2024, Number 02
Variations of E. coli to E. coli BLEE in urine cultures and their resistances
Full text
Language: Spanish
References: 9
Page: 121-126
PDF size: 210.89 Kb.
ABSTRACT
Objective: To analyze the behavior of urine cultures from outpatients and hospitalized patients in the clinical laboratory to obtain the incidence and prevalence of extendedspectrum beta-lactamase E. coli and its antimicrobial resistance.Materials and Methods: Retrospective study based on the collection of urine cultures positive for E. coli strain from the clinical laboratory of samples processed between August 2022 and January 2023. Study variables were: age, hospital status (inpatient or outpatient) and prevalence of extended beta-lactamase phenotype.
Results: Three hundred seventy-two E. coli-positive urine cultures from patients with a mean age of 60.3 years were analyzed; 274 had a positive result for the extended spectrum beta-lactamase phenotype (E. coli BLEE), corresponding to 73.6% of the urine cultures in which the strain was identified; 68.13% of patients were seen in the outpatient clinic (none were admitted to the hospital), so the sample was processed only by the clinical laboratory, without intervention in the sample collection.
Conclusions: E. coli with extended-spectrum beta-lactamase phenotype was predominant, suggesting that its incidence is increasing, especially in outpatients. The request of a urine culture, together with the antibiogram, should be part of the initial process aimed at the specific identification of the microorganism, the sensitivity and antimicrobial resistance of the available drugs.
REFERENCES
Tamma PD, Aitken SL, Bonomo RA, Mathers AJ, vanDuin D, Clancy CJ. Infectious diseases society of America2022 guidance on the treatment of extended-spectrumβ-lactamase producing enterobacterales (ESBL-E),carbapenem-resistant enterobacterales (CRE), and Pseudomonasaeruginosa with difficult-to-treat resistance(DTR-P. aeruginosa). Clin Infect Dis 2022; 75 (2): 187-212.doi: 10.1093/cid/ciac268.
Jiménez- Guerra G, Heras-Cañas V, Béjar-Molina LC, Solórzano-Puerto A, et al. Escherichia coli y Klebsiella pneumaniaeproductores de betalactamasa de espectro extendidoen infecciones de vías urinarias: evolución de la resistenciaantibiótica y opciones terapéuticas. Med Clin (Barc) 2017.http://dx.doi.org/10.1016/j.medcli.2017.07.023.