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Revista Mexicana de Trastornos Alimentarios

2024, Number 2

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Revista Mexicana de Trastornos Alimentarios 2024; 14 (2)

Systemic activation of dopamine D2-like receptors decreases food intake in rats

Tejas-Juárez JG, Cruz-Trujillo R, Díaz-Gandarilla JA, Escartín-Pérez RE, Florán-Garduño B

Language: Spanish
References: 31
Page: 209-221
PDF size: 421.32 Kb.


ABSTRACT

Mexico is one of the top five countries in the world in terms of obesity rates. Obesity is a well-established risk factor for various health issues, including cardiovascular diseases, type II Diabetes Mellitus, cancer, reproductive complications, and psychological disturbances. As dopamine regulates eating behavior, it is crucial to investigate how dopaminergic receptors can improve pharmacological interventions against obesity. Thus, this study aimed to examine the effects of pharmacological systemic activation of D2-like dopamine receptors on standard food intake and satiety expression. Male Wistar rats weighing between 220-240 g were administered subcutaneous doses of 0.03, 0.1, or 0.3 mg/kg of quinpirole, a D2-like receptor agonist, at the beginning of the dark phase of the light/dark cycle. Over two hours, we evaluated standard food intake and behavioral satiety sequence (SSC). Our results indicated that doses of 0.03 and 0.1 mg/kg reduced food intake without affecting postprandial satiety expression. However, the dose of 0.3 mg/kg destabilized SSC, preventing the expression of satiety due to a motor effect. Therefore, we suggest that low doses of quinpirole may be a viable treatment option for obesity without affecting postprandial satiety expression.


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