s syndrome:A rare diagnosis of congenital seminal vesiclecyst and renal agenesis on basis of radiologicalimaging and its management. InternationalJournal of Surgery Case Reports. 2022Aug;97:107434. https://doi.org/10.1016/j.ijscr.2022.107434

  5. Gurung B, Panta OB, Dhakal V, GhimireRK. Zinner Syndrome: A Case Report ofRare Urogenital Anomaly. Journal of MedicalUltrasound. 2021 May 4;30(1):59-61. https://doi.org/10.4103/jmu.jmu_125_20

  6. Sada F, Cekaj E, Saraci B, Shazi O, Al-MadaniA, Jahanian S, et al. Challenging clinicalpresentation of Zinner syndrome. RadiologyCase Reports. 2023 Jan;18(1):256–9. https://doi.org/10.1016/j.radcr.2022.10.006

  7. Foladi N, Nasery MN. Right-sided Zinnersyndrome with a left side quadrupled ureter–a case report. Radiology Case Reports. 2021Oct;16(10):2873–7. https://doi.org/10.1016/j.radcr.2021.06.086

  8. Ostrowska M, Grześk M, Kaczyński S, SkwaraD, Kulik K, Kowalski F, Ostrowski A, Drewa T.Zinner Syndrome-A Rare Cause of RecurrentEpididymitis and Infertility. Clinics and Practice.2021 Dec 9;11(4):942-946. https://doi.org/10.3390/clinpract11040108

  9. Rahoui M, Ouanes Y, Chaker K, Bibi M, MradDali K, Sellami A, Ben Rhouma S, Nouira Y. Anunusual cause of painful ejaculation in a youngpatient: Zinner syndrome. Annals of Medicineand Surgery. 2022 Jun 10;79:103982. https://doi.org/10.1016/j.amsu.2022.103982

  10. Ansari FM, Para SA, Singh S, Wani MS,Bhat AH, Maurya MK. Zinner’s syndrome:Masquerading as pyonephrotic ectopic kidney.Radiology Case Reports. 2023 Jan;18(1):131–4.https://doi.org/10.1016/j.radcr.2022.09.060

  11. Canales-Casco N, Dominguez-Amillo A,Arrabal-Polo MA, Sanchez-Tamayo FJ, Arrabal-Martin M, Cozar-Olmo JM. Hematospermiaas a Rare Form of Presentation of ZinnerSyndrome. Urology. 2017 Jan;99:e15–6. https://doi.org/10.1016/j.urology.2016.09.030

  12. Beyene E, Tadele E, Negassa M. Zinnersyndrome: A first case report from Ethiopia.Radiology Case Reports. 2023 Jan;18(1):86–90.https://doi.org/10.1016/j.radcr.2022.09.074

  13. Almofareh AM, Aljuaid KM, Almirabi SA,Hakami YM, Alwan AM. Zinner Syndrome: ACase Report of a Rare Etiology of Infertility.Cureus. 2021 Aug 23;13(8). https://doi.org/10.7759/cureus.17386

  14. Kori R, Bains L, Lal P, Gupta S. Zinner syndromemimicking bladder outlet obstruction managedwith aspiration. Urology Annals. 2019 Oct-Dec;11(4):449-452. https://doi.org/10.4103/ua.ua_152_18

  15. Almuhanna AM, Alsuhaibani S, Almesned R,Almatar A, Alali H. Zinner’s syndrome: Casereport of a rare maldevelopment in the malegenitourinary tract. Urology Case Reports. 2021Nov;39:101839. https://doi.org/10.1016/j.eucr.2021.101839

  16. Maehana T, Fukuta F, Kobayashi K, Hirobe M,Tanaka T, Masumori N. Laparoscopic Surgeryfor Seminal Vesicle Cysts and Ureterocelewith Urination Disorder: A Case Report ofZinner Syndrome. Journal of Endourology CaseReports. 2018 May;4(1):35–8. https://doi.org/10.1089/cren.2018.0008

  17. Kwenda EP, Locke RA, Archer JS, Su LM,Shenoy A, DeMarco RT, et al. Robot-AssistedLaparoscopic Resection of the MesonephricDuct Remnant in a Patient with ZinnerSyndrome. Journal of Endourology CaseReports. 2020 Sep 1;6(3):198–201. https://doi.org/10.1089/cren.2020.0020

  18. Ibrahimi A, Hosni A, Ziani I, Laamrani FZ, ElSayegh H, Jroundi L, et al. Zinner’s Syndrome:A Rare Diagnosis of Dysuria Based on Imaging.Case Reports in Urology. 2020 Dec 7;2020:1–6.https://doi.org/10.1155/2020/8826664

  19. Florim S, Oliveira V, Rocha D. Zinner syndromepresenting with intermittent scrotal pain in ayoung man. Radiology Case Reports. 2018 Sep

  20. 20;13(6):1224-1227. https://doi.org/10.1016/j.radcr.2018.08.01220. Marzocchi G, D’Onofrio R, Branchini M,Lovato L. Unilateral scrotal discomfort in apatient with known renal agenesis: do not forgetabout Zinner syndrome. BMJ Case Reports. 2022Jan;15(1):e248468. https://doi.org/10.1136/bcr-2021-248468

  21. Shah S, Patel R, Sinha R, Harris M. Zinnersyndrome: an unusual cause of bladderoutflow obstruction. BJR Case Reports. 2017Jun;3(2):20160094. https://doi.org/10.1259/bjrcr.20160094

  22. Sundar R, Sundar G. Zinner syndrome: anuncommon cause of painful ejaculation.BMJ Case Reports. 2015 Mar 6;2015(mar061):bcr2014207618–8. https://doi.org/10.1136/bcr-2014-207618

  23. Khoda J, Sen S, Chatterjee A. Incidentaldetection of Zinner syndrome in a patient withnonseminomatous germ cell tumor of testis.Urology Annals. 2020 Oct-Dec;12(4):394-395.https://doi.org/10.4103/ua.ua_11_20.

  24. Smith JS, Springhart WP. Ejaculatory DuctObstruction in the Setting of an Ectopic Ureter.Sexual Medicine. 2020 May 18;8(3):574–6.https://doi.org/10.1016/j.esxm.2020.03.004

  25. Hergan B, Fellner FA, Akbari K. Incidentalimaging findings suggesting Zinner syndromein a young patient with pulmonary embolism:A case report. Radiology Case Reports. 2020Apr;15(4):437–41. https://doi.org/10.1016/j.radcr.2020.01.027

  26. Symeonidis EN, Gkekas C, Tsifountoudis I,Symeonidis A, Georgiadis C, Kalyvas V, etal. Incidental finding of Zinner syndrome in aGreek military recruit: a case report of a rareclinical entity. Military Medical Research. 2019Feb 14;6(1). https://doi.org/10.1186/s40779-019-0194-9

  27. Campora M, Olivero A, Toncini C, Spina B,Fulcheri E, Terrone C, et al. Zinner Syndrome:A Diagnostic Challenge. The Aid of Morphology,Embryology, and Immunohistochemistry.Urology. 2017 Oct;108:e3–5. https://doi.org/10.1016/j.urology.2017.06.013

  28. Cito G, Gemma L, Giachini C, Micelli E, CocciA, Fucci R, Picone R, Sforza S, Nesi G, SantiR, Minervini A, Masieri L, Carini M, CocciaME, Natali A. Sperm retrieval by conventionaltesticular sperm extraction for assistedreproduction in patients with Zinner syndrome.Clinical and Experimental ReproductiveMedicine. 2021 Mar;48(1):85-90. https://doi.org/10.5653/cerm.2020.03769

  29. Naval-Baudin P, Carreño García E, SanchezMarquez A, Valcárcel José J, Romero NM.Multicystic seminal vesicle with ipsilateralrenal agenesis: two cases of Zinner syndrome.Scandinavian Journal of Urology. 2016Dec;51(1):81–4. https://doi.org/10.1080/21681805.2016.1257650

  30. AlArifi M, Al-Gahwary M, Gomha M.The Association of Renal Agenesis andIpsilateral Seminal Vesicle Cyst: ZinnerSyndrome Case Report. Case Reports inUrology. 2019 Jun 23;2019:1–3. https://doi.org/10.1155/2019/1242149

  31. Mehra S, Ranjan R, Garga UC. Zinnersyndrome—a rare developmental anomaly ofthe mesonephric duct diagnosed on magneticresonance imaging. Radiology Case Reports. 2016Dec;11(4):313–7. https://doi.org/10.1016/j.radcr.2016.04.002

  32. Gorantla R, Allu S, Rao A. A Triad of UnilateralRenal Dysgenesis with Ipsilateral SeminalVesical and Ejaculatory Duct Obstruction: AnUncommon Urogenital Congenital Anomaly,Zinner Syndrome—A Case Report. Indian Journalof Radiology and Imaging. 2021 Jul;31(03):707–9. https://doi.org/10.1055/s-0041-1735503

  33. Kord E, Zisman A, Darawsha AE, Dally N,Noh PH, Neheman A. Minimally InvasiveApproach for Treatment of Seminal VesicleCyst Associated with Ipsilateral Renal Agenesis.Urologia Internationalis. 2017;99(3):338–42.https://doi.org/10.1159/000464298

  34. Farooqui A, AlDhahir L, Mahfooz AB. Massiveseminal vesicle cyst with ipsilateral renalagenesis - Zinner syndrome in a Saudi patient.Urology Annals. 2018 Jul-Sep;10(3):333-335.https://doi.org/10.4103/ua.ua_17_18

  35. Haddock P, Wagner JR. Seminal Vesicle CystWith Ipsilateral Renal Agenesis and EctopicUreter (Zinner Syndrome). Urology. 2015May;85(5): e41–2. https://doi.org/10.1016/j.urology.2015.02.015

  36. Cito G, Sforza S, Gemma L, Cocci A, Di MaidaF, Dabizzi S, et al. Infertility case presentationin Zinner syndrome: Can a long-lasting seminaltract obstruction cause secretory testicularinjury? Andrologia. 2019 Oct 7;51(11). https://doi.org/10.1111/and.13436

  37. Ghonge N, Aggarwal B, Sahu A. Zinnersyndrome: A unique triad of mesonephricduct abnormalities as an unusual cause ofurinary symptoms in late adolescence. IndianJournal of Urology. 2010;26(3):444. https://doi.org/10.4103/0970-1591.70592

  38. Khanduri S, Katyal G, Sharma H, GoyalA, Singh N, Yadav H. Unique Associationof Multiple Seminal Vesicle Cysts withContralateral Renal Agenesis: A Rare Variantof Zinner Syndrome. Cureus. 2017 Jul 1; 9(7).https://doi.org/10.7759%2Fcureus.1415

  39. Aghaways I, Ahmed SM. EndourologicIntervention for Management of Infertilityin a Man with Zinner Syndrome Resulting ina Natural Pregnancy. Journal of EndourologyCase Reports. 2016 Dec;2(1):71–3. https://doi.org/10.1089/cren.2016.0010

  40. Razdan S, Kryvenko ON, Razdan S. Roboticassistedlaparoscopic vesiculectomy in a patientwith atypical Zinner syndrome presenting withlarge cyst involving bilateral seminal vesiclesand vasa deferentia. Urology Case Reports. 2018May; 18:79–81. https://doi.org/10.1016/j.eucr.2018.03.014




2020     |     www.medigraphic.com