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2024, Number 3

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Rev Nefrol Dial Traspl 2024; 44 (3)

Renal hypercalciuria: ¿Is it different from idiopathic hypercalciuria?

Spivacow FR, Del Valle E, de Brum A, Di Lello N

Language: Spanish
References: 22
Page: 120-126
PDF size: 138.59 Kb.


ABSTRACT

Introduction: Idiopathic hyper calciuria is the leading risk factor in oxalo-calcium stones and a secondary cause of osteoporosis. It occurs in families with a probably polygenic trait, which involves alterations in intestinal, bone, and renal calcium management. Some studies suggest that more than 50% of calcium excretion is genetically determined, most frequently observed in firstdegree relatives. The objective of our study was to evaluate whether there are clinical, biochemical, and densitometric differences between patients with renal hypercalciuria and idiopathic hypercalciuria. Material and methods: 112 hypercalciuric patients were included, half with elevated PTH. Results: Renal hypercalciuric patients, Group I (n = 56) were older (p ‹ 0.001) and heavier (p ‹ 0.05) than patients with idiopathic hypercalciuria Group II (n = 56). A higher level of iPTH (p ‹0.001) and serum crosslap (p ‹0.05) was presented in patients with renal hypercalciuria. No significant differences were found between the groups in the presence of kidney stones and bone density. According to the presence (n = 32) or absence (n = 24) of kidney stones in Group I (renal hypercalciuria), there were also no significant changes. Conclusion: renal hypercalciuria is a variant of idiopathic hypercalciuria, which to date does not show significant differences with the remaining variants of idiopathic hypercalciuria. Prospective studies with longerterm follow-ups, including genetic evaluation, will confirm the existence or absence of these differences.


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