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2024, Number 2

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Dermatología Cosmética, Médica y Quirúrgica 2024; 22 (2)

Cocaine-induced fixed drug eruption: a study of 26 cases

Muñoz EVF, Maldonado DED, Gutiérrez CR

Language: Spanish
References: 27
Page: 157-162
PDF size: 287.47 Kb.


ABSTRACT

Background: fixed drug eruption is a localized type iv hypersensitivity reaction mediated mainly by CD8+ lymphocytes. The most common etiologic agent are drugs, however, non-drug causative agents such as food, vaccines, and recreational drugs have also been reported.
Material and methods: a retrospective, descriptive, cross-sectional and observational study was carried out in which 26 patients with a clinical diagnosis of cocaine-induced fixed drug eruption were included at the Department of Dermatology and Mycology of the Hospital Civil de Culiacán, in Sinaloa, Mexico, from January 1999 to December 2022.
Results: males 69.2% (n = 18) between 20 to 30 years, affecting abdominal wall in 50% (n = 13). In 65.3% (n = 17) one to five lesions were present and hyperchromic macules were observed in 57.6% (n = 15). Short evolution (‹1 month) in 65.3% (n = 17). All cases were confirmed with the clinic and provocation test.
Conclusions: cocaine can be considered among the etiological agents of fixed drug eruption.


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