2024, Number 2
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Acta Pediatr Mex 2024; 45 (2)
Dress syndrome induced by minocycline in a 15-year-old patient. Clinical case
Izaguirre PJC, Alas PC, Rodríguez CEC, Mass CAG, Oliva CLM
Language: Spanish
References: 12
Page: 123-128
PDF size: 230.09 Kb.
ABSTRACT
Background: Drug Reaction Syndrome with Eosinophilia and Systemic Symptoms
(DRESS) is an adverse drug reaction, being life-threatening in 10% of cases.
Clinical case: 15-year-old male patient attended the pediatric emergency department
with a clinical history of morbilliform and pruritic exanthema on the face and neck
of 9 days of evolution, extending to the thorax and extremities, accompanied by fever
of 38.0°C of 1 day of evolution. The patient had a history of atopy and acne vulgaris,
treated with minocycline. On admission the hemogram showed leukocytes 16,900
cells/ml, eosinophils 18.2%, neutrophils 6.2%. Blood chemistry revealed: creatinine
1.92 mg/dl, TSGO 45 U/L, TSGP 287 U/L, CRP: 62.8 mg/L and ESR 21 mm/h. It was
decided to admit him to the pediatric intensive care unit, since he complies with 7
RegiSCAR points.
Conclusion: DRESS syndrome is a severe and potentially fatal reaction; its diagnosis
is a challenge due to its heterogeneity and clinical variability. It should be taken
into consideration after a detailed interrogation that yields the use of suspicious drugs
prior to the onset of symptoms, even though its incidence has not been fully described.
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