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2025, Number 3

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Acta Med 2025; 23 (3)

Intraoperative refractory hypotension in a patient receiving ARB treatment

Achar FT, Prol CA, Cruz VJA, Fortis-Olmedo LL
Full text How to cite this article 10.35366/119960

DOI

DOI: 10.35366/119960
URL: https://dx.doi.org/10.35366/119960

Language: Spanish
References: 5
Page: 287-288
PDF size: 169.75 Kb.


Key words:

arterial hypotension, refractory arterial hypotension, intraoperative arterial hypotension, perioperative ARBs, vasopressors.

ABSTRACT

Angiotensin II receptor antagonists (ARBs) are still considered first-line treatment in patients with systemic arterial hypertension (SAH) due to their inhibition of the renin-angiotensin-aldosterone system (RAAS). Perioperative use of these agents may cause severe refractory hypotension in conjunction with general anesthesia and/or neuraxial anesthesia. We present the case of a 58-year-old female patient who developed severe hypotension refractory to conventional treatments after induction of anesthesia despite the suspension of losartan 24 hours prior to the surgical procedure. Increased awareness of the possibility of severe refractory hypotension from chronic ARB use is required.


REFERENCES

  1. Roshanov PS, Rochwerg B, Patel A, Salehian O, Duceppe E, Belley-Coté EP et al. Withholding versus Continuing angiotensin-converting enzyme inhibitors or Angiotensin II receptor blockers before noncardiac surgery. Anesthesiology. 2017; 126 (1): 16-27.

  2. Saugel B, Kouz K, Hoppe P, Maheshwari K, Scheeren TWL. Predicting hypotension in perioperative and intensive care medicine. Best Pract Res Clin Anaesthesiol. 2019; 33 (2): 189-197.

  3. Fleisher LA, Fleischmann KE, Auerbach AD, Barnason SA, Beckman JA, Bozkurt B et al. 2014 ACC/AHA guideline on perioperative cardiovascular evaluation and management of patients undergoing noncardiac surgery: a report of the American college of cardiology/American heart association task force on practice guidelines. J Am Coll Cardiol. 2014; 64 (22): e77-e137.

  4. Mets B. Management of hypotension associated with angiotensin-axis blockade and general anesthesia administration. J Cardiothorac Vasc Anesth. 2013; 27 (1): 156-167.

  5. Hedman K, Mann C, Spulecki C, Castner J. Lowdose vasopressin and analogues to treat intraoperative refractory hypotension in patients prescribed angiotensinconverting enzyme inhibitors undergoing general anesthesia: a systematic review. AANA J. 2016; 84 (6): 413-419.




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Acta Med. 2025;23