2022, Number 1
Adolescent with tubulointerstitial nephritis syndrome and uveitis. Case report
Language: Spanish
References: 17
Page: 1-11
PDF size: 407.60 Kb.
ABSTRACT
Introduction: tubulointerstitial nephritis syndrome and idiopathic uveitis, although rare, seem to have a higher incidence than reported, more frequently in women.Objective: to present the case of an adolescent with tubulointerstitial nephritis and uveitis syndrome.
Case presentation: 15-year-old female patient diagnosed with tubulointerstitial nephritis and uveitis, by renal biopsy. The initial symptoms were non-specific, caused by a febrile syndrome of four weeks of evolution, blurred vision, hyperemia, and pain in the left eye. Treatment with steroids was imposed with a successful response and no relapses that worsened renal function during follow-up.
Conclusions: tubulointerstitial nephritis and uveitis syndrome is a condition that requires great diagnostic insight on the part of the specialist, since it is not accompanied by specific alterations. This presentation constitutes a contribution to the dissemination and characterization of a disease where an incidence greater than that reported in the specialized literature is suspected.
REFERENCES
Cárdenas-Velázquez F, Serna-Ojeda JC, Recillas-Gispert C. Síndrome de nefritis túbulo-intersticial y uveítis (TINU) en un paciente mexicano. Reporte de un caso y revisión de la literatura. Rev. Mex. Oftalmol. [Internet]. 2012 [citado 10 May 2021];86(2):118-23. Disponible en: https://www.elsevier.es/es-revista-revista-mexicana-oftalmologia-321-pdf-X0187451912454592
Rueda-Rueda T, Sánchez-Vicente JL, Moruno-Rodríguez A, Castilla-Martino M, López-Herrero F, Contreras-Díaz M, et al. Síndrome de nefritis túbulo-intersticial y uveítis (TINU). Tratamiento con inmunosupresorea. Arch Soc Esp Oftalmol [Internet]. 2018 [citado 10 May 2021];93(1):47-51. Disponible en: https://www.sciencedirect.com/science/article/abs/pii/S0365669117300321
Isnardi CA, Vilela A, Kuschner P, Salvo C, Vanzetti C, Zelechower V, et. al. Síndrome de Nefritis Túbulo–Intersticial Agudo asociado a Uveítis. Medicina (B. Aires) [Internet]. 2016 [citado 10 May 2021];76(6):376-78. Disponible en: http://medicinabuenosaires.com/revistas/vol76-16/n6/376-378-Med76-5-6556-Isnardi-A.pdf
Borrego-García E, Ruíz-Sánchez A, García-Castillo L, Vinuesa-García D. Síndrome de Nefritis Tubulointersticial y Uveitis (Síndrome TINU), en el diagnóstico de Fiebre de Origen desconocido. Diálisis y Trasplante [Internet]. 2018 [citado 10 May 2021];39(1):20-2. Disponible en: https://sedyt.org/revistas/2018_39_1/4-sindrome-de-nefritis.pdf
Abed L, Merouani A, Haddad E, Benoit G, Oligny LL, Sartelet H. Presence of autoantibodies against tubular and uveal cells in a patient with tubulointerstitial nephritis and uveitis (TINU) syndrome. Nephrol Dial Transplant [Internet]. 2008 [citado 10 May 2021];23:1452-5. Disponible en: https://academic.oup.com/ndt/article/23/4/1452/1879569?login=true
Rodríguez-González F, Reyes-Rodríguez M, Hernández FF, Medina-Rivero F. Nefritis tubulointersticial y uveítis: 2 casos clínicos de pacientes hermanos y revisión de la literatura [Internet]. 2016 [citado 10 May 2021];27:90-5. Disponible en: https://sociedadcanariadeoftalmologia.com/wp-content/revista/revista-27/27sco20.pdf
Dávila-Terreros PJ, Portugal R, Alberton V, Paz MM, Besso C, Malvar A, et al. Completando el diagnóstico con los ojos del paciente. Síndrome nefritis tubulointersticial con uveítis (TINU). Rev. nefrol. dial. traspl. [Internet]. 2020 [citado 10 May 2021];40(02):146-9. Disponible en: http://www.scielo.org.ar/pdf/nefro/v40n2/2346-8548-nefro-40-02-146.pdf
Okafor LO. Hewins P. Murray PI. DennistonAK. Tubulointerstitial nephritis and uveitis (TINU) syndrome: a systematic review of its epidemiology, demographics and risk factors. Orphanet J Rare Dis. [Internet]. 2017 [citado 10 May 2021];12(128):[aprox. 9 p.]. Disponible en: https://ojrd.biomedcentral.com/articles/10.1186/s13023-017-0677-2
Pinheiro MA, Rocha MB, Oliveira-Neri B, Oliveira-Parahyba I, Moura L, Costa-De Oliveira CM, et al. TINU syndrome: review of the literature and case report. J. Bras. Nefrol. [Internet]. 2016 [citado 10 May 2021];38(1):[aprox. 7 p.]. Disponible en: https://www.scielo.br/j/jbn/a/B5jtw99gy8YZhxpdNLh6DKy/?lang=en
Amaro D, Cerreño E, Steeples LR, Oliveira-Ramos S, Marques-Neve C, Leal I. Tubulointerstitial nephritis and uveitis (TINU) syndrome: a review. Br J Ophthalmol [Internet]. 2020 [citado 10 May 2021];104(6):742-47. Disponible en: https://www.researchgate.net/profile/Ines-Leal/publication/337200946_Tubulointerstitial_nephritis_and_uveitis_TINU_syndrome_A_review/links/5dcc0bc8299bf1a47b363f0c/Tubulointerstitial-nephritis-and-uveitis-TINU-syndrome-A-review.pdf
Kawamata M, Akimoto T , Sugase T , Otani-Takei N, Miki T, Masuda T, et al.Tubulointerstitial Nephritis and Uveitis Syndrome: Are Drugs Offenders or Bystanders? Clin Med Insights Case Rep [Internet]. 2016 [citado 10 May 2021];9:21-4. [citado 10 May 2021]. Disponible en: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4795485/pdf/ccrep-9-2016-021.pdf