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2024, Number 3

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Rev Fac Med UNAM 2024; 67 (3)

Effect of Polystyrene Microplastics on the Cytoskeleton of Human Cells

Pat-Vázquez NI, Tirado-Mendoza R, Cervantes-Uc JM, Leal-Bautista RM, Acosta-González G, Rodríguez-Fuentes N

Language: Spanish
References: 47
Page: 8-21
PDF size: 589.74 Kb.


ABSTRACT

Plastic has become very popular in recent years due to its durability and properties. Despite its many advantages, humanity has developed a certain dependence on this material, which represents an increase in its use and in turn, in waste.
One of the most widely used plastic polymers is the polystyrene (PS), as is used in a wide range of applications due to its low cost and easy production, although after the useful life of the plastic, it is considered as waste. When plastic is exposure to atmospheric conditions such as UV radiation, it degrades and fragments giving rise to microplastics (MPs), which are defined as small particles that do not exceed 5 mm, representing a threat to the environment because when they degrade the properties decay, a dimensional change is generated and they can also be easily transported not only to the environment but also to organisms.
This review article focuses on highlighting the main pathways that MPs follow when interacting with humans and the potential effects of PS-MPs on the cytoskeleton, as well as highlighting the need for more studies in this regard.


REFERENCES

  1. Raja K, Sharma H, Samal B, Bhattacharya J, Ranjan V,Dubey B, et al. Challenges and strategies for effective plasticwaste management during and post COVID-19 pandemic.The Science of the total environment. 2021:750(1):728.https://doi.org/10.1016/j.scitotenv.2020.141514

  2. Prata J. Controlling land-based sources as a measure toreduce (micro)plastic contamination in coastal environments.2018. Frontiers in Marine Science.

  3. Hale R, Seeley M, La Guardia M, Mai L, Zeng E. A GlobalPerspective on Microplastics. JGR Oceans. 2020:125 (1):1-40. https://doi.org/10.1029/2018JC014719

  4. Hwang J, Choi D, Han S, Yong S, Choi J, Hong J. Potentialtoxicity of polystyrene microplastics particles. ScientificReports. 2020:10(1):1-12. https://doi.org/10.1038/s41598-020-64464-9

  5. Rist S, Carney Almroth B, Hartmann N, Karlsson T. Acritical perspective on early communications concerninghuman health aspects of microplastics. The Science of thetotal environment. 2018:626(2018):720-726. https://doi.org/10.1016/j.scitotenv.2018.01.092

  6. Blackburn K, Green D. The potential effects of microplasticson human health: What is known and what is unknown.Ambio. 2021:51(3):518-530. https://doi.org/10.1007/s13280-021-01589-9

  7. Brachner A, Fragouli D, Duarte L, Farias P, Dembski S,Ghosh M, Barisic I, Zdzieblo D, Vanoirbeek J, SchwablP, Neuhaus W. Assessment of Human Health Risks Posedby Nano-and Microplastics Is Currently Not Feasible.International Journal of Environmental Research andPublic Health. 2020:17(23):8832. https://doi.org/10.3390/ijerph172388322020

  8. Pironti C, Ricciardi M, Motta O, Miele Y, Proto A, MontanoL. Microplastics in the Environment: Intake throughthe Food Web, Human Exposure and Toxicological Effects.Toxics. 2021:9(224):1-29. https://doi.org/10.3390/toxics9090224

  9. Moujaber O, Stochaj U. The Cytoskeleton as Regulatorof Cell Signaling Pathways. Trends in BiochemicalSciences. 2020:45(2):96-107. https://doi.org/10.1016/j.tibs.2019.11.003

  10. Kinga K. et al. Polystyrene nanoparticles: Sources, occurrencein the environment, distribution in tissues, accumulationand toxicity to various organisms. EnvironmentalPollution. 2020:262(114297): https://doi.org/10.1016/j.envpol.2020.114297

  11. Nutsch W. La tecnología de la madera y del mueble. 1ered. España. REVERTÉ. 2005:(1)536.

  12. Amato-Lourenço, L, Dos Santos L, de Weger L, HiemstraP, Vijver M, Mauad T. An emerging class of air pollutants:Potential effects of microplastics to respiratory humanhealth? Science of the Total Environment. 2020:749(1):2-7.https://doi.org/10.1016/j.scitotenv.2020.141676.

  13. Ho B, Roberts T, Lucas S. An overview on biodegradationof polystyrene and modified polystyrene: the microbial approach.Critical reviews in biotechnology. 2017:38(2):1-12.https://doi.org/10.1080/07388551.2017.1355293.

  14. Hohmann T, Dehghani F. The Cytoskeleton. A ComplexInteracting Meshwork. Cells. 2019:362(8):1-55. https://doi.org/10.3390/cells8040362.

  15. Frieden, B.R. & Gatenby R. A. Signal transmission throughelements of the cytoskeleton form an optimized informationnetwork in eukaryotic cells. Scientific Reports. 2019:6110.https://doi.org/10.1038/s41598-019-42343-2

  16. Jiang X, Qin Y, Kun L, Zhou Y. The Significant Role of theMicrofilament System in Tumors. Sec. Molecular and CellularOncology. 2021:11(2021). https://doi.org/10.3389/fonc.2021.620390

  17. Duan, L, Chen H, Gao J. The Cytoskeleton of the System.EnPress Journals. 2018:1(1):17-22. [consultado 15 diciembre2023]. Disponible en: https://systems.enpress-publisher.com/index.php/LCBT/article/viewFile/331/239.

  18. Randell SH, Dang H, Broers JLV. The Use of Keratinsas Lung Cell Differentiation Markers and as a DiagnosticTool in Lung Cancer. In Encyclopedia of Respiratory Medicine,Second Edition Elsevier. 2022:(1):694-70: https://doi.org/10.1016/B978-0-08-102723-3.00194-3

  19. Tan Y, Dai J, Wu X, Zhang J. Characteristics, occurrence andfate of non-point source microplastic pollution in aquatic environments.Journal of Cleaner Production. 2022:20(341).https://doi.org/10.1016/j.jclepro.2022.130766

  20. Merlin, I. y Kandasubramanian, B. Effect of microplasticsin water and aquatic systems. Environmental Scienceand Pollution Researc. 2021:28:19544-19562. https://doi.org/10.1007/s11356-021-13184-2

  21. Lu L, Luo T, Zhao Y, Fu Z, Jin Y, et al. Interaction betweenmicroplastics and microorganism as well as gut microbiota:A consideration on environmental animal and humanhealth. Science of the Total Environment. 2019:667:94-100. https://doi.org/10.1016/j.scitotenv.2018.08.353

  22. Ding J, Zhang S, Razanajatovo R, Zou H, Zhu W. Accumulation,tissue distribution, and biochemical effectsof polystyrene microplastics in the freshwater fish red tilapia(Oreochromis niloticus). Environmental Pollution.2018:238:1-9. https://doi.org/10.1016/j.envpol.2018.03.001

  23. Jin Y, Lu L, Tu W, Luo T, Fu Z. Impacts of polystyrene microplasticson the gut barrier, microbiota and metabolismof mice. Science of the Total Environment. 2019:649:308-317. https://doi.org/10.1016/j.scitotenv.2018.08.353.

  24. Sana S, Dogiparthi L, Gangadhar L, Chakravorty A,Abhishek N. Effects of microplastics and nanoplastics onmarine environment and human health. Environmental scienceand pollution research international. 2020:27:44743-44756. https://doi.org/10.1007/s11356-020-10573-x

  25. De Sá L, Oliveira M, Ribeiro F, Rocha T, Futter M. Studiesof the effects of microplastics on aquatic organisms:What do we know and where should we focus our effortsin the future? Science of the Total Environment.2018:(645):1029-1039. https://doi.org/10.1016/j.scitotenv.2018.07.207

  26. Lambert S, Wagner M. Freshwater Environments. EmergingEnvironmental Contaminants? The Handbook of En-vironmental Chemistry. Springer. Cham, Switzerland. 309p. 2018.

  27. Muhamed P, Damaris B, Thomas S, Thomson K.T. Microplasticsin the edible tissues of shellfishes sold for humanconsumption. Chemosphere. 2021:264(2): https://doi.org/10.1016/j.chemosphere.2020.128554

  28. Afrin S, Rahman M, Hossain N, Uddin K, Malafaia G.Are there plastic particles in my sugar? A pioneering studyon the characterization of microplastics in commercialsugars and risk assessment. Science of The Total Environment.2022:837(155849): https://doi.org/10.1016/j.scitotenv.2022.155849

  29. Yang D, Shi H, Li L, Li J, Jabeen K, Kolandhasamy P.Microplastics Pollution in Table Salts from China. EnvironmentalScience & Technology. 2015:49(22):13622-13627. https://doi.org/10.1021/acs.est.5b03163

  30. Diaz M, Conesa J, Fullana A. Microplastics in Honey,Beer, Milk and Refreshments in Ecuador as EmergingContaminants. Sustainability 2020:12(5514):1-17: https://doi:10.3390/su12145514

  31. Schymanski D, Goldbeck C, Humpf H, Fürst P. Analysisof microplastics in water by micro-Raman spectroscopy:Release of plastic particles from different packaging intomineral water. Water Research. 2018:129:154-162. https://doi.org/10.1016/j.watres.2017.11.011

  32. Wright S, Kelly F. Plastic and Human Health: A Micro Issue?Environmental Science & Technology. 2017:51(12):6634-6647. https://doi.org/10.1021/acs.est.7b00423

  33. Ambriz X, De Lanerolle P, Ambrosio J. The Mechanobiologyof the Actin Cytoskeleton in Stem Cells duringDifferentiation and Interaction with Biomaterials.Stem Cells International. 2018:8(1):1-11. https://doi.org/10.1155/2018/2891957.

  34. Hesler M, Aengenheister L, Ellinger B, Drexel R, StraskrabaS, Jost C, et al. Multi-endpoint toxicological assessmentof polystyrene nano- and microparticles in different biologicalmodels in vitro. Toxicology in Vitro. 2019:61(1):1-15.https://doi.org/10.1016/j.tiv.2019.104610

  35. Stock V, Böhmert L, Lisicki E, Block R, Cara-Carmona J,Pack L, et al. Uptake and effects of orally ingested polystyrenemicroplastic particles in vitro and in vivo. Archives oftoxicology. 2018:93(1):1817-1833. https://doi.org/10.1007/s00204-019-02478-7

  36. Haddadi A, Kessabi K, Boughammoura S, Rhouma M,Mlouka R, Banni M, et al. Exposure to microplastics leadsto a defective ovarian function and change in cytoskeletonprotein expression in rat. Environmental Science andPollution Research. 2022:29(23):34594-34606. https://doi.org/10.1007/s11356-021-18218-3

  37. Wei Y, Zhou Y, Long C, Wu H, Hong Y, Fu Y, et al.Polystyrene microplastics disrupt the blood-testis barrierintegrity through ROS-Mediated imbalance of mTORC1and mTORC2. Environmental pollution. 2021:(1):289-297. https://doi.org/10.1016/j.envpol.2021.117904.

  38. Enyoh C, Shafea L, Verla A, Verla E, Qingyue W, ChowdhuryT, et al. Microplastics Exposure Routes and ToxicityStudies to Ecosystems: An Overview. EnvironmentalAnalysis Health and Toxicology. 2020:35(1):1-10. https://doi.org/10.5620/eaht.e2020004

  39. Jin Y, Lu L, Tu W, Luo T, Fu Z. Impacts of polystyrene microplasticson the gut barrier, microbiota and metabolismof mice. Science of the Total Environment. 2019:649:308-317. https://doi.org/10.1016/j.scitotenv.2018.08.353.

  40. Wang Y, Zhang D, Zhang M, Mu J, Ding G, Mao Z,et al. Effects of ingested polystyrene microplastics onbrine shrimp, Artemia parthenogenetica. Environmentalpollution. 2019:244:715-722. https://doi.org/10.1016/j.envpol.2018.10.024

  41. Oliviero M, Tato T, Schiavo S, Fernández V, Manzo S,Beiras R. Leachates of micronized plastic toys provokeembryotoxic effects upon sea urchin Paracentrotus lividus.Environmental Pollution. 2019:247:706-715. https://doi.org/10.1016/j.envpol.2019.01.098

  42. Wan Z, Wang C, Zhou J, Shen M, Wang X, Fu Z, et al.Effects of polystyrene microplastics on the composition ofthe microbiome and metabolism in larval zebrafish. Chemosphere.2019:217:646-658. https://doi.org/10.1016/j.chemosphere.2018.11.070

  43. Ju H, Zhu D, Qiao M. Effects of polyethylene microplasticson the gut microbial community, reproductionand avoidance behaviors of the soil springtail, Folsomiacandida. Environmental Pollution. 2019:247:890-897.https://doi.org/10.1016/j.envpol.2019.01.097

  44. Pannetier P, Cachot J, Clérandeau C, Faure F, Van ArkelK, De Alencastro L, et al. Toxicity assessment of pollutantssorbed on environmental sample microplastics collectedon beaches: Part I-adverse effects on fish cell line. Ecotoxicologyand Environmental Safety. 2019:248:1088-1097.https://doi.org/10.1016/j.envpol.2018.12.091

  45. Schirinzi G, Pérez-Pomeda I, Sanchís J, Rossini C, FarréM, Barceló D. Cytotoxic effects of commonly used nanomaterialsand microplastics on cerebral and epithelialhuman cells. Environmental research. 2017:159:579 587.https://doi.org/10.1016/j.envres.2017.08.043

  46. Ragusa A, Svelato A, Santacroce C, Catalano P, NotarstefanoV, Carnevali O. Plasticenta: First evidenceof microplastics in human placenta. Environment international.2021:146:1-15. https://doi.org/10.1016/j.envint.2020.106274.

  47. Zhou X, Wang G, An X, Wu J, Fan K, Xu L, et al.Polystyrene microplastics particles: In vivo and in vitroocular surface toxicity assessment. Environmental Pollution.2022:303:15-29. https://doi.org/10.1016/j.envpol.2022.119126.




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