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2024, Number 06

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Med Int Mex 2024; 40 (06)

Early initiation of immunoglobulin in acute inflammatory demyelinating polyradiculoneuropathy associated with SARS-CoV-2

Rosado CRA, Solís PRJ, Rodríguez MSM
Full text How to cite this article

Language: Spanish
References: 4
Page: 395-397
PDF size: 197.88 Kb.


Key words:

COVID-19, SARS-CoV-2, Guillain-Barre syndrome, Immunoglobulin.

ABSTRACT

Background: Due to the COVID-19 pandemic that began in 2019, various neurological manifestations associated with SARS-CoV-2 infection have been reported, among which Guillain-Barre syndrome stands out. Delayed diagnosis as well as late initiation of treatment can cause poor short-term prognosis and loss of function in patients.
Clinical case: A 57-year-old male patient with no history of chronic degenerative diseases, functional for basic and instrumental activities of daily living, vaccinated with an AstraZeneca dose against COVID-19 that initiated symptoms with liquid evacuations, positive SARS-CoV-2 PCR was reported; a few days after his diagnosis patient showed progressive ascending weakness. When Guillain-Barre syndrome was suspected treatment with immunoglobulin was given, obtaining favorable response.
Conclusions: In Mexico 63-75% of patients with COVID-19 start treatment with immunoglobulin, so it is important to consider Guillain-Barre syndrome a differential diagnosis before the acute onset of weakness after a history of infection by SARS-CoV-2, since a delay can lead to late start of treatment with short-term impact on the functionality of patients.


REFERENCES

  1. Radišić V, Ždraljević M, Perić S, et al. Is there a differencebetween GBS triggered by COVID-19 and those of otherorigins? Egypt J Neurol Psychiatry Neurosurg 2022; 58: 54.doi.org/10.1186/s41983-022-00486-6

  2. Shoraka S, Ferreira MLB, Mohebbi SR and Ghaemi A. SARSCoV-2 infection and Guillain-Barré syndrome: A review onpotential pathogenic mechanisms. Front Immunol 2021;12: 674922. doi: 10.3389/fimmu.2021.674922

  3. Galnares-Olalde JA, López-Hernández JC, García-Grimshaw M,Valdés-Ferrer SI, et al. Guillain-Barré syndrome in Mexico: Anupdated review amid the coronavirus disease 2019 era. RevInvest Clin 2022; 74 (3): 121-130. doi: 10.24875/RIC.22000006

  4. Rath J, Zulehner G, Schober B, et al. Real-world treatmentof adult patients with Guillain-Barré syndrome over the lasttwo decades. Sci Rep 2021; 11: 19170. doi.org/10.1038/s41598-021-98501-y




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Med Int Mex. 2024;40