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2025, Number 1

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Bol Clin Hosp Infant Edo Son 2025; 42 (1)

DRESS Syndrome: A Great Imitator in Pediatric Emergencies

Sotelo BB, Elizalde MN, Ramos GF, Contreras NN
Full text How to cite this article

Language: Spanish
References: 15
Page: 44-49
PDF size: 269.73 Kb.


Key words:

Eosinophilia, Hepatitis, Valproic Acid, Drug Hypersensivity Syndrome, Pediatric Emergency Medicine.

ABSTRACT

DRESS syndrome is a serious adverse skin reaction to drugs as it can lead to multiorgan involvement and death. By sharing clinical and laboratory characteristics with other entities, its diagnosis is difficult, mainly in pediatric emergencies where it can be confused with other typical childhood diseases. This is the clinical case, evolution and therapy used in a 12-year-old patient with DRESS Syndrome with liver disease and which had a favorable evolution, as well as describe the characteristics of this problem and its main differential diagnoses in pediatric age. DRESS Syndrome is considered a dermatological emergency that requires a high index of suspicion for its timely diagnosis.


REFERENCES

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  2. ChoYT, Yang CW, Chu CY. Drug Reaction with Eosinophiliaand Systemic Symptoms (DRESS): An interplayamong drugs, viruses, and immune system.Int J Mol Sci. 2017; 18 (6): 1243.

  3. Gómez-Cerdas MT, Corrales-Morales TM, Ugalde-Jiménez O. Síndrome de DRESS: abordaje diagnósticoy terapéutico. Rev Med Sinerg. 2019; 4(6):60-72.

  4. Sánchez X, Merlano C, Cruz CM. Síndrome de hipersensibilidada medicamentos con eosinofilia ysíntomas sistémicos (DRESS). Rev Asoc ColombDermatol Cir Dermatol. 2019. 16(3): 208-210.

  5. Robinson SK, Jefferson IS, Agidi A. Pediatric DermatologyEmergencies. Cutis. 2020 Mar; 105(3):132-136. PMID: 32352437

  6. Knöpfel N, Noguera L, Latour I. Viral exanthems inchildren: A great imitator. Clin dermatol. 2019; 37(3):213-226.

  7. Fitzpatrick J. Urgencias dermatológicas. Diagnósticosintomático. Elsevier: España; 2018.

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  9. Corneli HM. DRESS Syndrome: Drug Reaction WithEosinophilia and Systemic Symptoms. PediatrEmerg Care. 2017; 33(7): 499-504.

  10. Bluestein SB, Yu R, Stone C. Reporting of drug reactionwith eosinophilia and systemic symptomsfrom 2002 to 2019 in the US Food and Drug AdministrationAdverse Event Reporting System. J AllergyClin Inmmunol. 2021; 9(8): 3208-3211.

  11. Isaacs M, Cardones AR, Rahnama-Moghadam S.DRESS syndrome: clinical myths and pearls. Cutis.2018; 102(5): 322-326.

  12. Silva-Tirado MP. Síndrome DRESS. Med Int Mex.2019; 35(2): 325-331.

  13. Rossi ME, Carbias G, Balseiro V, Villanueva DV, et al.Comparación de diferentes escalas de puntuacióncon base en los criterios diagnósticos del síndromeDRESS y determinación de sus característicasclínicas. Dermatol Rev Mex. 2021; 65(6): 888-898.

  14. Cabañas R, Ramírez E, Sendagorta E, et al. SpanishGuidelines for Diagnosis, Management, Treatment,and Prevention of DRESS Syndrome. J InvestigAllergol ClinImmunol. 2020; 30(4): 229-253.

  15. Calle AM, Aguirre N, Ardila JC, et al. DRESS syndrome:A literature review and treatment algorithm.WAOJ. 2023; 16(3): 100673.




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Bol Clin Hosp Infant Edo Son. 2025;42