2007, Number 2
<< Back Next >>
Rev Mex Pediatr 2007; 74 (2)
Leukocyte adhesion deficiency type I. A case report and literature review
Quero-Hernández A, Zárate AR, Tenorio RH
Language: Spanish
References: 15
Page: 80-83
PDF size: 133.08 Kb.
ABSTRACT
The leukocyte adhesion deficiency syndrome is a rare entity characterized by granulocytic functional alterations related to its adhesion, chemotaxis and phagocytosis of opsonized microorganisms. The children have chronic infections diseases and slow scaring of wounded by these reason use to be a late detachment of the umbilical cord, absence of pus in the local lesions: in spite of the leukocytosis. Here is presented a case of an three months age infant discussing the findings in regard to the information in cases reported.
REFERENCES
Bunting M, Harris ES, McIntyre TM, Prescott SM, Zimmerman GA. Leukocyte adhesion deficiency syndromes: adhesion and tethering defects involving beta 2 integrinas and selectin ligands. Curr Opin Hematol 2000; 9: 30-5.
Dinauer MC. The phagocyte system and disorders of granulopoiesis and granulocyte function. In: Nathan David G, Orkin Stuart H. Editors. Hematology of Infancy and Childhood. 5th ed. Saunders 1998: 889-967.
Sabatino G, De Martino M, Chiarelli F, Paciocco D, Amerio G. Leucocyte adhesion deficiency disorder in an infant. In J Immunopathol Pharmacol 1999; 12: 139-42.
Boxer LA. Neutrophil disorders: qualitative abnormalities of the neutrophil. In: Beutler E, Marshall A, Lichtman B, Coller S, Kipps TJ. Ed. Hematology. 5th ed. New York: Mc Graw- Hill 1995: 828-44.
Phillips ML, Schwartz BR, Etzioni A, Bayer R, Ochs HD, Paulson JC et al. Neutrophil adhesion in leucocyte adhesion deficiency syndrome type 2. J Clin Invest 1995; 96: 2898-06.
Thomas C, Le Deist F, Cavazzana-Calvo M, Benkerrou M, Haddad E et al. Results of allogenic bone marrow transplantation in patients with leucocyte adhesion deficiency. Blood 1995; 86: 1629-35.
Mancias C, Infante AJ, Kamani NR. Matched unrelated donor bone marrow transplantation in leucocyte adhesion deficiency. Bone Marrow Transplant 1999; 24: 1261-3.
Bauer TR Jr, Hickstein DD. Gene therapy for leucocyte adhesion deficiency. Curr Opin Mol Ther 2000; 2: 383-8.
Hynes RO, Lander A. Contact and adhesive specificities in the associations, migrations, and targeting of cells and axons. Cell 1992; 68: 303-22.
Harris ES, Shigeoka A, Li W, Adams R, Prescott S, McIntyre T et al. A novel syndrome of variant leucocyte adhesion deficiency involving defects in adhesion mediated by B1 and B2 integrins. Blood 2001; 97: 767-76.
Lasky LA. Selectins: Interpreters of cell-specific carbohydrate information during inflammation. Science 1992: 258-64.
Timothy M, Carlos, Harlan JM. Leucocyte-endothelial adhesion molecules. Blood 1994; 84: 2068-101.
Mogica M, López D, Canseco R, Becerril AM. Síndrome de adhesión leucocitaria deficiente: informe de un caso. Rev Alerg Mex 1999; 64: 140-5.
Kuijpers T, van Lier R, Hamman D, Buer M, Thing Y, Weening R et al. Leukocyte adhesion deficiency type I (LAD I) variant. J Clin Invest 1997; 100: 1721-33.
Etzioni A, Alan R. Leukocyte adhesion deficiency III: a group of integrin activation defects in hematopoietic lineage cells. Curr Opin Allergy Clin Immunol 2004; 4: 485-90.