Escandón PS, Figueroa HMF, Uriarte RK, Hernández VM, Berumen GC, Vega MME

Language: Spanish
References: 7
Page: 33-35
PDF size: 149.15 Kb.

ABSTRACT

Nicolau syndrome (NS), also known as embolia cutis medicamentosa, is a rare complication of intramuscular injections characterized by skin necrosis with a livedoid pattern. It is thought to result from perivascular damage caused by trauma during the injection. We present the case of a 76-year-old male who developed an ulcer with fibrin, granulation tissue, and hyperpigmented perilesional skin on the lateral gluteus following a vitamin B12 injection. After receiving appropriate treatment, the lesions fully resolved.

REFERENCES

1. Tabor D, Bertram CG, Williams AJK, Mathers ME y Biswas A,Nicolau syndrome (embolia cutis medicamentosa): a rare andpoorly recognized iatrogenic cause of cutaneous thromboticvasculopathy, Am J Dermatopathol 2018; 40(3):212-5.

2. Dadaci M, Altuntas Z, Ince B, Bilgen F, Tufekci O y Poyraz N,Nicolau syndrome after intramuscular injection of non-steroidalanti-inflammatory drugs (nsaid), Bosn J Basic Med Sci 2015;15(1):57-60.

3. Freudenthal W, Lokales embolisches bismogenol-exanthem, Archivfür Dermatologie und Syphilis 1924; 147(1):155-60.

4. Nicolau P, Dermite livédoïde et gangréneuse de la fesse consécutiveaux injections intramusculaires de la syphilis, Ann VenereolMal Venereol 1925; 20:321.

5. Lardelli PF, Jermini LMM, Milani GP, Peeters GGAM, Ramelli GP,Zgraggen L, Terrani I, Bianchetti MG, Vanoni F, Faré PB y LavaSAG, Nicolau syndrome caused by non-steroidal anti-inflammatorydrugs: systematic literature review, Int J Clin Pract 2020;74(10):e13567.

6. Álvarez AM y Muñoz MA, Síndrome de Nicolau o embolia cutismedicamentosa: a propósito de un caso, Revista de la AsociaciónColombiana de Dermatología y Cirugía Dermatológica2020; 28(3):264-8.

7. Mira MN, Cuadros NV y Ponce EA, Síndrome de Nicolau:afección rara y prevenible, Dermatología Revista Mexicana2024; 68(2):216-9.