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Revista Mexicana de Trasplantes

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2024, Number 3

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Rev Mex Traspl 2024; 13 (3)

Tertiary hyperparathyroidism and total parathyroidectomy with autotransplantation in arm for calcium management in kidney transplantation protocol

Saavedra-Estrada NA, González-Contreras I, López-Corrales MA
Full text How to cite this article 10.35366/117844

DOI

DOI: 10.35366/117844
URL: https://dx.doi.org/10.35366/117844

Language: Spanish
References: 5
Page: 134-136
PDF size: 252.05 Kb.


Key words:

tertiary hyperparathyroidism, parathyroid hormone, surgery, total parathyroidectomy, hungry bone syndrome.

ABSTRACT

Hyperparathyroidism is a common anomaly in patients with chronic kidney failure, since hypocalcemia stimulates the parathyroid hormone and the metabolism of calcitriol, leading to bone demineralization, muscular and cardiac alterations due to the great importance of this circulating mineral, calcium deficiency causes a hypertrophy of the parathyroid cells, thereby increasing the PTH leading to these consequences. In the postdialysis patient, calcium continues to be reduced, so calcium supplementation is basic for its treatment and calcium control is difficult to achieve in those who present hyperparathyroidism. The standard for controlling the elevation of PTH in these cases is partial parathyroidectomy, however, in this case we present a total resection of the parathyroids with self-implantation of 50 mg of parathyroid tissue reimplanted in muscle, in order to prevent parathyroid insufficiency and adequate control of post-transplant calcium.


REFERENCES

  1. Zhang LX, Zhang B, Liu XY, Wang ZM, Qi P, Zhang TY et al. Advances in the treatment of secondary and tertiary hyperparathyroidism. Front Endocrinol (Lausanne). 2022; 13: 1059828. doi: 10.3389/fendo.2022.1059828.

  2. Wang R, Reed RD, Price G, Abraham P, Lewis M, McMullin JL et al. Treatment of hypercalcemic hyperparathyroidism after kidney transplantation is associated with improved allograft survival. Oncologist. 2024; 29 (4): e467-e474. doi: 10.1093/oncolo/oyad314.

  3. Santamaría I, Cannata JB. Etiopatogenia del hiperparatiroidismo primario, secundario y terciario: implicaciones de los cambios moleculares en el fracaso terapéutico. Nefrología. 2002; 22 (3): 213-218.

  4. González-Cantú A, Romero-Ibarguengoitia ME, Quintanilla-Flores DL, Reza-Albarrán A, Herrera-Hernández M, Pantoja-Millán JP et al. Eficacia a largo plazo de la paratiroidectomía en hiperparatiroidismo secundario y terciario. Rev Med Inst Mex Seguro Soc. 2019; 57 (6): 371-378.

  5. Huimin C, Ying C, Changying X, Xiaoming Z, Yan Z, Qingting W et al. Effects of parathyroidectomy on plasma iPTH and (1-84) PTH levels in patients with Stage 5 chronic kidney disease. Horm Metab Res. 2018; 50 (10): 761-767. doi: 10.1055/a-0723-2807.




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C?MO CITAR (Vancouver)

Rev Mex Traspl. 2024;13