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2025, Number 2

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Rev Nefrol Dial Traspl 2025; 45 (2)

Primary glomerulopathies: lima 2006-2015

Gonzáles NRJ, Hurtado AAN, Asato HC, Sumire ÚJ

Language: Spanish
References: 29
Page: 83-90
PDF size: 307.76 Kb.


ABSTRACT

Introduction: Primary glomerulopathies (GPs) constitute a heterogeneous group of renal diseases that mainly affect the glomeruli without identifiable etiologic cause. They present clinically with a broad spectrum of manifestations, from proteinuria, hematuria, and nephrotic syndrome to acute or chronic renal failure. The epidemiology of GP varies geographically; in Peru, focal segmental glomerulosclerosis (FSGS) has increased significantly, becoming the most prevalent form. Materials and Methods: A retrospective study was performed using renal biopsies from a referral center in Lima between 2006 and 2015. Patients older than 18 years with a biopsy-confirmed diagnosis of GP were included. Samples were processed for light microscopy and immunofluorescence, classifying glomerular lesions according to their morphological pattern and type of immune deposits. Results: Of the 1259 GP biopsies, 960 met the inclusion criteria. FSGS was the most frequent form (67%), followed by membranous glomerulopathy (MG) (21%) and glomerulopathy with membranoproliferative pattern (MPG) (7%). The annual rate of GPs was 13.2 patients per million population. Conclusion: The prevalence of FSGS has doubled in the last decade, displacing MPG, suggesting an epidemiological change in the Peruvian population.


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