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Colegio de Medicina Interna de México.

2024, Number 04

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Med Int Mex 2024; 40 (04)

Pharmacodermias: How many and which ones?

Villeda AMÁ, Rafael PMG, Minutti PA, Lazcano PBR, Sevilla SMO

Language: Spanish
References: 15
Page: 258-263
PDF size: 385.17 Kb.


ABSTRACT

Objectives: To determine the frequency of pharmacodermias in the Hospital Ángeles Metropolitano, Mexico City, as well as to examine the clinical characteristics and etiological agents.
Materials and Methods: An observational, descriptive, cross-sectional and retrospective study was carried out from March 2022 to June 2023. Patients hospitalized at the Hospital Ángeles Metropolitano, Mexico City, over 18 years of age, with a diagnosis of mucocutaneous adverse drug reactions were included.
Results: Of the 16,651 hospitalized patients in the period of study, 104 were selected for diagnosis of mucocutaneous adverse drug reaction. The prevalence was of 6.24/1000 hospitalized patients, with a predominance of female sex (62.5%). The most frequent pharmacodermia was maculopapular exanthema, followed by urticaria with or without angioedema. Serious adverse drug reactions, such as Stevens-Johnson syndrome, accounted for 1%. The most related drugs were antibiotics, followed by nonsteroidal anti-inflammatory drugs.
Conclusions: The results of this study agree with those reported in the national and international literature; however, epidemiological studies on pharmacodermias in Mexico should be continued in order to establish a more realistic national incidence.


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