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2025, Number 2

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Acta Med 2025; 23 (2)

Cardiac arrest following neuromuscular antagonism with sugammadex

Achar FT, Fortis OLL, Calva RDS, Lara PO, Cruz VJA
Full text How to cite this article 10.35366/119492

DOI

DOI: 10.35366/119492
URL: https://dx.doi.org/10.35366/119492

Language: Spanish
References: 5
Page: 195-197
PDF size: 179.87 Kb.


Key words:

sugammadex, neuromuscular monitoring, neuromuscular antagonism, cardiac arrest, pulseless electrical activity.

ABSTRACT

Sugammadex is a modified γ-cyclodextrin used to reverse neuromuscular blockade, secondary to aminosteroid-type neuromuscular relaxants (mainly rocuronium). Sugammadex is mainly used for residual neuromuscular blockade at the end of the surgical procedure. Its use must be carried out in a controlled manner since it is not exempt from adverse effects, among which are vomiting, xerostomia, tachycardia, dizziness, hypotension, prolongation of the QT interval, third-degree atrioventricular AV block, acute negative pressure pulmonary edema, anaphylaxis, bradycardia, and cardiac arrest. We present the case of a 64-year-old female patient with a personal history of rhythm disturbance who presented with cardiac arrest after the administration of sugammadex. Although sugammadex provides an important alternative for the reversal of neuromuscular blockade, it should be considered as a potential causative agent of cardiac arrest.


REFERENCES

  1. Anzai A, Utino A, Tosello G, Katayama H, Spir IAZ, Tristao LS, Nery MM et al. Sugammadex in awakening from general anesthesia: systematic review and meta-analysis. Rev Assoc Med Bras (1992). 2022; 68 (9): 1130-1153.

  2. Bailey CR. Sugammadex: when should we be giving it? Anaesthesia. 2017; 72 (10): 1170-1175.

  3. Oliveira C, Marques C, Simoes V, Spencer L, Poeira R, Casteleira M. Bradicardia grave e assistolia associadas ao sugamadex: relato de caso [Severe bradycardia and asystole associated with sugammadex: case report]. Braz J Anesthesiol. 2019; 69 (2): 218-221.

  4. Kim YH. Sugammadex: watch out for new side effects. Korean J Anesthesiol. 2016; 69 (5): 427-428.

  5. Duvaldestin P, Plaud B. Sugammadex in anesthesia practice. Expert Opin Pharmacother. 2010; 11 (16): 2759-2771.




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Acta Med. 2025;23