medigraphic.com
Federación Mexicana de Ginecología y Obstetricia, A.C.

2025, Number 5

<< Back Next >>

Ginecol Obstet Mex 2025; 93 (5)

Angiomyofibroblastoma. A rare tumor. Clinicopathological study of four cases

Sarabia OR, García TJP, Amezcua RA

Language: Spanish
References: 15
Page: 167-174
PDF size: 463.52 Kb.


ABSTRACT

Objective: To analyze the clinical and histopathologic characteristics and treatment of patients with angiomyofibroblastoma.
Materials and Methods: Retrospective and descriptive analysis of patients with a histopathologic diagnosis of angiomyofibroblastoma treated at the General Hospital of Albacete between 2006 and 2023. Clinical and histopathologic characteristics, treatment, and follow-up were analyzed.
Results: A total of 1,919 vulvar biopsies and 824 vaginal biopsies were analyzed. Benign lesions accounted for 67.07%, dysplastic lesions for 19.68%, and malignant neoplasms for 13.23% of the specimens. Four cases of patients diagnosed with angiomyofibroblastoma were identified, representing 0.14% of all lesions. The mean age of the patients was 41 years with a range of 31 to 55 years. Treatment was entirely surgical and no recurrences were observed.
Conclusions: Angiomyofibroblastoma is a rare benign soft tissue neoplasm. Differential diagnosis is crucial because its clinical manifestations and histologic features may resemble other vulvar mesenchymal tumors, but with different biological behavior and prognosis.


REFERENCES

  1. Omori M, Toyoda H, Hirai T, Ogino T, et al. Angiomyofibroblastomaof the vulva: a large pedunculated mass formation. Acta Med Okayama 2006; 60 (4): 237-42. https://doi.org/10.18926/AMO/30712

  2. Lee SH, Yang JW, Do JM, Seo DH, et al. Angiomyofibroblastoma-like tumor of the scrotum. Korean J Urol 2010;51 (5): 365-7. https://doi.org/10.4111/kju.2010.51.5.365

  3. Shintaku M, Noda H, Hashimoto H. Large polypoid angiomyofibroblastomaof the vulva: report of a case. Int J ClinExp Pathol 2018; 11 (11): 5509-5513

  4. Wang Y, Zhang Y, Lv B, Feng Y. Large-sized pedunculatedand polypoidal angiomyofibroblastoma of the vulva: A casereport and literature review. J Obstet Gynaecol Res 2018;44 (8): 1492-1497. https://doi.org/10.1111/jog.13692

  5. Haroon S, Irshad L, Zia S, Ali AH, et al. Aggressive angiomyxoma,angiomyofibroblastoma, and cellular angiofibromaof the lower female genital tract: related entities withdifferent outcomes. Cureus. 2022; 14 (9): e29250. https://doi.org/10.7759/cureus.29250

  6. Shilpa G, Sharma S, Parthiban SRR, Khan U. Angiomyofibroblastomaof the vulva. Gynecol Minim Invasive Ther 2022;11 (3): 185-87. https://doi.org/10.4103/GMIT.GMIT_29_20

  7. Chapel DB, Cipriani NA, Bennett JA. Mesenchymal lesions ofthe vulva. Semin Diagn Pathol 2021; 38 (1): 85-98. https://doi.org/10.1053/j.semdp.2020.09.003

  8. Pradhan P, Sahu N, Dash K, Misra P, et al. Angiomyofibroblastomaof the vulva: a rare case report with brief reviewof literature. J Midlife Health 2019; 10 (2): 105-107. https://doi.org/10.4103/jmh.JMH_156_18

  9. Del Carmen MG. Mesenchymal tumors of the female genitaltract: Treatment. Surg Pathol Clin 2009; 2 (4): 835-48.https://doi.org/10.1016/j.path.2009.08.022

  10. Granter SR, Nucci MR, Fletcher CD. Aggressive angiomyxoma:reappraisal of its relationship to angiomyofibroblastomain a series of 16 cases. Histopathology 1997; 30 (1):3-10 https://doi.org/10.1046/j.1365-2559.1997.d01-556.x

  11. Chen L, Sun Q, Zhang J, Xu X, et al. Rare vulvar angiomyofibroblastoma:case series and literature review. Int J WomensHealth 2023; 15: 427-31. https://doi.org/10.2147/IJWH.S40312

  12. Anggraeni TD, Nuranna L, Luthfiyanto M, Siregar NC, et al.Rare case of huge vulvar angiomyofibroblastoma in a youngfemale. Gynecol Oncol Rep 2021; 36: 100751. https://doi.org/10.1016/j.gore.2021.100751

  13. Eckhardt S, Rolston R, Palmer S, Ozel B. Vaginal angiomyofibroblastoma:a case report and review of diagnosticimaging. Case Rep Obstet Gynecol 2018; 2018: 7397121.https://doi.org/10.1155/2018/7397121

  14. Angelico G, Marletta S, Broggi G, Vigneri P, et al. Practicalapproach to the diagnosis of the vulvo-vaginal stromaltumors: an overview. diagnostics (Basel). 2022; 12 (2): 357.https://doi.org/10.3390/diagnostics12020357

  15. Kumar N, Goyal A, Manchanda S, Sharma R, et al. Aggressivepelvic angiomyxoma and its mimics: can imaging bethe guiding light? Br J Radiol 2020; 93 (1111): 20200255.https://doi.org/10.1259/bjr.20200255




2020     |     www.medigraphic.com