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Federación Mexicana de Ginecología y Obstetricia, A.C.

2024, Number 06

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Ginecol Obstet Mex 2024; 92 (06)

Microbiota and probiotic patients with endometriosis

Márquez IAA, Macías RD, Villegas MNG, Valbuena GE

Language: Spanish
References: 37
Page: 252-266
PDF size: 254.08 Kb.


ABSTRACT

Objectives: To describe the diversity of the gut-vaginal microbiota in women with endometriosis compared with those without the disease and to assess whether probiotic supplementation reduces pain scales.
Methodology: Study in two parts: the first is a narrative review focusing on the composition of the gut-vaginal microbiota in women with and without endometriosis. The second is a qualitative systematic review of the scientific evidence regarding probiotic supplementation in patients with endometriosis. For the narrative review, the STROBE statement criteria for observational studies were considered. For the systematic reviews, the PRISMA statement was used to know whether the points of these statements were integrated or not, without the intention to undermine the studies for the review, but to determine how closely they adhered to international guidelines.
Results: Differences in strain diversity were found between women with and without endometriosis. Qualitatively, a greater predominance of Firmicutes, Pseudomonas spp, Clostridiales, Prevotella spp, Atopobium spp and Actinobacteria was observed. With regard to probiotics, the one that coincided in both studies with a positive effect on the reduction of pain perception was Lactobacillus gasseri OLL2809, a probiotic lactic acid producing bacterium that stimulates the production of interleukin-12 (IL-12).
Conclusions: The overall composition of the intestinal and vaginal microbiome differs between women with and without endometriosis. Probiotic supplementation, particularly with Lactobacillus gasseri, may reduce symptoms, including pain, that are characteristic of endometriosis.


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