Rubio GAF, Guerrero GC, Narváez RJL, Narváez OIG, Montes HPA, Benitez MDR

Language: Spanish
References: 11
Page: 91-96
PDF size: 202.29 Kb.

ABSTRACT

Objective: To establish whether epicardial fat thickness correlates with pulse wave velocity in subjects with metabolic syndrome.
Materials and Methods: A clinical, observational, cross-sectional study done in patients with metabolic syndrome in whom epicardial fat thickness was measured by echocardiography. In all of them, pulse wave velocity was determined. The diagnosis of metabolic syndrome was made according to the criteria of the International Diabetes Federation.
Results: There were evaluated 33 patients with metabolic syndrome. Patients with an epicardial fat thickness ≥ 5 mm had a significantly higher pulse wave velocity than subjects with an epicardial fat thickness ≤ 5 mm (11.15 ± 1.15 vs 8.41 ± 1.2; p = 0.00012). A significant correlation (r = 0.727, r2 = 0.529, p = 0.0001) between adiponecepicardial fat thickness and PWV was found. When evaluating the risk of presenting a pulse wave velocity › 9.0 in patients with an epicardial fat thickness ≥ 5 mm, we found statistical significance (p = 0.0011). No patients with epicardial fat thickness ≥ 5 mm showed normal pulse wave velocity.
Conclusions: Epicardial fat thickness correlates significantly with pulse wave velocity in subjects with metabolic syndrome, suggesting a role for epicardial fat on the mechanisms that lead to arterial stiffness, and giving more information about its role in increasing cardiovascular risk in those patients.

REFERENCES

1. Baez-Duarte BG, Zamora-Ginez I, Rodríguez-Ramírez SO,Pesqueda-Cendejas LK, García-Aragón KH. TG/HDL index toidentify subjects with metabolic syndrome in the Mexicanpopulation. Índice TG/HDL para identificar a sujetos consíndrome metabólico en población mexicana. Gac MedMex 2022; 158 (5): 259-264. https://doi.org/10.24875/GMM.M22000693.

2. Rubio-Guerra AF, Benítez-Maldonado DR, Lozano-NuevoJJ, Arana-Pazos KC, Huerta-Ramírez S, Narváez-Rivera JL.Correlación entre el grosor de la grasa epicárdica y losmarcadores bioquímicos de riesgo metabólico. Med Clin(Barc) 2018; 151: 236-238. https://doi.org/10.1016/j.medcli.2018.01.019.

3. Rubio-Guerra AF, Guerrero-García C, Meneses-Acero I,Maceda-Serrano A, Benítez-Maldonado DR, Vargas-AyalaG, Narváez-Rivera JL. Epicardial fat thickness, but not intraabdominalfat, correlates with intima-media thicknessin patients with metabolic syndrome: Epicardial fat andintima-media thickness. Obes Res Clin Pract 2019; 13:602-603. https://doi.org/10.1016/j.orcp.2019.10.004.

4. Rubio-Guerra AF, Durán-Salgado MB. Antihypertensivetreatment and vascular extracellular matrix remodeling.Cardiology 2014; 127: 245-246. https://doi.org/10.1159/000357559.

5. Budoff MJ, Alpert B, Chirinos JA, Fernhall B, HamburgN, Kario K, et al. Clinical applications measuring arterialstiffness: an expert consensus for the application of cardioanklevascular index. Am J Hypertens 2022; 35 (5): 441-453.https://doi.org/10.1093/ajh/hpab178.

6. Para I. Albu A. Porojan M.D. Adipokines and arterialstiffness in obesity. Medicina 2021; 57: 653. https://doi.org/10.3390/medicina57070653.

7. Davies JM, Bailey MA, Griffin KJ, Scott DJ. Pulse wavevelocity and the non-invasive methods used to assessit: Complior, SphygmoCor, Arteriograph and Vicorder.Vascular 2012; 20: 342-349. https://doi.org/10.1258/vasc.2011.ra0054.

8. Alberti KG, Eckel RH, Grundy SM, et al. International DiabetesFederation Task Force on Epidemiology and Prevention;National Heart, Lung, and Blood Institute; AmericanHeart Association; World Heart Federation; InternationalAtherosclerosis Society; International Association for theStudy of Obesity. Harmonizing the metabolic syndrome:a joint interim statement of the International DiabetesFederation Task Force on Epidemiology and Prevention;National Heart, Lung, and Blood Institute; American HeartAssociation; World Heart Federation; International AtherosclerosisSociety; and International Association for theStudy of Obesity. Circulation 2009; 120: 1640-1645. doi:https://doi.org/10.1161/CIRCULATIONAHA.109.192644.

9. Mancia G, Kreutz R, Brunström M, Burnier M, Grassi G,Januszewicz A, form the Authors/Task Force Members:2023 ESH Guidelines for the management of arterialhypertension. The Task Force for the management ofarterial hypertension of the European Society of HypertensionEndorsed by the European Renal Association(ERA) and the International Society of Hypertension(ISH). J Hypertens 2023. https://doi.org/10.1097/HJH.0000000000003480.

10. Homsi R, Thomas D, Gieseke J, Meier-Schroers M, Dabir D,Kuetting D, et al. Epicardial fat volume and aortic stiffnessin healthy individuals: A quantitative cardiac magneticresonance study. Rofo 2016; 188 (9): 853-8. https://doi.org/10.1055/s-0042-110098.

11. Cabrera-Rego JO, Iacobellis G, Castillo-Herrera JA, Valiente-Mustelier J, Gandarilla-Sarmientos JC, Marín-Juliá SM, etal. Epicardial fat thickness correlates with carotid intimamediathickness, arterial stiffness, and cardiac geometryin children and adolescents. Pediatr Cardiol 2014; 35 (3):450-6. https://doi.org/10.1007/s00246-013-0799-9.