2007, Number 2
Med Crit 2007; 21 (2)
THE role of β-2 microglobulin as a marker of renal failure in obstetric population
Meneses CJ, Briones VCG, Moreno SA, Amezola CMA, Anaya TFJ, Mújica HM, Díaz de LPM, Briones GJC
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Language: Spanish
References: 9
Page: 63-66
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ABSTRACT
Background: Acute renal failure (ARF) is a condition associated to multiple surgical and medical problems during pregnancy and puerperium. During ARF glomerular filtration rates are diminished resulting in elevated levels of β2-microglobulin (β2M), a low molecular weight polypeptide that undergoes glomerular filtration and tubular resorption. Increases in serum levels of this molecule have been previously documented in patients with ARF preceding a fall in glomerular filtration and the arisal of serum creatinine.Objective: To determine the levels of β2M in obstetric patients with severe pre-eclampsia and ARF.
Material and methods: Case series of 20 patients with severe preeclampsia complicated with ARF documented by a creatinine clearance rate ‹ 25 mL/min in the Intensive Care Unit (ICU). β2M was determined by an Enzyme Linked Fluorescent Assay ELFA (BioMeriéux-Mex, VIDAS) with a normal cut-off point between 0.81-2.19 mg/L. Statistical analyses was performed using descriptive and inferential analyses using Student t test, and the results expressed in mean, standard deviation SD accepting a significance for p ‹ 0.05.
Results: Levels of β2M and creatinine clearance are included in table 1. We stratified the results between recovered and deceased patients showed in table 2.
Conclusions: β2M and creatinine clearance rates are useful markers for ARF.
Discussion: There is statistical difference between in the levels of β2M between the deceased and surviving patients suggesting that a systemic inflammatory response is involved in the genesis of ARF in severe pre-ecliptic patients. Further studies are necessary to determine the true value of β2M in this patients.
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